Brazilian Consensus for the Diagnosis, Treatment and Prognosis of Cutaneous Mast Cell Tumors in Dogs (original) (raw)
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Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors
Cells, 2022
Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed.
Mast cell tumor in dogs--incidence and histopathological characterization
2009
Incidence of mast cell tumors, their distribution according to sex, breed, age and localisation in Croatia is not established yet. Also, the statistical significance of the various histopathological parameters according to Patnaik's scheme, in the diagnostics of the tumor grade was not performed. Investigation analysed mast cell tumors histopathologicaly characterized at the Department of General Pathology and Pathological Morphology of the Veterinary Faculty Zagreb from January 1st 2002 to December 31st 2006. Sex, age, breed, localisation and tumor grade of each animal with tumor was recorded and statisticaly evaluated. Each histopathological variable was scored and compared with tumor grade. In the analyzed period, totally 1630 tumors were recorded, and mast cell tumors were found in 106 animals or in 6.5% of all cases. With statistically significant difference, this tumor was found in more cases in male dogs, and average age was 6.96 years. Boxers and retrievers were most fre...
International Journal of Advanced Biochemistry Research, 2023
This study at PGIVER, Jaipur, investigated canine mast cell tumors, prevalent in veterinary oncology, comprising 20% of cutaneous tumors. Employing FNAC and impression smears for cytological diagnosis, 58 samples from diverse breeds revealed a 6.90% incidence. Mast cell tumors exhibited an irregular morphology and firm consistency. Cytologically, smears showed heightened cellularity with round neoplastic cells, anisocytosis, and metachromatic granules. Histopathologically, pleomorphic mast cells with metachromatic granules were observed. The study highlights the correlation between cytology and histopathology, suggesting routine cytological use for neoplastic disease diagnosis.
Ancillary techniques on the evaluation of canine cutaneous mast cell tumors from Brazil
Ciência Rural, 2016
ABSTRACT: The use of histologic classification by a 2-tier grading system only, immunohistochemistry (IHC) for KIT and Ki-67 and polymerase chain reaction (PCR) for internal tandem duplications (ITD) on exon 11 has improved the prognostication of canine cutaneous mast cell tumors (CCMTs) particularly in the United States. However, these techniques are not commonly used in most Brazilian laboratories. Likewise, no studies, to date, have investigated the occurrence of ITD in CCMTs from the country. Thus, this study tested the 2-tier grading system, the immunohistochemistry for KIT and Ki-67 and the PCR for exon 11 in a group of Brazilian CCMTs with the goal of investigating the applicability of these tests in a Brazilian laboratory. Of the 39 CCMTs, 69.2% (27/39) were identified as low-grade and 30.8% (12/39) as high-grade by a 2-tier grading system. All tumors had a KIT expression pattern II, and 30.6% (11/36) had a high growth fraction (Ki-67). PCR amplification was successful in fo...
Epidemiology of Canine Mast Cell Tumors in Uruguay
Brazilian Journal of Veterinary Pathology
We examined in the present study main epidemiological features of canine mast cell tumors in Uruguay, principal breeds of occurrence, age, gender, anatomical distributions, and associated differences of pathological grading. During a three-year period, eighty four out of 405 skin specimens of dogs mainly received at the Veterinary Faculty of Montevideo from private clinics were mast cell tumors. Mix-breed dogs were mostly affected, followed by Labrador Retrievers, Boxers, Pit bulls and Golden Retrievers. Age of patients ranged from 3 to 15 years (median 7.9), and the incidence in females was slightly higher than in males. Tumors were more frequent in the trunk, followed by extremities, scrotum and neck. The majority of specimens were of high malignancy.
Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade
Polish Journal of Veterinary Sciences, 2017
The aim of the study was to identify significant relationships between the tumour malignancy grade and dogs' age, breed, sex, size, and location of mast cell tumours (MCTs). MCTs accounted for 13.27% of all diagnosed canine skin tumours. The highest incidence was recorded among Boxers, Labrador Retrievers, American Staffordshire Terriers, and Golden Retrievers. Statistical analysis revealed significantly higher probability of occurrence of the grade I mast cell tumour in the French Bulldog in the head, neck, torso, and limb regions, the grade-II mast cell tumour in Boxer, Doberman, Dachshund, shepherds, and setters in the scrotal region, and the grade III mast cell tumour in Shar-Pei in the axilla region. In the group of the oldest dogs aged 11-16, there was higher risk of development of MCTs grade II and III. Young dogs (aged 2-3 and 4-6) were found to be more prone to development of MCTs grade I. There was no correlation between MCTs grade and dogs' sex and size. To the authors' knowledge this is the first report on statistical relationships between the degree of mast cell tumour malignancy and dogs' phenotypic traits, age and tumour location. This analysis indicate predilections for development of the particular mast cell tumour malignancy degrees in certain dog breeds, age, and anatomical location.
Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal
Frontiers in Veterinary Science, 2021
Mast cell neoplasms are one of the most frequently diagnosed malignancies in dogs. The clinical picture, course, and prognosis vary substantially among patients, depending on the anatomic site, grade and stage of the disease. The most frequently involved organ is the skin, followed by hematopoietic organs (lymph nodes, spleen, liver, and bone marrow) and mucosal sites of the oral cavity and the gastrointestinal tract. In cutaneous mast cell tumors, several grading and staging systems have been introduced. However, no comprehensive classification and no widely accepted diagnostic criteria have been proposed to date. To address these open issues and points we organized a Working Conference on canine mast cell neoplasms in Vienna in 2019. The outcomes of this meeting are summarized in this article. The proposed classification includes cutaneous mast cell tumors and their sub-variants defined by grading-and staging results, mucosal mast cell tumors, extracutaneous/extramucosal mast cell tumors without skin involvement, and mast cell leukemia (MCL). For each of these entities, diagnostic criteria are proposed. Moreover, we have refined grading and staging criteria for mast cell Willmann et al. Consensus Classification of Canine Mastocytomas neoplasms in dogs based on consensus discussion. The criteria and classification proposed in this article should greatly facilitate diagnostic evaluation and prognostication in dogs with mast cell neoplasms and should thereby support management of these patients in daily practice and the conduct of clinical trials.
Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006)
Journal of the American Veterinary Medical Association, 2010
SMALL ANIMALS M ast cell tumors are the most common malignant skin cancer in dogs. There is substantial variability in the biological behavior of MCTs in dogs, 1 and a histologic grading scheme developed for classification of MCTs affecting haired skin is one of the strongest prognostic indicators in affected dogs. 2 However, histologic assessment is prone to operator subjectivity, with variable grading results when the same tumor is examined by different pathologists. 3,4 Thus, many other prognostic factors, including various proliferative indices, DNA aneuploidy, c-kit staining pattern, microvessel density, and mitotic index, have been evaluated in an attempt to better predict the biological behavior of MCTs in dogs. 5-26 All of these factors have been studied primarily in MCTs involving haired skin, and none have been validated for tumors arising in other anatomic locations.
Visceral Mast Cell Tumor and Mastocythemia in a Dog
Mast cell tumor manifests as a localized proliferation of mast cells in the skin, or less frequently as a systemic disorder, which may be accompanied by the presence of neoplastic mast cells in the peripheral blood (mastocythemia). In some cases, the neoplastic circulating mast cells originate in the bone marrow, designated as mast cell leukemia, rarely observed in dogs, or the cells may arise from visceral mast cell tumors, characterizing systemic mastocytosis. The aim of this report was to describe a case of a six-year-old female German shepherd dog presenting with history of anorexia, hematemesis and diarrhea. The blood work revealed intense mastocythemia (43%), with degranulated mast cells, and anisocytosis. At necropsy, white nodular lesions in the thymic region and an infiltrative mass in mesenteric and abdominal lymph nodes were observed. Those lymph nodes were enlarged and off-white. Histopathological examination revealed neoplastic mast cells in the liver, spleen, lymph nodes, kidneys, lungs, gastric and enteric mucosae, and adrenal glands. The clinical, hematological and histopathological findings were compatible with mastocythemia, associated with a moderately differentiated visceral mast cell tumor.
European consensus document on mast cell tumours in dogs and cats
Veterinary and Comparative Oncology, 2012
Mast cell tumours (MCT) are commonly encountered in small animal practice. This review outlines the biology of mast cell disease, the physiological consequences of MCT and offers a 'best practice' approach to clinical management of dogs and cats with mast cell disease. Diagnostic tests, conventional management and novel treatments are discussed, and evidence-based recommendations are given.