Correlation of thrombolysis in myocardial infarction (TIMI) risk score with extent of coronary artery disease in patients with acute coronary syndrome (original) (raw)
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Pakistan Armed Forces Medical Journal, 2021
Objective: To evaluate the correlation between thrombolytic in Myocardial Infarction risk score with the severity of coronary lesions found by coronary angiography during hospitalization in patients with non-ST elevation Acute coronary syndrome. Study Design: Cross sectional study. Place and Duration of Study: Adult Cardiology department, Armed Forces Institute of Cardiology & National Institute of Heart Diseases, Rawalpindi from Jul to Dec 2018.Methodology: Patients who had chest pain suggestive of angina or anginal equivalent symptoms and diagnosis of Acute Coronary Syndrome (ACS) were included in the study. Patients with Acute Coronary Syndrome were risk stratified with Thrombolysis In Myocardial Infarction risk scores and were further evaluated with coronary angiograms to assess the extent of coronary artery disease. Results: Total 115 patients were recruited in the study with mean age 57.08 ± 10.2 years. There were 87 (75.7%) male patients while 28 (24.3%) female patients. The ...
Saudi Journal of Internal Medicine
Background: One third of all deaths worldwide are attributed to acute coronary syndrome. The thrombolysis in Myocardial Infarction Risk Score is used to assess the risk of mortality and major adverse outcomes in this population. This study aimed to assess and compare the morbidity and mortality differences rate between Saudi and non-Saudi patients with acute coronary syndrome. Methods: This retrospective study was conducted at the coronary care unit of King Abdulaziz University Hospital. All acute coronary syndrome cases were enrolled and assessed using the thrombolysis in Myocardial Infarction Risk Score. Results: 242 cases were divided as 98 ST-elevation myocardial infarction cases and 144 unstable angina/non ST-elevation myocardial infarction. Among ST-elevation myocardial infarction patients 21 were Saudi patients and 77 were non-Saudi patients with the median thrombolysis in myocardial infarction risk score for Saudi was 5 and for non-Saudi 3.5 (P = 0.6). Unstable angina/non ST...
… Background: Thrombolysis In Myocardial Infarction (TIMI) risk score predicts adverse clinical outcomes in patients with non–ST-elevation acute coronary syndromes (NSTEACS). Whether this score correlates with the coronary anatomy is unknown. Objective: To determine the frequency of low, moderate and high TIMI risk score in patients of NSTE-ACS and to compare the frequency of two vessel coronary artery disease on angiography with low, moderate and high TIMI risk scores in patients of NSTE-ACS. Study design: This was a cross sectional study. Setting: Department of Cardiology, Gulab Devi Chest Hospital, Lahore. Duration: Six months. Patients and Methods: Total 170 patients were included in the study. Patients' selection was done with the help of a pre-defined inclusion and exclusion criteria. TIMI risk score was calculated for each patient and patients were categorized into low, moderate and high risk groups (as per operational definition). Patients were further evaluated with coronary angiograms to assess the double vessel CAD. All angiographies were performed by a single physician. Data analysis was done on SPSS version 17. Results: Mean age of our patients was 54.81±10.55 years. Gender distribution shows that there were 106(62%) male and 64(38%) female patients. TIMI score risk classification showed that among 50(29.4%) patients TIMI risk score was low, among 107(62.9%) patients it was moderate and in 13(7.6%) patients it was high. There were 105(62%) patients who had two vessel coronary artery disease. Among 105 patients who had two vessel coronary artery disease, 25(23.8%) had low TIMI score, 69(65.7%) had moderate and 11(10.5%) of the patients had high TIMI score. Conclusion: In patients with non-ST-elevation acute coronary syndrome undergoing cardiac catheterization, the TIMI risk score is significantly associated with two vessel coronary artery disease. So it should be recommended that a routine invasive strategy be carried in patients with moderate or higher TIMI risk score.
2009
BACKGROUND Effective risk stratification is integral to management of acute coronary syndromes (ACS). The Thrombolysis in Myocardial Infarction (TIMI) risk score for ST-segment elevation myocardial infarction (STEMI) is a simple integer score based on 8 high-risk parameters that can be used at the bedside for risk stratification of patients at presentation with STEMI. OBJECTIVES To evaluate the prognostic significance of TIMI risk score in a local population group of acute STEMI. METHODS The study included 160 cases of STEMI eligible for thrombolysis. TIMI risk score was calculated for each case at the time of presentation and were then followed during their hospital stay for the occurrence of electrical and mechanical complications as well as mortality. The patients were divided into three risk groups, namely 'low-risk', 'moderate-risk' and 'high-risk' based on their TIMI scores (0-4 low-risk, 5-8 moderate-risk, 9-14 high risk). The frequencies of complicati...
International Journal of Research in Medical Sciences, 2019
Background: The Thrombolysis in Myocardial Infarction (TIMI) risk score is purportedly an integral score for mortality risk prediction in fibrinolysis-eligible patients with STEMI. Attempt was made to evaluate the same by correlating risk stratification by TIMI score with hospital outcome of such patients.Methods: There were 145 cases of STEMI were studied and TIMI risk scores were calculated and analysed vis-à-vis various relevant parameters. The patients were divided into three risk groups: ‘low-risk’, ‘moderate-risk’ and ‘high-risk’ based on their TIMI scores. All patients received routine anti-ischemic therapy and were thrombolysed subsequently, monitored in ICCU and followed during hospital stay for occurrence of post-MI complications.Results: There were 79 patients (54.5%) belonged to low-risk group, 48 (33.1%) to moderate-risk group and 18 (12.4%) to high-risk group according to TIMI risk score. The mortality (total 17 deaths) was observed to be highest in the high-risk group...
American Journal of Cardiology, 2004
The Thrombolysis In Myocardial Infarction (TIMI) risk score predicts adverse clinical outcomes in patients with non-ST-elevation acute coronary syndromes (NSTEACS). Whether this score correlates with the coronary anatomy is unknown. We sought to determine whether the TIMI risk score correlates with the angiographic extent and severity of coronary artery disease (CAD) in patients with NSTEACS undergoing cardiac catheterization. We conducted a retrospective review of 688 consecutive medical records of patients who underwent coronary angiography secondary to NSTEACS. Patients were classified into 3 categories according to TIMI risk score: TIMI scores 0 to 2 (n ؍ 284), 3 to 4 (n ؍ 301), and 5 to 7 (n ؍ 103). One-vessel disease was found in patients with TIMI score 3 to 4 as often as in patients with TIMI score 0 to 2 (odds ratio [OR] 1.08, 95% confidence interval [CI] 0.74 to 1.56; p ؍ 0.66). However, 1-vessel disease was found more often in patients with TIMI score 3 to 4 than in patients with TIMI score 5 to 7 (OR 2.16, 95% CI 1.18 to 3.95; p ؍ 0.01), and in patients with TIMI score 0 to 2 than in those with TIMI score 5 to 7 (OR 1.99, 95% CI 1.08 to 3.66; p ؍ 0.02). Two-vessel disease was more likely found in patients with TIMI score 3 to 4 than in those with TIMI scores 0 to 2 (OR 3.96, 95% CI 2.41 to 6.53; p <0.001) and 5 to 7 (OR 2.05, 95% CI 1.12 to 3.75; p ؍ 0.004). Three-vessel or left main disease was more likely found in patients with TIMI score 3 to 4 than in patients with TIMI score 0 to 2 (OR 3.19, 95% CI 2.00 to 5.10; p <0.001), and in patients with TIMI score 5 to 7 than in patients with TIMI score 3 to 4 (OR 6.34, 95% CI 3.88 to 10.36; p <0.001). In patients with NSTEACS undergoing cardiac catheterization, the TIMI risk score correlated with the extent and severity of CAD. ᮊ2004
Thrombolysis in Myocardial Infarction Risk Score in an Observation Unit Setting
Critical Pathways in Cardiology, 2013
Objective: The Thrombolysis in Myocardial Infarction (TIMI) score is a validated tool for risk stratification of acute coronary syndrome. We hypothesized that the TIMI risk score would be able to risk stratify patients in observation unit for acute coronary syndrome. Methods: Study design: Retrospective cohort study of consecutive adult patients placed in an urban academic hospital emergency department observation unit with an average annual census of 65,000 between 2004 and 2007. Exclusion criteria included elevated initial cardiac biomarkers, ST segment changes on ECG, unstable vital signs, or unstable arrhythmias. A composite of significant coronary artery disease (CAD) indicators, including diagnosis of myocardial infarction, percutaneous coronary intervention, coronary artery bypass surgery, or death within 30 days and 1 year, were abstracted via chart review and financial record query. The entire cohort was stratified by TIMI risk scores (0-7) and composite event rates with 95% confidence interval were calculated. Results: In total 2228 patients were analyzed. Average age was 54.5 years, 42.0% were male. The overall median TIMI risk score was 1. Eighty (3.6%) patients had 30-day and 119 (5.3%) had 1-year CAD indicators. There was a trend toward increasing rate of composite CAD indicators at 30 days and 1 year with increasing TIMI score, ranging from a 1.2% event rate at 30 days and 1.9% at 1 year for TIMI score of 0 and 12.5% at 30 days and 21.4% at 1 year for TIMI ≥4. Conclusions: In an observation unit cohort, the TIMI risk score is able to risk stratify patients into low-, moderate-, and high-risk groups.