Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability (original) (raw)
Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region
Johanna Avis
PNAS, 2012
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Structural basis for autoinhibition of Notch
Jon Aster, L. Sarov-blat
Nature Structural & Molecular Biology, 2007
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Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region
marc vooijs
Structure (London, England : 1993), 2015
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DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
Brendan D'Souza
The Journal of Cell Biology, 2007
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Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17
marc vooijs
Journal of Biological Chemistry, 2015
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Proteolytic Cleavage of Notch: “HIT and RUN”
marc vooijs
Current Molecular Medicine, 2011
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Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2
Jon Aster, Sarah L'Heureux
PLoS ONE, 2009
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Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo
Isaac Li
Nano letters, 2016
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Mutational and Energetic Studies of Notch1 Transcription Complexes
Cristina Bianco
Journal of Molecular Biology, 2008
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Faculty of 1000 evaluation for Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation
Johnavae Campbell
F1000 - Post-publication peer review of the biomedical literature, 2011
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Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage
marc vooijs
Journal of Biological Chemistry, 2009
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Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE
marc vooijs
Development, 2006
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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and -secretase
Emmanuelle Six, Yacine Laabi
Proceedings of the National Academy of Sciences, 2003
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Regulation of Notch1 signaling by delta-like ligand 1 intracellular domain through physical interaction
Jung-Soon Mo
Molecules and Cells, 2011
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Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization
Eric Schroeter
Journal of Biological Chemistry, 2004
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Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes
Yunsun Nam
Cell, 2006
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Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
Jon Aster
Nature Structural & Molecular Biology, 2010
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Endocytic routes to Notch activation
Martin Baroň
Seminars in Cell & Developmental Biology, 2012
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A Novel Proteolytic Cleavage Involved in Notch Signaling
Ana Cumano
Molecular Cell, 2000
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Unidirectional Notch signaling depends on continuous cleavage of Delta
Amir Sapir
Development, 2004
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Size-dependent protein segregation creates a spatial switch for Notch signaling and function
Anastasios Georgakopoulos
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The Folding and Structural Integrity of the First LIN-12 Module of Human Notch1 Are Calcium-Dependent
Wm. Barrett Simms
Biochemistry, 1999
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Multiscale modelling of Notch-mediated lateral induction
Tariq Abdulla, Ron Summers
2012
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Induction of notch signaling by immobilization of jagged-1 on self-assembled monolayers
Graça Almeida-Porada
Biomaterials, 2009
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Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
Ajay Chitnis
Development, 2005
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Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL
Didem Vardar-Ulu
Blood, 2009
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The Notch meeting: an odyssey from structure to function
Ajay Chitnis
Development, 2016
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Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes
Mina Xu
Molecular and Cellular Biology, 2006
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Control of Notch-ligand endocytosis by ligand-receptor interaction
Ulrika Marklund
Development, 2010
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The intracellular region of the Notch ligand Jagged-1 gains partial structure upon binding to synthetic membranes
Sándor Pongor
FEBS Journal, 2007
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