Mucoepidermoid Carcinoma of the Head and Neck : Clinico-Pathologic Study of 12 Cases (original) (raw)
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Mucoepidermoid carcinoma of the head and neck: A 13-year review
European Journal of Plastic Surgery, 2008
Mucoepidermoid carcinoma (MEC) is a malignant tumour arising from salivary gland tissue. The aim of this study was to review the management of MEC at one institution over a period of 13 years and to identify factors associated with morbidity and mortality. The case notes of patients with MEC treated between 1987 and 2000 were reviewed. Well-differentiated tumours were graded as low grade tumours and poorly differentiated tumours as high grade. Staging was done according to the TMN classification of the American Joint Committee on Cancer (AJCC).The collected data were analysed using GraphPad Prism 4.03. The Kaplan-Meier method and the Logrank Test were used to assess the statistical significance of various groups. There were 37 patients identified. Twenty-one cases were low grade tumours and sixteen high grade. The overall survival rate at 5 and 10 years was 74.8 and 65.2%, respectively. The overall loco-regional control rates at 5 and 10 years were 87.3 and 60.4%, respectively. High grade, high stage and incomplete resection margins had an adverse effect on survival. MEC is best managed in tertiary centres where the patients can be assessed and treated by a multidisciplinary team.
Mucoepidermoid carcinoma of the salivary glands––clinical review of 42 cases
Oral Oncology, 2005
In this retrospective study we analyzed our experience with mucoepidermoid carcinoma (MEC) of the salivary glands and compared our results with those reported in the literature. A total of 42 patients were treated between January 1983 and December 2002 at the Department of Oral and Maxillofacial Surgery, Hanover Medical School. Thirty-three tumors were classified as low grade carcinomas, 9 tumors as high grade carcinomas. Tumor sites were the parotid gland in 11 cases, sublingual and submandibular gland in 6 cases, oral cavity and oropharynx in 22 cases and nasal cavity and maxillary sinus in 3 cases. There were 23 T1-, 6 T2-, 5 T3-and 8 T4-tumors with 35 N0-, 5 N1-and 2 N2-necks, all M0 at presentation. Resection remained incomplete for 9 patients. Six patients received postoperative radiation. Overall survival rates, overall local control rates and overall regional control rates at 5 and 10 years were 79.1% and 65.5%, 89.1% and 80.8%, 92.3% and 87.7%. None of our patients developed distant failure. Grade, stage and margin status significantly influenced prognosis. MEC is a rare tumor entity and should be treated in specialist centres within randomised prospective multicentric trials.
Mucoepidermoid carcinoma of the head and neck in children
International Journal of Pediatric Otorhinolaryngology, 2019
Introduction: Mucoepidermoid carcinoma is a rare malignant salivary gland neoplasm in the pediatric population. Few studies have discussed best practice with respect to diagnosis and treatment in children. Objective: To present our institution's experience with the evaluation and management of pediatric mucoepidermoid carcinoma of the head and neck. Methods: Retrospective chart review of patients under 20 years of age diagnosed with mucoepidermoid carcinoma of the head and neck between 1998 and 2017. Data assessed includes demographics, clinical presentation, imaging examinations, histopathology, treatment, complications, local recurrence, distant metastasis, and follow-up. Results: Sixteen patients (10 female, 6 male) were identified with a median age of 12.9 (IQR: 10.9-15.0) years. Tumors were located within the parotid gland (n = 11, 68.8%), accessory lobe of the parotid gland (n = 2, 12.5%), palate (n = 2, 12.5%), and submandibular region (n = 1, 6.3%). In 9 patients (56.3%) a neoplastic etiology was suspected based on the clinical and/or radiographic findings and confirmed pathologically on biopsy or excision. All patients were treated surgically and five patients required adjuvant radiotherapy. One patient had recurrence requiring re-excision. Seven patients (43.8%) had transient facial paresis post-operatively and one had Frey syndrome. Median follow-up time was 59.7 months (IQR: 18.9-99.3). Conclusion: The malignant nature of mucoepidermoid carcinoma requires comprehensive, multidisciplinary management. Imaging and tissue sampling by fine needle aspiration give clinicians the best insight into location and nature of the mass. Complete surgical excision with attention to preservation of facial nerve and achieving negative margins is desired.
Mucoepidermoid carcinoma: A retrospective clinicopathologic study of 25 cases
Journal of Oral and Maxillofacial Pathology
Tumors of the salivary glands constitute an important area in the field of oral and maxillofacial pathology. [1] Salivary gland tumors are reported to represent between 1% and 5% of all head-and-neck tumors and are either benign or malignant tumors. [2,3] Mucoepidermoid was first described by Masso and Berger in 1924; previously, it was termed as "mucoepidermoid tumor" and was considered to be benign lesion. The World Health Organization (WHO) in 1990 classified it as malignant neoplasm and renamed it as mucoepidermoid carcinoma (MEC). [1,4] Among malignant salivary gland tumors, MEC is the most frequent tumor. Background: Salivary gland tumors are rare and clinically represent a diverse group of neoplasms among which mucoepidermoid carcinoma (MEC) is a relatively common salivary gland tumor with varying potential for aggressive behavior. The purpose of the study was aimed at to analyze the relative frequency and correlate with age, sex, anatomical site and histological grade of MEC and compare the findings with epidemiological data from different geographic locations. Materials and Methods: Twenty-five cases diagnosed with MEC during the period June 1985 to June 2004 (19 years) were retrieved from the
Mucoepidermoid Carcinoma of Palate – A Case Report and Review of Literature
Indian Journal of Dental Advancements, 2019
Malignancy of salivary glands is rare and comprises <3% of head and neck cancers. Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland malignancies. MEC mainly occurs in the parotid gland, along with minor salivary glands being the second common site, particularly palate. MEC occurs most frequently between third and sixth decades of life and affects women more often than men, in the ratio of 3:2. The present case report highlights the need for the proper diagnosis and treatment plan in cases of MEC as it can lead to morbidity and mortality.
Journal of Medical Case Reports, 2012
Introduction: Because well-documented cases of mucoepidermoid carcinomas that are of minor salivary gland origin and occur in children and adolescents have rarely been reported, little information regarding their clinical features and biologic behavior is available. This case report represents a retrospective clinical analysis of five minor salivary gland mucoepidermoid carcinomas accessioned from a 35-year period at the Louisiana State University School of Dentistry and combines the data with 15 well-documented cases from the English language literature. Case presentation: The five mucoepidermoid carcinomas in patients from birth to 19 years of age accounted for 1.3% of the accessioned minor salivary gland neoplasms. There were an additional 15 well-documented cases in the literature. Combining the data for the 20 mucoepidermoid carcinomas resulted in a mean age of 13.5 years and a 2.3:1 female-to-male ratio. Collectively, the hard palate, soft palate, and hard palate/soft palate junction accounted for 85% of the cases. Thirty-five percent of the cases presented as a fluctuant submucosal swelling with surface color alterations. The average duration was five months, and bone involvement occurred in seven cases. A histologic grade of low to intermediate predominated (95%). Surgical removal was the treatment in all cases. Thirteen cases had adequate follow-up of three years or more, and recurrence was documented in only one case. There were no cases of death or metastasis in this series. Conclusions: In children and adolescents, mucoepidermoid carcinomas have a female predilection and occur most commonly on the hard or soft palate or both. A fluctuant submucosal lump with a bluish color is a helpful diagnostic clue. The histologic grades of most mucoepidermoid carcinomas in the first and second decades of life are low and, to a lesser degree, intermediate. Complete surgical excision is the treatment of choice and results in a recurrence rate of less than 10%.
Mucoepidermoid Carcinoma: A Demographic and Histopathological Profile
Journal of Islamabad Medical & Dental College, 2020
Background: To find the frequency and clinico-pathological presentation of mucoepidermoid carcinoma (MEC).Materials and Methods:In this study, we included all the malignant salivary gland tumors. Among these the frequency of mucoepidermoid carcinoma was considered. Age, gender, histopathological grading and anatomical site of tumor were included in data analysis.Results:Out of 60 malignant salivary gland tumors reported to the histopathology department, 30 tumors were diagnosed as mucoepidermoid carcinomas. The patient’s age having mucoepidermoid carcinoma ranged from 6 to 88 years, mean age of 44.9±19.2SD. The male patients were 23 in number while female were 7. Out of 30 cases, 73.3% patients had tumor in parotid gland, while13.3% patients in submandibular gland . Other tumors were in palate, retromolar area, and in posterior 1/3rdof tongue (13.3%). According to histopathological grading 26.6% cases of MEC were of high grade, 26.6 % were intermediate grade and 36.6% were low grade...
Journal of Surgical Oncology, 1991
Thirty-nine cases of mucoepidermoid carcinoma of the salivary glands were reviewed for a reappraisal of the influence of the grade of differentiation on the outcome of the disease. The age of the patients ranged between 7 and 84 years. Fifteen patients were females and 24 males. The tumors were located at the parotid gland (n=30), the submaxillary gland (n=1), the soft palate (n=5) and the oral mucosa NOS (n=3). At presentation 4 tumors were intraglandular and 35 extraglandular; three patients had lymph node metastases and one patient lung metastases. The grade of differentiation was assessed using the criteria of Healey et al. Twelve tumors were classified as grade I, 17 as grade II, and 10 as grade III. Follow-up information was obtained with a duration of 5-144 months (mean 44.7 months). Six cases recurred locally and 5 developed metastases. Five years cumulative survival was 100% for grade I, 70.1% for grade II, and 47.2% for grade III. The results point to the usefulness of the assessment of the grade of differentiation as a guide to anticipate the outcome of the disease.
Salivary mucoepidermoid carcinoma revisited
European Archives of Oto-rhino-laryngology, 2014
Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm composed of varying proportions of mucous, epidermoid, intermediate, columnar, and clear cells and often demonstrates prominent cystic growth. MEC is usually subclassified as low, intermediate, or high grade on the basis of its histologic features, including the presence of cystic spaces, cellular differentiation, proportion of mucous cells, growth pattern, type of invasion, and cytologic atypia. Because even low-grade neoplasms may metastasize, the term mucoepidermoid tumor is inappropriate. The 3-level grading approach to tumor classification has found general acceptance among pathologists; differences in biologic behavior can be demonstrated even though clinical stage has become a better prognosticator. However, in the case of MEC, no universal agreement exists regarding which histologic grading criteria are most the useful, and grading has varied. These issues have led to the investigation of more subjective systems. We describe these new schemes, the histologic variants of MEC, and the ancillary methods that allow for further stratification of patients with MEC, especially for patients with grade 2 tumors, which have a variable and unpredictable clinical course.