Correlative study of fine n cytology and histopathology in intraabdominal lumps (original) (raw)
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Correlative study of fine n cyto logy and histopathology in intraabdominal
2014
Introduction: Intra-abdominal masses always remain (FNAC) preferably ultrasonographically guided (USG) of 50 cases of rrelated with histopathology. lumps. Material and Methods: guided FNAC was done in 40 cases. Under light microscopy the lesions were reported, cytohistopathological corr was done in 36 cases. Hematoxylin included. Maximum number of cases14 (28%) were in age group of 51 diagnostic yield was higher in USG guided FNAC. There were 24(48%) suggestive of malignancy,02(4%) nonneoplastic and06(12%) unsatisfactory smear. Hepatocellular carcinoma and Adenocarcinoma were the cytohistopathological correlation was90% as out of 40 cases 36 found various lesions of liver, lymph nodes. We have came across a rare lesion of Gaucher disease (2 cases) diagnosed successfully both by cytology and histopathology. Conclusion:
2016
Aim: To compare the diagnostic accuracies of ultrasound guided FNAC and ultrasound alone, considering histopathology as gold standard. Study design: Cross Sectional study. Setting: Histopathology Department, AIMCS, Lahore. Duration of study: One year from July 22, 2012 to August 13, 2013. Methods: Abdominal ultrasound, ultrasound guided FNAC and biopsy of 100 patients with clinical diagnosis of hepatobiliary masses were carried out. Results: Histopathologically, 92 masses were malignant (35 metastatic carcinomas, 53 hepatocellular carcinomas (HCC), 03 gallbladder adenocarcinomas and one cholangiocarcinoma) and 08 were benign abscesses. Ultrasound diagnosed 51 cases as HCC, 35 as metastatic, 03 gallbladder cancers, 01 cholangiocarcinoma and 10 as benign. FNAC revealed 91 malignant (35 metastatic, 52 HCC, 03 gallbladder adenocarcinomas, 01 cholangiocarcinoma) and 09 benign (08 abscesses, and 01 benign hepatocytes only). FNAC accurately diagnosed almost all the cases. Ultrasound correc...
Journal of Pharmaceutical Research International, 2021
Background: Deeply situated, solitary or nonpalpable lesions of abdomen are a common problem in surgical practice and are generally hard to evaluate. impair the quality of life and may have poor prognosis leading to higher mortalities. By using imaging technique difference between malignant and non-malignant lesions is generally done. USG guided FNAC of intra-abdominal masses is a good diagnostic modality to facilitate treatment planning. Histopathological correlation aids in sensitivity and specificity of Ultra sound guided FNAC thereby making it first investigation of choice for evaluation of intra-abdominal masses. This study attempts to assess the utility of Ultra sound guided fine needle aspiration cytology of intra-abdominal masses and their histopathological correlation. Methodology: This Prospective study will be conducted in Cyto-histopathology division of Department of Pathology, JNMC, Wardha. Total 30 patients with abdominal masses will be enrolled in the study. Fine n...
Hepatic, Splenic, and Bone Marrow Gaucheromas: A Case Series and Systematic Literature Review
Journal of Gastrointestinal and Liver Diseases
Background and Aims: Gaucher disease (GD) is one of the most common lysosomal storage diseases. It is characterized by the accumulation of glucocerebroside lipids in the macrophages, with liver, spleen and bone marrow frequently affected. The affected organs can develop tumor-like lesions (Gaucheromas), which are difficult to diagnose. We present the Gaucheromas and their ultrasonographic characteristics. Methods: We selected Gaucheromas and their ultrasonographic characteristics found in the last 5 years during the periodical evaluation of 74 adult GD patients in Romania. All the patients had magnetic resonance imaging examination for comparison. A systematic review of all the Gaucheroma-related articles was performed to compare our results with the literature. Results: Gaucheromas were found in 7 adult patients: 4 in the spleen, 2 in the liver and one affecting the bone. No malignancy ultrasound characteristics were found and neither on MRI exams. In the literature, 10 articles re...
IOSR Journals , 2019
USG guided FNAC is emerging, widely accepted, less invasive and cost effective safe diagnostic procedure with high sensitivity and specificity. Intraabdominal mass or focal lesion involving abdominal sites is often difficult for evaluation and remain an enigma for clinician. This study was done to evaluate the utility of USG guided FNAC to differentiate between malignant and nonmalignant lesion in various palpable and non palpable intraabdominal lesion. Aim: The aims of our study is to assess the usefulness of USG guided FNAC as a pre-operative diagnostic procedure in management of intra-abdominal lesions. Objective: The objective of our study is to assess the cytomorphological feature, age and sex distribution of the patients with various condition of intra-abdominal lesions, to classify the malignant according to their cell type and to evaluate the sensitivity, specificity and the diagnostic accuracy in different lesion wherever possible. Material and method: The study was done in Department of Pathology with collaboration of Radiology department, Patna Medical College and Hospital,Patna over a period of two year. The study was done on 100 patient of clinically and radiologically suspected intraabdominal masses. Result: Total 100 patient with intraabdominal mass were included in the study. Cases were reported in the age group of 13 month to 84 year. Of these 46 cases (46%) were male and 54 cases (54%) were female. The diagnostic yield of USG guided FNAC was 96%. Out of total aspirate; 79% were neoplastic and 17% were non neoplastic and 4% were categorized as inadequate.The study showed 92.3% sensitivity and 100% specificity with a diagnostic accuracy of 92.8%. Conclusion: USG guided FNAC is a simple, safe, rapid and highly accurate diagnostic procedure in differentiating benign from malignant lesion. It can be utilized as a pre operative procedure for the management of intra abdominal lesion.
Ultrasound-Guided Fine Needle Aspiration Cytology of Malignant Gallbladder Masses
Acta Cytologica, 1997
Background: The appropriate clinical management of various hepatic lesions depends on accurate diagnosis. Fine needle aspiration and cell block have gained popularity because they are convenient, minimally invasive, quick and have good performance profiles. Objective: To investigate the cytomorphological features of distinctive non-neoplastic and neoplastic lesions of the liver and to evaluate the sensitivity, specificity and diagnostic accuracy of ultrasound-guided (USG) fine needle aspiration cytology (FNAC) and cell block in the diagnosis of liver diseases at Khartoum Teaching Hospital. Method: A cross-sectional study was conducted at Khartoum Teaching Hospital, Sudan during the period of November 2008 to October 2011. One hundred and five cytological materials were collected from patients with focal liver lesions who referred after initial clinical and radiological assessment for ultrasound!guided fine needle aspiration cytology (USG-FNAC). Results: The age of the patients ranged from 5-60 years and 64 (61%) of these patients were males. Out of 105 investigated samples 76 (72.4%) and 41(39.0%) were malignant by cytology and cell block respectively. Out of these 105 samples, 71 were investigated by both cytology and cell blocks and were included in the final analyses of the FNAC in comparison to cell block. The sensitivity, specificity, positive predictive value and negative predictive value of the cytology were 100% (93.0 ! 100%), 63.3% (45.2 ! 79.0%), 78.8% (66.2 ! 88.3%) and 0 (0 ! 14.6%), respectively. Conclusion: Thus, USG-FNAC is a sensitive but not specific method in differentiating the benign and malignant focal liver lesions. Differentiation between primary liver malignant lesions and metastatic lesion needs adjunct techniques
Cytologic diagnosis of gallbladder lesions - A study of 150 cases
The Indian journal of surgery, 2010
Gallbladder (GB) carcinoma is among the five most common forms of gastrointestinal cancers and the diagnosis is usually made when the carcinoma is already in an advanced stage. The aim of this study was to assess the application of ultrasound (US) guided fine needle aspiration (FNA) in diagnosing GB carcinoma. The present study was carried out on 150 patients suspected to have GB carcinoma on ultrasonography. US-guided FNA from GB was done in these patients and FNA of the other organs was simultaneously done in 20 patients. Histopathology of the GB was available in 14 cases. Ultrasonography in these patients revealed mass/thickening of the wall of GB in 140 (93.3%) cases and nonspecific US findings in 10 (6.7%). Out of the 140 cases malignancy was cytologically diagnosed in 105 (75%) cases while 12 (8.5%) cases were inflammatory and 23 (16.5%) were inconclusive. Adenocarcinoma was the most common morphologic type. Metastatic tumor deposits were noted in FNA from space occupying lesi...
Fine-needle aspiration biopsy of hepatic lesions
Cancer, 2006
BACKGROUND. Computerized tomographic (CT)-guided fine-needle aspiration (FNA) cytology is a well-established tool in the diagnosis of hepatic lesions. Endoscopic ultrasound-guided FNA (EUS-FNA), developed recently and used predominantly in evaluating mediastinal and pancreatic lesions, provides access to a significant portion of the liver and to perihepatic structures not readily accessible by a percutaneous approach. A recent experience (1997-2002) with CT-guided FNA of liver lesions at the University of Alabama Birmingham (UAB) was compared with the first 2.5 years of EUS-FNA experience (2000)(2001)(2002). Cases were identified using a SNOMED search and all reports and cytologic slides were retrieved for review.
Diagnostic approach to needle biopsies of hepatic mass lesions
Diagnostic Histopathology, 2008
in clinical practice, a wide variety of benign and malignant lesions present as hepatic masses and are subjected to needle biopsy. for practical purposes, these lesions can be broadly classified into: (1) clearly hepatocytic and malignant; (2) clearly hepatocytic and of uncertain clinical nature and malignant potential; (3) clearly malignant and of uncertain lineage; and (4) neither clearly hepatocellular nor malignant. the diagnostic approach to each of these varies and requires integration of clinical, laboratory and imaging findings. Work-up often requires histochemical and immunohistochemical stains, which should be judiciously selected based on the h&e morphological pattern and the differential diagnosis. no single stain or standard composite panel of stains currently exists that is uniformly applicable. this review addresses appropriate triage of these biopsies and outlines a practical approach to the diagnosis of hepatic mass lesions, to encourage judicious use of resources, minimizing cost and time, and maximizing efficiency.
Key Role of Image Guided Fine Needle Aspiration Cytology in Diagnosing Intra-Abdominal Lesions
Annals of Pathology and Laboratory Medicine, 2020
Background: Masses in the abdominal cavity are often deep, non-palpable and palpable at times which can be inflammatory, benign or malignant. With increased sophistication of radiologic imaging techniques these deep seated lesions are detected more frequently and confirmed tissue diagnosis is essential for both planning of treatment and staging in case of malignant lesions. Image guided aspiration is an effective way to obtain diagnostic material and avoid diagnostic laparotomy. This study was conducted to categorize various intraabdominal lesions according to their site of involvement, study their cytomorphological features, and classify them as benign, malignant and inflammatory and assess the utility of image-guided cytology in the diagnosis of intra-abdominal lesions. Methods: This cross sectional study approved was done on image guided fine needle aspiration cytology smears of intra-abdominal masses. Age, sex and site details were retrieved from the archives. Hematoxylin and Eosin stained smears were reviewed by the Cytopathologist and diagnosis was arrived at after correlating with clinical and radiological data. Core biopsy or excision biopsy of the available cases were also reviewed and checked for correlation. Result: A total of 120 cases were studied with age ranging from 18-81years, 30% of patients were in the 61-70 years age group, followed by 27% cases in 51-60 years age group and 20% cases in 41-50 years age group. The male to female ratio was 1.03:1. 62.5% of cases were from hepatobiliary region, followed by 17.5% cases from pancreatic masses and 11 cases (9.16%) from ovarian masses. 80% cases were malignant, 10% were inflammatory cases, 9.2% cases were inconclusive and 1 (0.8%) benign lesion. Among the malignant lesions primary malignancies (Hepatocellular carcinomas and Adenocarcinomas) were more common than secondary deposits. This study showed 88.9% sensitivity, 83.3% specificity and 87.5% of diagnostic accuracy. Conclusion: Image guided aspiration of intra-abdominal lesion is a simple, economical, less complicated and less time consuming procedure that differentiates between malignant and non malignant conditions with high accuracy and can be used as pre-operative diagnostic procedure for planning further management of patient.