Novel mutations target distinct subgroups of medulloblastoma (original) (raw)
This study explores the genetic landscape of medulloblastoma, a common malignant childhood brain tumor, by sequencing the genomes of 37 tumors and matched normal tissues. The research identifies 136 genes with somatic mutations across 56 additional tumors, with significant recurrent mutations found in 41 previously unassociated genes. Notably, these mutations impact the epigenetic machinery and chromatin remodeling factors critical to different medulloblastoma subgroups. The findings underscore the potential for targeted therapies that align with the specific genetic alterations driving each tumor subgroup, addressing current treatment limitations.