Amyloid Precursor Protein Dimers Precursor Protein Acts by Disrupting Neuroprotective Secreted Amyloid (original) (raw)

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

BMC Neuroscience, 2008

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

Pascal Kienlen-Campard

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

Christoph Weise

The EMBO Journal, 2007

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Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment

Alexander Arseniev

FEBS Letters, 2012

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Molecular Determinants and Thermodynamics of the Amyloid Precursor Protein Transmembrane Domain Implicated in Alzheimer's Disease

Davide Provasi

Journal of Molecular Biology, 2011

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Structure of amyloid precursor protein's transmembrane domain

E. Bocharov

2012

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What is the role of amyloid precursor protein dimerization

Pascal Kienlen-Campard

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Familial L723P Mutation Can Shift the Distribution between the Alternative APP Transmembrane Domain Cleavage Cascades by Local Unfolding of the Ε-Cleavage Site Suggesting a Straightforward Mechanism of Alzheimer’s Disease Pathogenesis

Anatoly Urban

ACS Chemical Biology, 2019

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Perturbations of the Straight Transmembrane -Helical Structure of the Amyloid Precursor Protein Affect its Processing by -Secretase

Thomas Lemmin

Journal of Biological Chemistry, 2014

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A model system to study intracellular trafficking and processing of the Alzheimer's amyloid precursor protein

Sandra I. Vieira

Neurodegenerative …, 2004

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Ab42

Christoph Weise

Embo J, 2007

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Contribution of Kunitz Protease Inhibitor and Transmembrane Domains to Amyloid Precursor Protein Homodimerization

Jean-christophe Renauld

Neurodegenerative Diseases, 2012

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Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

Pascal Kienlen-Campard

FEBS Open Bio, 2015

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Mechanism of the cleavage specificity of Alzheimer's disease -secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

Colin Masters

Proceedings of the National Academy of Sciences, 1999

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A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

Hoshi Chun

Proceedings of The National Academy of Sciences, 2009

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Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ

Georgia Dolios

Biochemistry, 2016

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Mutagenesis Identifies New Signals for -Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including A42

Ruth Perez

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A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer's beta -Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the alpha -Site

Yutaka Kirino

Journal of Biological Chemistry, 1998

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A helix-to-coil transition at the -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

Pascal Kienlen-Campard

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Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect -Secretase Cleavage of APP

Christoph Weise

Journal of Biological Chemistry, 2008

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Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts

Matthias Gralle

Progress in Neurobiology, 2007

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Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

Yewon Kwak, Yong Ran, Kevin Felsenstein, Pedro E Cruz

PLoS ONE, 2014

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Folding and Stability of the Extracellular Domain of the Human Amyloid Precursor Protein

I. Torriani

Journal of Biological Chemistry, 2003

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APP-BP1, a Novel Protein That Binds to the Carboxyl-terminal Region of the Amyloid Precursor Protein

Julie Korenberg

Journal of Biological Chemistry, 1996

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Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A and interfere with amyloid precursor protein (APP) transmembrane dimerization

Peter Hildebrand, Lisa Munter

Proceedings of the National Academy of Sciences, 2010

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{beta}-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic …

Martin Citron

Science, 1999

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Amyloid Precursor Protein Dimers Precursor Protein Acts by Disrupting Neuroprotective Secreted Amyloid (original) (raw)

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