Increase in the incidence of non-Hodgkin's lymphoma, clinical features and long-term follow-up (original) (raw)

An increase in the incidence of non-Hodgkin's lymphoma (NHL) was observed from 1980 to 1994, particularly among older patients and women. The average annual incidence rate risen from 5.5 to 8.6 per 100,000 persons, with significant increases in extranodal involvement and stage IV diagnoses. Prognostic factors impacting overall survival included histology, International Prognostic Index (IPI), largest site localization, and mediastinal involvement, highlighting the need for further attention in medical strategies for NHL.