Hidden Synchronous Cervical Malignancy in a Case of Ovarian Cancer (original) (raw)
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Medicina
Background/Aim: Synchronous gynecological malignancies are rarely encountered, and most often these cases are represented by synchronous ovarian and endometrial cancer. The aim of this paper is to present the case of a 53-year-old patient who was diagnosed with synchronous cervical and ovarian cancer. Case presentation: The patient had been initially investigated for vaginal bleeding and was submitted to a biopsy confirming the presence of a cervical adenocarcinoma. Once the diagnostic of malignancy was confirmed, the patient was submitted to a computed tomography which revealed the presence of large abdominal tumoral nodules of peritoneal carcinomatosis and was submitted to palliative chemotherapy with poor response. Eighteen months later she developed intestinal obstruction and was submitted to surgery. At that moment, synchronous ovarian and cervical tumors were diagnosed. Total radical hysterectomy with bilateral adnexectomy, pelvic and para-aortic lymph node dissection, omentec...
Synchronous Primary Carcinomas of Cervix and Ovary: A Case Report
IOSR Journal of Dental and Medical Sciences, 2016
Synchronous tumors occur rarely in female genital tract, though it is one among potential sites for synchronous malignancies. In our case report a 36 year old female is diagnosed with two primary malignancies simultaneously; squamous cell carcinoma cervix and bilateral papillary cystadenocarcinoma ovary. Their distinct histological features and sparing of uterine corpus and fallopian tube helped in establishing the diagnosis as two separate primaries rather as metastatic spread of one primary malignancy. The objective is to strengthen the suggestion of thorough evaluation of whole female genital tract in case of suspected tumor, as secondary Mullerian system theory explains the possibility of synchronous cancer in female genital tract.
The Internet Journal of Gynecology and Obstetrics
We report a case of synchronous cervical adenocarcinoma with borderline mucinous ovarian tumourin a 22 year old virgin who presented with prolonged bleeding and dysmenorrhoea of four months duration. A transabdominal ultrasound demonstrated fluid in the endometrial cavity. This was confirmed by MRI pelvisrevealing adistended endometrial cavity with cervical stenosis. Evacuation revealed hematometra and the post evacuation uterine cavity is empty. She was discharged and subsequently presented at three months with acute urinary retention and heavy bleeding. A CT pelvisshowed complex bilateral ovarian cyst with minimal ascites, an enlarged paraaortic node at L2 and hematometrawith cervical stenosis. An exploratory laparotomy was performed with cystectomy, supracolicomentectomy with uterine and cervical biopsy. The histopathology shows bilateral borderline mucinous tumor of the ovary with metastatic omental nodules and primary well differentiated adenocarcinoma of the cervix. The subsequent CT thorax revealed metastatic pulmonary nodules. In view of advanced cervical adenocarcinoma, she was advised palliative chemotherapy with carboplatin and paclitaxel for six cycles. She has currently completed one cycle of chemotherapy. Conclusion:This case is one of the rare presentations of synchronous tumours of different histology with primary cervical adenocarcinoma and bilateral borderline ovarian tumour occurring in a virgin with atypical clinical presentation and rapid progression.
A Rare Case of Synchronous Ovarian Adenocarcinoma and Squamous Cell Carcinoma of Cervix
European Journal of Medical and Health Sciences, 2021
Synchronous tumours of gynaecological malignancies occur rarely and most of these cases are represented by synchronous ovarian and endometrial cancer. Synchronous malignancies of cervix and ovary are rare with poor prognosis. Only few cases of synchronous cancer of cervix and ovary are found in the literature as case reports. Here, we report a case of a 63 year old patient who was diagnosed with synchronous squamous cell carcinoma of cervix and high grade serous carcinoma of ovary in which her clinical presentation, investigation and intraoperative findings were atypical. Patient presented with postmenopausal bleeding and mass per abdomen. Pipelle sampling revealed squamous cell carcinoma of cervix. Examination under anaesthesia noted endocervical growth measuring 3×4 cm with endoluminal extension into the whole endometrial cavity. Computerized tomography (CT) imaging showed left ovarian mass measuring 10.0×11.7 cm. Uterine corpus involvement in this case mislead us to the initial d...
Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix – A Rare Case Report
Journal of Medical Science And clinical Research, 2018
Synchronous primary malignancies of the female genital tract are rare. Of the reported cases, the more common synchronous cancers are those involving the ovary and endometrium. Three primary malignancies occurring simultaneously are even fewer. We found only 14 such reported cases in pub-med indexed journals till date. The single most important criterion to call these neoplasms synchronous malignancies is that they should be histologically distinct and separated from each other by normal intervening tissues, with no evidence of metastasis. The prognosis for synchronous tumors is relatively better as concurrent tumors are detected early and are associated with a low histological grade. We are presenting a case report of a 36 year old woman who underwent surgery for complex left ovarian cyst. Intra-operative frozen section analysis of the ovarian cyst proved to be positive for malignancy. Histopathological examination of subsequent staging laparotomy specimen revealed co-existing small cell carcinoma of the ovary, well differentiated endometrioid adenocarcinoma of endometrium, and squamous cell carcinoma-in-situ of the cervix. To the best of our knowledge, simultaneous presentation of these three distinct histological patterns of gynaecological malignancies has not been reported earlier.
Bilateral ovarian serous cystadenocarcinoma metastasizing to cervix: a rare case report
International journal of reproduction, contraception, obstetrics and gynecology, 2018
Ovarian carcinoma is the second most common gynaecologic cancer and the leading cause of death from gynaecologic malignancy. Two-third of all malignant epithelial ovarian tumors are constituted by serous ovarian cystadenocarcinomas. It is generally observed that ovarian cancer tends to remain intraabdominal even in advanced cases and that dissemination is usually by invasion of adjacent viscera, diffuse intraperitoneal implantation, and metastatic involvement of aortic and pelvic lymph nodes. Metastasizes to the uterine cervix, vagina, or vulva in ovarian cancer is rare. The reverse i.e. ovarian metastasis from cervical tumor is rather more common. Published literature suggest that, patients with cervical metastases had associated malignant ascites, retroperitoneal lymph node involvement, and significant peritoneal carcinomatosis. Cervical metastasis in ovarian malignancies always indicates the advanced stage of tumor and multi-organ involvement, indirectly stating poor prognosis. The median survival in cases of ovarian cancer metastasizing to cervix is 4.4 months. Authors report a case of bilateral ovarian serous cystadenocarcinoma metastasising to posterior lip of cervix resulted in poor prognosis and proved fatal for the patient with review of published literature.