Multiple Electrodes Aggregometry - a New Method to Assess the Platelet Reactivity in Non-ST Elevation Acute Coronary Syndrome Patients (original) (raw)

2011

Abstract

REZUMAT ® (Dynabyte, Germany) to assess the posttreatment platelet reactivity. Patients were stratified into quartiles according to the ADP-induced platelet aggregation. Patients of the highest quartile (Q 4) were defined as the "low-responders". Results: Ten recurrent CV events occurred during the 1-month follow-up. Clinical CV events were significantly associated with platelet response to clopidogrel (Q4 vs. 1, 2, 3: OR (95% CI) 19.8 (4.4-90.8; P<0.001)). Conclusions: The MEA assessment of ADP and AA- induced platelet aggregation is a valuable method to identify the low-responders to dual antiplatelet therapy. The results correlated the values of the area under curve (AUC) determined by MEA with the clopidogrel low-responder status and with an increased risk of recurrent CV ischemic Introducere: Pacienţii cu sindroame coronariene acute fără supradenivelarea segmentului ST au risc inalt pentru apariţia de noi evenimente cardiovasculare (CV) ischemice. Determinarea stat...

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