Melanoma and Pancreatic Carcinoma : From a Clinical Observation to a Brief Review of the Literature (original) (raw)
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Isolated Pancreatic Metastasis From Melanoma: A Case Report
Journal of Carcinogenesis & Mutagenesis, 2014
Malignant cutaneous melanomas are skin tumours with a worse prognosis. Presence of metastasis is an indicator of a very aggressive nature of melanoma. Though it can be rarely seen as a primary tumour of the gastrointestinal system, it is among the most frequently observed metastatic tumor of the gastrointestinal system. Since isolated pancreatic metastasis is rarely seen, limited information is available in the literature. In some publications, resection of isolated pancreatic metastasis has been suggestively associated with prolonged life expectancy of the patients. In our manuscript, we will present a very rarely seen case of malignant skin melanoma with isolated pancreatic metastasis.
Association of melanoma with intraepithelial neoplasia of the pancreas in three patients
Experimental and molecular pathology, 2014
Melanoma and pancreatic cancer are two low frequency types of cancer. In this study, three patients who developed both melanoma and intraepithelial neoplasia of the pancreas were tested for CDKN2A mutations and deletions, and investigated for rare germline copy number variations (CNVs). The three patients were negative for CDKN2A point mutations and intragenic deletions. One of these patients carried two large (>300 kb) germline CNVs, both genomic duplications affecting coding sequences that are not copy number variable in the population. A second patient exhibited loss of the entire Y chromosome, an event probably coincidental related to his advanced age (79 years-old). Our data pinpoint that rare germline CNVs harboring genes can contribute to the cancer predisposition of melanoma and intraepithelial neoplasia of the pancreas.
Pancreatic resection for metastatic melanoma
HPB: Official Journal of The International Hepato Pancreato Biliary Association, 2003
The pancreas is an occasional site of metastases from melanoma. It may be the only location of metastatic disease, but more often the melanoma metastasises to other organs as well. Treatment options are somewhat limited, and the role of operative treatment is poorly de®ned.
Journal of gastrointestinal and liver diseases : JGLD, 2010
Solitary involvement of the pancreas in patients with malignant melanoma is rare and the role of surgery in these patients is not defined. We present a patient with prolonged survival following aggressive surgical management for a solitary metastatic lesion within the pancreas. A 69-year-old male presented with a 10-day history of painless jaundice. His past medical history included a wide local excision for a superficial spreading melanoma, and subsequent loco-regional recurrence requiring lymph node dissection. Imaging on presentation showed a solitary mass in the head of the pancreas, with no signs of metastases. The patient underwent a pancreato-duodenectomy. Histology reported a metastatic malignant melanoma with clear excision margins. There was no nodal involvement and he remained disease-free eight years later. The survival of patients seems to be affected by the ability to perform a curative resection, and by a long disease-free interval between the treatment of the initial...
Preliminary Results on Clinicopathological and Immunohistochemical Features of Malignant Melanomas
Acta Medica Marisiensis, 2013
Objective: To perform a retrospective clinico-pathological and immunohistochemical analysis of malignant melanomas. Methods: One-hundred sixty consecutive cases diagnosed in the Department of Pathology of the County Emergency Clinical Hospital of Tîrgu Mureș, Romania, between January 2000 - December 2009, were used. Of these, 47 cases were melanoma metastases that were excluded from the study; this research was focused on the study of 113 primary melanomas (PMs). In 20 cases of PMs (11 cutaneous, 5 choroidal, and 4 melanomas of the anal canal) immunohistochemical stains were performed using the antibodies p53, Ki67, ER (estrogen receptor), CD8 and CD31. Results: Cutaneous PMs prevailed (83%) followed by choroidal (11%), digestive tract (4%) and nasal mucosa PMs (2%). Independent of their location, PMs predominantly affected females (58%) over age 50. Regarding cutaneous cases, lower limbs (49%) were more affected, followed by the head and neck (18%) and the trunk (18%). We noted neg...
Clinical Journal of Gastroenterology, 2019
There is a wide variety of pancreatic neoplasms identified, but the great majority of them are of primary origin. Metastatic disease in the pancreatic parenchyma is quite rare (2-5% of pancreatic malignancies) and most often is quite difficult to differentiate from other primary lesions. Most of the imaging studies fail to give certain discriminating features for metastatic pancreatic neoplasms, contrary to endoscopic ultrasound and tissue sampling, which can provide an accurate diagnosis. In this report, we present a case of a male middle aged man who was admitted to our hospital with painless jaundice and finally was diagnosed with a cutaneous scalp melanoma dispersedly metastasized to the pancreas and upper gastrointestinal tract (stomach and duodenum).
Innovative Publication, 2017
Pancreatic metastasis of malignant melanoma is rarely diagnosed on EUS FNAC while the patient is alive. Primary or secondary pancreatic malignant melanoma are rarely described in the literature. Most of the cases have been reported in the literature by surgical pathology. A 52-year-old male patient presented with 3 episodes of pain in abdomen for last 15 days. Patient had history of blackish discoloration with mass in big toe which was amputated 1 year age. On examination, multiple soft to firm non tender nodules palpable over right shin, right thigh and over right scapula. Patient was admitted for evaluation of pancreatic mass. CT abdomen and thorax showed lobulated heterogenous mass replacing pancreas with encasement of splenic vessels. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) was performed from the mass of the pancreas. A probable cytomorphological diagnosis of malignant melanoma metastatic to pancreas was made. The final diagnosis of malignant melanoma was confirmed by strong positivity of HMB45 and S100 immunocytochemical staining on endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNAC). We report a very unusual case of malignant melanoma metastatic to pancreas diagnosed by EUS-FNAC. Although this is uncommon in the pancreas, malignant melanoma should be considered in the differential diagnosis of metastatic pancreatic masses on cytology.
Pancreatic Resection for Metastatic Melanoma. Case Report and Review of the Literature
Journal of Gastrointestinal Cancer, 2010
Introduction Pancreatic metastasis from several malignancies are increasingly encountered in clinical practice, and the usefulness of surgical resection has been suggested for certain neoplasms. Isolated pancreatic metastasis from malignant melanoma is a rare occurrence, and the role of surgery as an adjunct to systemic therapy for melanoma metastatic to a solitary or multiple sites is still debated. Case Report We report a patient with melanoma of unknown primary site metastatic simultaneously to the lung and pancreas 3 years after axillary lymph node dissection. Distal pancreatectomy with splenectomy and video thoracoscopic assisted resection of pulmonary metastasis were performed. The postoperative course was uneventful, but 6 months after surgery, the patient experienced single pulmonary recurrence. During chemotherapy with different drugs, pulmonary lesion remained stable for 1 year, and no abdominal recurrence occurred. After then, the size of the lesion progressively increased and a second metastasis occurred in the lung. Five months later, brain metastases occurred, and the patients died 24 months after surgery. Sixteen pancreatic resections for metastatic malignant melanoma, reported with adequate clinical details, were also retrieved from the literature. Conclusion In spite of the very limited experience, it appears that surgical resection is only a palliative procedure, because long-term survival is a rare event. However, considering the lack of effective systemic therapy, surgery may be considered as a part of an aggressive multidisciplinary approach in selected cases with malignant melanoma metastatic to single or multiple visceral sites.
Karger Kompass Dermatologie, 2014
Introduction: Primary dermal melanoma (PDM) is a recently described clinical entity accounting for less than 1% of all melanomas. Histologically, it is located in the dermis or subcutaneous tissue, and it shows no connections with the overlying epidermis. The differential diagnosis is principally made along with that of metastatic cutaneous melanoma. Case Report: A 72-year-old Caucasian woman with a history of multiple cancers (metachronous bilateral breast cancer, meningioma, clear cell renal cell carcinoma, uterine fibromatosis and intestinal adenomatous polyposis), came to our attention with a nodular lesion on her back. After removal of the lesion, the histology report indicated malignant PDM or metastatic malignant melanoma. The clinical and instrumental evaluation of the patient did not reveal any other primary tumour, suggesting the primitive nature of the lesion. The absence of an epithelial component argued for a histological diagnosis of PDM. Subsequently, the patient underwent a wide surgical excision with sentinel node biopsy, which was positive for metastatic melanoma. Finally, the mutational status was studied in the main genes that regulate proliferation, apoptosis and cellular senescence. No pathogenetic mutations in CDKN2A, BRAF, NRAS, KRAS, cKIT, TP53 and PTEN genes were observed. This suggests that alternative pathways and low-frequency alterations may be involved. Conclusions: The 193 differential diagnosis between PDM and isolated metastatic melanoma depends on the negativity of imaging studies and clinical findings for other primary lesions. This distinction is important because 5-year survival rates in such cases are higher than in metastatic cases (80-100 vs. 5-20%, respectively).