Intestinal Lymph-Borne Factors Induce Lung Release of Inflammatory Mediators and Expression of Adhesion Molecules After an Intestinal Ischemic Insult (original) (raw)

Abstract

Background. Intestinal ischemia and reperfusion (I/R) is a documented cause of acute lung injury (ALI) and systemic inflammation. We previously reported that obstruction of thoracic lymphatic flow during intestinal I/R blunts pulmonary neutrophil recruitment and microvascular injury and decreases the systemic levels of tumor necrosis factor. Here, we consider the existence of a gut-lung axis promoting the induction of systemic inflammation, whereby drained intestinal lymph stimulates lung expression of adhesion molecules and matrix components and generation of inflammatory mediators.

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References (34)

  1. Berthiaume Y, Lesur O, Dagenais A. Treatment of adult respira- tory distress syndrome: Plea for rescue therapy of the alveolar epithelium. Thorax 1999;54:150.
  2. Kuzu MA, Koksoy C, Kuzu I, et al. Role of integrins and intracel- lular adhesion molecule-1 in lung injury after intestinal ische- mia-reperfusion. Am J Surg 2002;183:70.
  3. Van Soeren MH, Diehl-Jones WL, Maykut RJ, et al. Pathophys- iology and implications for treatment of acute respiratory dis- tress syndrome. AACN Clin Issues 2000;11:179.
  4. Bernard GR. Acute respiratory distress syndrome: A historical perspective. Am J Respir Crit Care Med 2005;172:798.
  5. Brun-Buisson C, Minelli C, Bertolini G, et al. Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. ALIVE Study Group Intensive Care Med 2004;30:51.
  6. JOURNAL OF SURGICAL RESEARCH: VOL. 176, NO. 1, JULY 2012
  7. Aprahamian CJ, Lorenz RG, Harmon CM, et al. Toll-like recep- tor 2 is protective of ischemia-reperfusion-mediated small-bowel injury in a murine model. Pediatr Crit Care Med 2008;9:105.
  8. Edgerton C, Crisp ın JC, Moratz CM, et al. IL-17 producing CD4þ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin Immunol 2009;130:313.
  9. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004;202:145.
  10. Ley K, Laudanna C, Cybulsky MI, et al. Getting to the site of in- flammation: The leukocyte adhesion cascade updated. Nat Rev Immunol 2007;7:678.
  11. Nathoo N, Barnett GH, Golubic M. The eicosanoid cascade: Pos- sible role in gliomas and meningiomas. J Clin Pathol 2004;57:6.
  12. Caughey GE, Pouliot M, Cleland LG, et al. Regulation of tumor necrosis factor-a and IL-1b synthesis by Thromboxane A2 in nonadherent human monocytes. J Immunol 1997;158:351.
  13. Crooks SW, Stockley RA. Leukotriene B4. Int J Biochem Cell Biol 1998;30:173.
  14. Bowton DL. Leukotriene B4, acute respiratory distress syn- drome, and outcomes. Crit Care Med 2000;28:262.
  15. Magnotti LJ, Upperman JS, Xu DZ, et al. Gut-derived mesen- teric lymph but not portal blood increases endothelial cell perme- ability and promotes lung injury after hemorrhagic shock. Ann Surg 1998;228:518.
  16. Deitch EA, Adams C, Lu Q, et al. A time course study of the pro- tective effect of mesenteric lymph duct ligation on hemorrhagic shock-induced pulmonary injury and the toxic effects of lymph from shocked rats on endothelial cell monolayer permeability. Surgery 2001;129:39.
  17. Von der Weid PY, Muthuchamy M. Regulatory mechanisms in lymphatic vessel contraction under normal and inflammatory conditions. Pathophysiology 2010;17:263.
  18. Cavriani G, Domingos HV, Soares AL, et al. Lymphatic system as a path underlying the spread of lung and gut injury after in- testinal ischemia/reperfusion in rats. Shock 2005;23:330.
  19. Cavriani G, Domingos HV, Oliveira-Filho RM, et al. Lymphatic thoracic duct ligation modulates the serum levels of IL-1beta and IL-10 after intestinal ischemia/reperfusion in rats with the involvement of tumor necrosis factor alpha and nitric oxide. Shock 2007;27:209.
  20. Breithaupt-Faloppa AC, Vitoretti LB, Coelho FR, et al. Nitric ox- ide mediates lung vascular permeability and lymph-borne IL-6 after an intestinal ischemic insult. Shock 2009;32:55.
  21. Deitch EA, Forsythe R, Anjaria D, et al. The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock. Shock 2004;22:221. Erratum in 2004;22:491.
  22. Watkins AC, Caputo FJ, Badami C, et al. Mesenteric lymph duct ligation attenuates lung injury and neutrophil activation after in- traperitoneal injection of endotoxin in rats. J Trauma 2008;64:126.
  23. Deitch EA, Xu DZ, Kaise VL. Role of the gut in the development of injury and shock induced SIRS and MODS: The gut-lymph hy- pothesis, a review. Front Biosci 2006;1:520.
  24. Sudo LS, Leme JG. The inflammatory responses of rats depleted of lymphocytes or with an artificial obstruction of the thoracic duct. Br J Exp Pathol 1980;61:176.
  25. Coelho FR, Cavriani G, Soares AL, et al. Lymphatic-borne IL- 1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal i/r in rats. Shock 2007;28:694.
  26. Guth PH, Leung FW. Physiology of the gastric circulation. In: Johnson LR, Ed. Physiology of the gastrointestinal tract, second edition. New York: Raven Press, 1987:1031.
  27. Carmeliet P, Lampugnani MG, Moons L, et al. Targeted defi- ciency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999;98:147.
  28. Shasby DM. Cell-cell adhesion in lung endothelium. Am J Phys- iol Lung Cell Mol Physiol 2007;292:L593.
  29. Moraes TJ, Chow CW, Downey GP. Proteases and lung injury. Crit Care Med 2003;31:189.
  30. Raines EW. The extracellular matrix can regulate vascular cell migration, proliferation, and survival: Relationships to vascular disease. Int J Exp Pathol 2000;81:173.
  31. Souza DG, Coutinho SF, Silveira MR, et al. Effects of a BLT re- ceptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats. Eur J Pharmacol 2000;403:121.
  32. Ishitsuka Y, Moriuchi H, Isohama Y, et al. A selective thrombox- ane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung in- jury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs. J Pharmacol Sci 2009;111:211.
  33. Katagiri H, Ito Y, Ishii K, et al. Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice. Hepatology 2004;39:139.
  34. Tole S, Durkan AM, Huang YW, et al. Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1- dependent leukocyte adhesion. Am J Physiol Cell Physiol 2010;298:C1469.