Asian Journal of Biochemical and Pharmaceutical Research Solid Lipid Nanoparticles: An Modern Approach (original) (raw)
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A Technical Review: Solid- Lipid Nanoparticle (SLN), Their Characteristics and Their Preparation
Asian Journal of Pharmaceutical Research and Development
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their struc...
Solid lipid nanoparticles are at the forefront of the speedily developing field of nanotechnology with numerous potential applications in drug delivery, clinical medicine and research as well as in other diverse sciences. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. Lipid nanoparticles offer the possibility to develop new therapeutics along with applicability for various routes such as oral, topical and parenteral. It acts as colloidal drug carriers for hydrophilic or lipophilic drugs. SLNs unite the advantages of polymeric nanoparticles, fat emulsions and liposomes. The ability to incorporate drugs into nanocarriers offers an innovative prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting.
Zenodo (CERN European Organization for Nuclear Research), 2023
Solid lipid nanoparticles (SLN) are the heart of nanotechnology's tremendous development, with multiple practical benefits in drug delivery and research. Because of their size-dependent properties, solid Lipid nanoparticles can be used to create innovative medicines. Drug conversion into nanoparticles provides a new drug delivery concept that could be used for drug targeting. As a result, solid lipid nanoparticles have great promise reaching the goal of targeted and sitespecific drug delivery. The goals, production techniques, advantages, limits are all discussed in this review. Scanning electron microscopy and measurement of particle size and zeta potential, dynamic light scattering are examples of appropriate analytical techniques for SLN characterization. By using novel drug formulation technologies, the drug delivery system focuses on the regulation of in vivo dynamics in order to enhance the efficacy and safety of the included pharmaceuticals. Lipids used in the development of Nano particulate dosage forms, such as fatty acids, triglycerides, vegetable oils, and their derivatives. Solid lipid nanoparticles (SLNs) are a type of lipid drug delivery method that is relatively new. They were created to solve some of the limitations with traditional drug delivery systems, such as low drug encapsulation efficiency and limited bioavailability of Biopharmaceutical Classification Systems (BCS) class II and IV medications. SLNs are made up of physiologically well tolerated substances and melt-emulsified lipids that are solid at room temperature that helps to enhance drug bioavailability ultimately results in better desired therapeutic effect.
A NOVEL REVIEW IN NANOPHARMA TECHNOLOGY-SOLID LIPID NANOPARTICLES
Solid lipid nanoparticles (SLN) are rapidly developing colloidal drug delivery systems in the field of nanotechnology. Due to their unique sizedependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. An incorporation of drugs into these nanocarriers offers drug targeting. Hence, there is a tremendous research is going on SLN toreach the goal of controlled and site specific drug delivery. In this article we focused on advantages, different preparation methods which are suitable for large scale production, evaluation and application of SLNs.
A SHORT-TERM REVIEW ON SOLID LIPID NANOPARTICLES
IJPSM, 2022
In recent years, Solid lipid nanoparticles (SLNs) have been given a lot of attention as a potential drug distribution alternative to existing colloidal dispersion technologies. The use of SLNs as a pharmaceutical carrier has gotten a lot of focus in recent years. Nanostructure lipid carriers and SLNs are non-toxic since they are biodegradable. SLNs have various distinct properties in terms of therapeutic uses. SLNs are lipid-based nanocarriers with sizes ranging between 10 to 1000 nanometers. Decomposition of the drug can be protected by the drug entrapped in a lipid, physical stability; controlled drug release and remarkable acceptability are all benefits of SLNs over traditional drug carriers. The capacity to incorporate pharmaceuticals into nanocarriers opens up a new paradigm in drug delivery that could hold enormous promise in terms of improving bioavailability while also allowing for controlled and sitespecific drug delivery. This article covers the manufacture and characterization of SLNs, as well as the administration and medicinal uses.
Solid Lipid Nanoparticles-A Breakthrough In Novel Drug Delivery System
Solid lipid nanoparticles (SLNs) are the superseding drug delivery system in the nanotechnology sphere. SLNs has been developed at the beginning of 1990s with potential applications in the field of pharmaceuticals, cosmeceuticals, clinical medicine along with research as a substitute to the traditional colloidal carrier systems such as emulsions, liposomes since they exclude those downsides of the traditional system. SLN s offers a great way for controlled drug delivery and site targeting drug delivery as well. This article gives general information about the solid lipid nanoparticles, their production procedures and characterization. In addition to that, the recent advancements of drug delivery systems using SLNs were reviewed.
A Review: Solid Lipid Nanoparticles
2021
Solid lipid nanoparticles (SLN) are one of the most rapidly evolving nanotechnology formulations, with numerous applications in fields such as drug delivery, clinical medicine, research, and a variety of other sciences. SLN are nanometer-sized spherical particles that are dissolved in water or aqueous surfactant solution and treated with lipophilic or hydrophilic drugs. Also improving the solubility and bioavailability of poorly soluble drugs can be done with biodegradable and bio acceptable polymers that can also resolve the harmful effects of traditional drug carriers. The different development strategies and their assessment were the subject of this review report. The major applications of SLNs, primarily targeted drug delivery, are discussed, as are the analytical methods used in SLN evaluations.
Research in Pharmaceutical Sciences, 2018
During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.
Solid Lipid Nanoparticles: A Review
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine, and research, as well as in other varied sciences. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. This review presents a broad treatment of solid lipid nanoparticles discussing preparation method, characterization, route of administration of SLNs, generally carried out. Aspects of SLN route of administration and the invivo fate of the carriers are also discussed.