MS20 Aplications of crystallography in pharmaceutical sciences: from molecules to materials (original) (raw)

24 European Crystallographic Meeting, ECM24, Marrakech, 2007 Page s205 Acta Cryst. (2007). A63, s205 Chlorpropamide, 4-chloro-N-((propylaminocarbonyl)benzenesulfonamide, is an antidiabetic drug. Although the existence of several polymorphs of this compound was reported, by 2006, the crystal structure was solved only for one of them [1]. In 2006, we have initiated a systematic study of the crystallization of chlorpropamide from different solvents and from the same solvent under different conditions. Up to now, five polymorphs were obtained as single crystals, and for three of them crystal structures were solved [2-4]. The structures can serve as a very beautiful example of the polymorphism in a system with similar intermolecular hydrogen-bonds pattern, but different packing of molecules in different conformations. Different structures result in the pronounced differences in density (up to 5 %), IR-spectra, melting temperatures (several °C) and melting enthalpy (up to 15 %).

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