One-pot conversion of arylamines, DEC and ethylene oxide to oxazolidinones catalyzed by ionic liquids (original) (raw)

A novel l-amino acid ionic liquid for quick and highly efficient synthesis of oxime derivatives – An environmental benign approach

Arabian Journal of Chemistry, 2011

A mild, efficient, and eco-friendly procedure for the conversion of aliphatic, alicyclic and aromatic carbonyl compounds into the corresponding oximes, was catalyzed by a novel imidazolium based ionic liquid coupled with amino acid (asparagine) (L-AAIL, L-Amino acid functionalized ionic liquid) catalytic system. The quantitative conversion of aryl and alkyl carbonyl compounds into the corresponding oximes was achieved by simply grinding at ambient temperature using 0.05 mmol of catalyst in 50 s. In addition, this L-AAIL catalyst exhibited good reusability for five consecutive trials without significant loss of its catalytic activity.

Green Synthesis of 2-Oxazolidinones by an Efficient and Recyclable CuBr/Ionic Liquid System via CO2, Propargylic Alcohols, and 2-Aminoethanols

Catalysts, 2021

With the aim of profitable conversion of carbon dioxide (CO2) in an efficient, economical and sustainable manner, we developed a CuBr/ionic liquid (1-butyl-3-methylimidazolium acetate) catalytic system which could efficiently catalyze the three-component reactions of propargylic alcohols, 2-aminoethanols, and CO2 to produce 2-oxazolidinones and α-hydroxy ketones. Remarkably, this catalytic system employed lower metal loading (0.0125-0.5 mol%) but exhibited the highest turnover number (2960) ever reported, demonstrating its excellent activity and sustainability. Moreover, our catalytic system could efficiently work under 1 atm of CO2 pressure and recycle among the metal-catalyzed systems.

Synthesis of Oxacyclic Derivatives Using Ionic Liquids as a Reaction Medium

Current Organic Synthesis, 2012

This review presents the recent applications of RTILs (Room Temperature Ionic Liquids) as reaction media in the main oxacyclic synthesis. Advantages and disadvantages of this green reaction media are described throughout the manuscript. Specifically allusion is made to the rates, mild conditions, co-catalyst, toxicity as well as the possibility of RTIL recycle, compared to the classical volatile organic compounds (VOCs). By showing all the information collected from the literature about this topic, we also expect to motivate the wide scientific community involved in the field of organic synthesis, to use RTILs as environmental friendly solvents and encourage the research on green chemistry.

Basic ionic liquid [BMIM][OH] as heterogeneous catalyst mediated solvent-free Stobbe condensation applying grindstone technique for the synthesis of novel β-arylidene-β-benzoylpropionic acid derivatives

Journal of the Chinese Advanced Materials Society, 2017

The basic ionic liquid 1-butyl-3-methylimidazolium hydroxide, i.e. [BMIM][OH], proficiently catalyzed Stobbe condensation in solventfree condition. An extensive range of aromatic aldehydes simply undergo condensations with methyl-b-benzoyl propionate. The reactions proceed at room temperature and are very fast (10 min). However, the most crucial feature of this methodology is the solvent-free approach and applying grindstone technique for condensation, which is generally not possible by any other conventional reagents and was not addressed adequately in literature providing a general and convenient procedure. The potential application of [BMIM][OH] in organic synthesis is increasing rapidly due to its high yields of the desired products (80%-92%), minimal reaction time, reaction simplicity, and low-cost chemicals. All novel compounds of b-arylidene-b-benzoylpropionic acid derivatives were characterized by IR, 1 H NMR, and mass spectra.

Ionic Liquids : A New Trend in Drug Synthesis Using Green Chemistry

Environmental pollution is majorly caused by the chemical and pharmaceutical industries which have increased multifold time in the last several decades. It is the responsibility of science to design the process which will generate the less hazardous chemicals and much environmentally friendly waste. Ionic liquid finds a source of hope in reducing the organic solvent waste in coming years. These Ionic liquids may replace the organic solvents which are hazardous, toxic and non-environmentally friendly used in the synthesis of chemical compounds. This review article describes the Introduction to Ionic liquids, their types and classification, the advantages of their use in replacement of organic solvent in the synthesis of chemicals compounds and drug substances.

Applications of ionic liquids in organic synthesis and catalysis

Clean Technologies and Environmental Policy, 2013

In recent years, various novel and greener methodologies have been developed using ionic liquids (ILs). In these reactions, IL has played multiple roles like catalyst, solvent, and catalyst support. In some cases, it was observed that IL enables efficient catalytic reactions in comparison with conventional molecular solvents. On the other hand, although a number of catalytic reaction processes in which ILs are used have been established in industry, there were also some unexpected problems, such as unintelligible aberrance or degradation of so-called taskspecific ILs occurring in reaction processes and on the pilot plant scale. Also, several urgent questions regarding the fundamental aspects of ILs particularly toxicity and greener preparation methods need to be clarified. Several industrial applications of ILs are also discussed.