Melanoma and Pancreatic Carcinoma : From a Clinical Observation to a Brief Review of the Literature (original) (raw)
Isolated Pancreatic Metastasis From Melanoma: A Case Report
Journal of Carcinogenesis & Mutagenesis, 2014
Malignant cutaneous melanomas are skin tumours with a worse prognosis. Presence of metastasis is an indicator of a very aggressive nature of melanoma. Though it can be rarely seen as a primary tumour of the gastrointestinal system, it is among the most frequently observed metastatic tumor of the gastrointestinal system. Since isolated pancreatic metastasis is rarely seen, limited information is available in the literature. In some publications, resection of isolated pancreatic metastasis has been suggestively associated with prolonged life expectancy of the patients. In our manuscript, we will present a very rarely seen case of malignant skin melanoma with isolated pancreatic metastasis.
Association of melanoma with intraepithelial neoplasia of the pancreas in three patients
Experimental and molecular pathology, 2014
Melanoma and pancreatic cancer are two low frequency types of cancer. In this study, three patients who developed both melanoma and intraepithelial neoplasia of the pancreas were tested for CDKN2A mutations and deletions, and investigated for rare germline copy number variations (CNVs). The three patients were negative for CDKN2A point mutations and intragenic deletions. One of these patients carried two large (>300 kb) germline CNVs, both genomic duplications affecting coding sequences that are not copy number variable in the population. A second patient exhibited loss of the entire Y chromosome, an event probably coincidental related to his advanced age (79 years-old). Our data pinpoint that rare germline CNVs harboring genes can contribute to the cancer predisposition of melanoma and intraepithelial neoplasia of the pancreas.
Pancreatic resection for metastatic melanoma
HPB: Official Journal of The International Hepato Pancreato Biliary Association, 2003
The pancreas is an occasional site of metastases from melanoma. It may be the only location of metastatic disease, but more often the melanoma metastasises to other organs as well. Treatment options are somewhat limited, and the role of operative treatment is poorly de®ned.
Journal of gastrointestinal and liver diseases : JGLD, 2010
Solitary involvement of the pancreas in patients with malignant melanoma is rare and the role of surgery in these patients is not defined. We present a patient with prolonged survival following aggressive surgical management for a solitary metastatic lesion within the pancreas. A 69-year-old male presented with a 10-day history of painless jaundice. His past medical history included a wide local excision for a superficial spreading melanoma, and subsequent loco-regional recurrence requiring lymph node dissection. Imaging on presentation showed a solitary mass in the head of the pancreas, with no signs of metastases. The patient underwent a pancreato-duodenectomy. Histology reported a metastatic malignant melanoma with clear excision margins. There was no nodal involvement and he remained disease-free eight years later. The survival of patients seems to be affected by the ability to perform a curative resection, and by a long disease-free interval between the treatment of the initial...
Preliminary Results on Clinicopathological and Immunohistochemical Features of Malignant Melanomas
Acta Medica Marisiensis, 2013
Objective: To perform a retrospective clinico-pathological and immunohistochemical analysis of malignant melanomas. Methods: One-hundred sixty consecutive cases diagnosed in the Department of Pathology of the County Emergency Clinical Hospital of Tîrgu Mureș, Romania, between January 2000 - December 2009, were used. Of these, 47 cases were melanoma metastases that were excluded from the study; this research was focused on the study of 113 primary melanomas (PMs). In 20 cases of PMs (11 cutaneous, 5 choroidal, and 4 melanomas of the anal canal) immunohistochemical stains were performed using the antibodies p53, Ki67, ER (estrogen receptor), CD8 and CD31. Results: Cutaneous PMs prevailed (83%) followed by choroidal (11%), digestive tract (4%) and nasal mucosa PMs (2%). Independent of their location, PMs predominantly affected females (58%) over age 50. Regarding cutaneous cases, lower limbs (49%) were more affected, followed by the head and neck (18%) and the trunk (18%). We noted neg...
Rare Metastases of Malignant Melanoma
Acta medica medianae, 2014
Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 μm thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S-100 antibody and Melan A antibodies. The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S-100 protein (markers of malignant melanoma), as well as mucins: MUC5AC, MUC2 and CDX2 (markers of different types of primary gastric carcinoma).
A single institution 18-years retrospective analysis of malignant melanoma
The Gulf journal of oncology, 2015
Melanoma accounts for about 2% of all cancer-related mortality in western populations. Surgical excision of localized disease is curative in many patients with 80% overall 5-year survival rate. There are many indicators of prognosis of which tumor burden is predicted by primary site with nodal status being the next most important variable. Patients with advanced stage have very high risk of developing distant metastases and should receive systemic therapy. Despite treatment, majority of locally advanced patients develop metastatic disease. A retrospective analysis of cases of malignant melanoma registered over a period of eighteen years, from October 1990 to September 2007 was done. Patient profile, presentation, disease load, treatment protocols and response on or after treatment were analyzed. The median age at diagnosis in men was 48 years and 50 years in women. At presentation, more than half of studied cases (56.5%) presented with nodal metastases at diagnosis while about three...
Multiorgan Resection (Including the Pancreas) for Metastasis of Cutaneous Malignant Melanoma
2000
Context Several studies have demonstrated improved survival after complete resection of hollow viscus gastrointestinal metastases of malignant melanoma. Patients with metastatic disease of intra-abdominal solid organs might also benefit from complete surgical resection. Case report The authors report the case of a 22-year-old female patient with multiorgan abdominal metastases of cutaneous malignant melanoma, including the ovarium, jejunum, stomach and pancreas.
Melanoma Review: Epidemiology, Risk Factors, Diagnosis and Staging
Study Aim: Cutaneous melanoma accounts for approximately 4% of all skin cancers diagnosis each year in the USA but is responsible for 75% of skin cancer deaths. Physicians need to have an up to date knowledge about the epidemiology, risk factors, and clinical features of melanoma in order to make an early diagnosis and provide appropriate management decisions to improve survival in this aggressive malignancy. We will be presenting an extensive, up to date, literature review of cutaneous melanoma including the epidemiology, risk factors, diagnosis and staging. Method: An extensive literature review was performed using the following search engines: Pubmed, Ovid, Miromedex, and Dynamed. We limited our literature search to research papers written in English using the following keywords: cutaneous melanoma, epidemiology of melanoma, risk factors for melanoma, diagnosis of melanoma, clinical classification and staging of melanoma. Results: As a result of our extensive literature review we present an up to date review on the epidemiology, pathogenesis, risk factors, diagnosis, classification and staging of cutaneous melanoma. Conclusion: Physicians need to have an up to date knowledge about the epidemiology, risk factors, and clinical features in order to make an early diagnosis and provide appropriate management decisions in order to improve the survival patients with this aggressive malignancy.