Activity of Tigecycline (GAR936) against Acinetobacter baumannii Strains, Including Those Resistant to Imipenem (original) (raw)

The study evaluated the in vitro activity of tigecycline and imipenem against 49 strains of Acinetobacter baumannii, specifically including imipenem-resistant isolates. Findings indicated that tigecycline exhibited good bacteriostatic activity, with a MIC 90 of 2 mg/liter for this pathogen, and showed susceptibility in 92% of the strains tested. Conversely, imipenem showed lower effectiveness with a 20% susceptibility rate among the isolates, highlighting tigecycline's potential as a therapeutic option against multidrug-resistant A. baumannii infections.