Clinicopathological Study of Leukaemia in Gauhati Medical College & Hospital , Assam , India : A One Year Retrospective Study (original) (raw)
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National journal of laboratory medicine, 2022
The study included 90 cases of all types of leukaemia, which were diagnosed over a period of one year, from June 2019 to June 2020. Institutional Ethical Clearance was obtained (No: 9440/SS/PG/MC/2019). Inclusion criteria: All age groups and newly diagnosed cases of leukaemia in the hospital were included in the study. Exclusion criteria: Patients undergoing leukaemia treatment were excluded from the study. Study Procedure Patients from Outpatient Departments (OPD) and Inpatient Departments (IPD) who met the inclusion criteria during the study period were enrolled in the study. The procedure and purpose of the study were explained to the patients in their language, and written informed consent was obtained. In the case of paediatric patients, consent was obtained from their legal guardian or parents. A complete clinical and haematological evaluation was conducted. Cases with suspicious clinical findings underwent peripheral smear
Journal of Laboratory Physicians
Objective The actual incidence and demographic profile of hematological malignancies are unknown in Bihar because of lack of population-based cancer registry (PBCR) data and specialized tertiary cancer center facilities. The objective of this study was to estimate the prevalence, clinico-hematological profile and subtyping of acute leukemia cases by retrospective medical records. Materials and Methods A retrospective study was conducted in the Department of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India, over 2 years from July 2019 to June 2021. A total of 176 cases with relevant clinical features and hematological findings were involved in the study. Medical records were studied and data were retrieved. Statistical Analysis Data were recorded and analyzed using SPSS version 25. Results A total of 176 cases with relevant clinical features and hematological findings were involved in the study. Acute myeloid leukemia (AML) was most prevalent (52.8%), foll...
Spectrum of acute and chronic leukemia at a tertiary care hospital, Haryana, India
International Journal of Research in Medical Sciences, 2016
Leukemia are of two types; acute and chronic. Acute leukemias are; acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In childhood, ALL is most common type than AML. In India, the incidence of ALL and AML are 35% and 15% of all hematological malignancies respectively. Chronic leukemias are classified into chronic myeloid leukemia (CML) and chronic lypmphocytic leukemia (CLL). 3,4
Spectrum of leukemia at tertiary care hospital
IP innovative publication pvt ltd, 2020
Introduction: Acute leukemia are characterized by clonal expansion of immature myeloid or lymphoid precursors (blasts). The blasts cells are known to replace the normal hematopoietic tissues and to invade other organs of the body as well. Anemia, hemorrhage and infections occurring due to bone marrow failure are the top three complications of acute leukemia & chronic leukemia. Materials and Methods: In this study the various types of leukaemia distribution carried out at tertiary care Hospital among various ethnic groups, in terms of types, age, sex. This retrospective study over a five years period between January 2014 to December 2018, carried out in the department of Pathology, at tertiary care Hospital. Diagnosis was done with the help of peripheral blood count, peripheral blood smear and bone marrow examination for morphology along with cytochemistry study whenever required. FAB classification is followed in the present study. Results: Different patterns of acute leukemia were reported, in the present study. According to haematological parameters, following cases of acute leukemia 128 cases (69.18%), & chronic leukemia of 55 cases (29.72 %) were reported. Also 47 cases (25.40%) & 8 cases (4.32%) were reported as CML & CLL respectively. Conclusions: The present study showed that AML is more common than ALL. It is observed that ALL is more common ly seen in children. The incidence of AML is higher in adults in comparison to children and decreases towards older age.
Curēus, 2024
Objective: This study aimed to examine the impact of leukemia and other cancers in India and to observe any changes over time. Methodology: Detailed estimates of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for 30 types of cancers in India were analyzed for 29 years from 1990 to 2019 as part of the Global Burden of Diseases (GBD) study. Data from all available sources were used to gather information on the overall burden of disease in India. Results: Cancer is a leading cause of death worldwide, with varying rates of incidence in India, making prevention and treatment a challenge. Because cancer is not a reportable disease in India, the overall burden estimate is still a work in progress. This study analyzed the impact of leukemia and other cancers in India, including trends in incidence, DALYs, and mortality related to all cancers and various malignancies. The causes of leukemia in India were also explored. Conclusions: The study found the trends of cancer types that account for the majority of leukemia-related and cancer-related DALYs, death, prevalence, and incidence in India. Among the four most frequent malignancies, such as leukemia, there was significant variation based on age. Over the last 29 years, mortality from chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) has decreased, while deaths from acute myelogenous leukemia (AML) and chronic lymphocytic leukemia (CLL) have increased steadily.
Investigation on the Prevalence of Leukaemia at a Tertiary Care Hospital, Lahore
2013
Introduction: Cancer in all forms is causing about 12% deaths throughout the world. After recent advances and improvement in treatment and prevention in cardiovascular diseases, tumour is an important cause of morbidity and mortality. 1 The incidence of leukaemia across the world is 1 per 100,000 annually. It contributes to 25% of childhood cancers. 2 The study was designed to investigate the Prevalence of Leukemia subtypes at Lahore General Hospital / The Graduate Medical Institute, Lahore and was carried out in the Bone Marrow Clinic. The study was cross – sectional prospective. The period of the study was two year from 01 June, 2010 to 30 June, 2012. Methodology: Complete blood counts, bone marrow aspiration and trephine biopsies were performed according to standard methods. Results: In a total of 45 cases of leukaemia, acute leukemia was more prevalent than chronic leukaemia. The ratio of acute and chronic leukaemias was 4:1. Male to female ratio was 1.3: 1. Most of the patients...
Pattern of occurrence of leukemia at a teaching hospital in eastern region of Nepal-a six year study
JNMA, Journal of the Nepal Medical …, 2009
Introduction: Pattern of leukemia is known to vary widely throughout the world. The characterization of distribution patterns of different subtypes of leukemia in Nepal needs further study. We wanted to study the leukemia pattern in our institute. Methods: A retrospective study of 196 cases of leukemia, diagnosed at BPKIHS, between January 1997 to December 2002 was done. We analyzed the pattern of leukemia at BPKIHS by morphological subtype, gender, age at diagnosis, time period of diagnosis (seasonality), and geographic distribution. Results: Morphological sub typing showed that 121 cases were of acute leukemia and 75 of chronic leukemia. Chronic myeloid leukemia constituted the single largest group comprising 35.2 % of all cases, followed by acute myeloid leukemia (28.57 %) and acute lymphoid leukemia (19.9 %). Maximum numbers of cases were from the lowlands while least number of cases were from the mountain districts. Results were compared with literature from Nepal and other countries. This is the second series of leukemia from Nepal. Conclusions: The data published in this study reflects the leukemia pattern in the eastern region of Nepal. The pattern and distribution of AML, CML, ALL was similar to that in the developed western countries while the lesser frequency of CLL was similar to that in Southeast Asian region.
Scenario of Acute Lymphoblastic Leukaemia in Gwalior Region
Journal of Evolution of Medical and Dental Sciences, 2016
BACKGROUND Leukaemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukaemia (ALL) constitutes about 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early diagnosis of this haematological malignancy can be helpful for prognosis of disease. AIMS AND OBJECTIVES The objectives of the present study were to assess frequency of presenting symptoms, laboratory data and prognostic factors in children with diagnosis of ALL. MATERIALS AND METHODS The present study (2014) was performed in the Department of Pathology of Gajra Raja Medical College, Gwalior, over a period of one year from October 2013 to September 2014. The blood samples were received from patients attending various Departments of Jayarogya Groups of Hospitals, a tertiary care hospital. RESULTS Out of the 37 cases diagnosed as Acute Lymphoblastic Leukaemia, 25 (67.57%) were male and 12 (32.43%) were female, (male:female ratio: 2.1:1); 43.35% of patients which comprises highest number of cases belonged to 11-20 years of age group. The most frequent presenting symptoms was fever (83.78%) followed by weakness (70.27%) and loss of appetite (27%), while most frequent presenting sign was pallor (86.48%) followed by lymphadenopathy (67.57%) and splenomegaly (48.65%)). Complete blood cell count was abnormal in all of the patients and pancytopenia was detected in 10.81% of the patients. Of all the patients, 91.89% had abnormal White Blood Cell (WBC) count at presentation with about 80% were presented with Leukocytosis. FAB L1 subtype was more common as compared to FAB L2 subtype. CONCLUSION In our study (2014), Acute Lymphoblastic Leukaemia was more prevalent in males than in females and more common in childhood than in adult. FAB L1 subtype was more common as compared to FAB L2 subtype.
2016
Introduction: Leukemias are neoplastic proliferations of haematopoietic cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Aims: To chart out the incidence of four major types of leukemias presenting for the first time to Hospital located in rural region. Methods: It was a prospective and retrospective study of 156 patients carried out in the department of Pathology located in rural area over a five years period between May 2006 and May 2011. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination for morphology along with cytochemistry study whenever required. Results: In this study, commonest leukemia was chronic myeloid leukemia (CML) followed by Acute lymphoid leukemia (ALL), Acute myeloid leukemia(AML) and then chronic lymphoid leukemia (CLL). Out of total 156 cases, 90 were male and 66 were females with Male: Female ratio is 1.36:1. Acute lymphoid leukemia was the most common type of leukaemia in the children and adolescents. Myeloid neoplasms were most common in adults. Conclusion: CML was commonest type of leukemia followed by acute lymphoid leukemia. Male predominance was seen in all types of leukemia and age has significant effect on type of leukemia.
Asian Journal of Pharmaceutical and Clinical Research, 2019
Objective: Cytogenetic plays an inevitable role in predicting the diagnosis of acute leukemia. The recurrent chromosomal aberrations in acute leukemia have provided critical insights into the pathophysiological mechanism of leukemogenesis. Cytogenetics findings at diagnostics provide important information for decision-making in both childhood and adult acute lymphoblastic leukemia (ALL). The cure rate for ALL is >80% in children and 35% in adults. Despite the therapeutic advances in ALL, several important biological and pathophysiological questions remain to be answered to achieve an accurate diagnosis, timely prognosis, and maximum therapeutic benefit. Methods: The present study was carried out at tertiary care hospital, New Delhi, India. A total of 144 newly diagnosed ALL patients were analyzed for clinicohematological profile, immunophenotyping, conventional, and molecular cytogenetics. Results: The study population was found to have normal karyotypes in most of the cases; how...