Association between level of HbA1c and lipid profile in T2DM patients attending diabetic OPD at BPKIHS (original) (raw)
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INDIAN JOURNAL OF APPLIED RESEARCH, 2021
Type 2 diabetes mellitus (T2DM) is a globally acknowledged health issue with its effect on human health, living standards, economy and health system. HbA C levels are routinely measured to monitor glycemic control. HbA C level 1 1 <7% is considered good glycemic control and HbA C level> 7% is considered poor glycemic control. Previous studies have reported that HbA C 1 1 level can be utilized as a possible biomarker for predicting dyslipidemia and consequent cardiovascular disease in diabetes mellitus patients. The aim of this study is to nd the association of lipid prole with HbA C in good glycemic control and poor glycemic control T2DM. This is a cross 1 sectional study conducted on 100 patients attending OPD with established diagnosis of T2DM of both sexes with no history of cardiovascular, renal or thyroid disease or history of lipid lowering drug intake. They were analysed for fasting (FBS) and postprandial (PBS) blood sugar, lipid prole and HbA C. Patients were classi...
Background: Diabetes mellitus (DM) is considered to be one of the most pervasive non-communicable disease. Diabetic patients with accompanied dyslipidaemia are soft targets of cardiovascular deaths. Glycated haemoglobin (HbA1c) which is chemically linked to sugar and it is considered a gold-standard measure of chronic glycaemia in diabetic patients. Changes in lipid profile is also well related with severity of DM as adjudged by HbA1c. Aims and objectives: To investigate the association of serum lipids with Glycated Haemoglobin in type 2DM patients. Materials and Methods: A cross-sectional study was conducted among the patients with a history of type 2 Diabetes mellitus for the past 10 years who were attending diabetic clinic at MES Medical College and hospital, Perinthalmanna, Malappuram district, Kerala. Anthropometric measures, blood pressure, fasting serum blood glucose (FBPS), postprandial blood glucose (PPBS), HbA1c, fasting serum lipids (total cholesterol, T-Chol triglycerides, TG, low density lipoprotein (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were registered for both cases and controls. Results: FBS, PPBS, HbA1C were significantly high in case group. LDL, CHOL, TG were high in case as compared to control group, HDL is significantly low compared to control group. HbA1C /LDL, HbA1C /HDL, HbA1C /CHOL statistically strongly significant results in patients when compared to controls. HbA1c is significantly associated with lipid profile of diabetic patients. Conclusion: Type 2DM patients are more prone to dyslipidaemia. Hence HbA1c can be considered as an indirect predictor for dyslipidaemia in addition to as a biomarker for glycaemic control
A STUDY ON CORRELATION BETWEEN HBA1C AND SERUM LIPID PROFILE AMONG TYPE 2 DIABETES MELLITUS
National Journal of Medical Research, 2021
Objective: To study correlation between HB1C and serum lipid profile among type 2 diabetes mellitus. Methods: The cross-sectional study was carried out on 146 patients above the age of 30 years presenting with type 2 diabetes in OPD/wards of medicine department at Tertiary Care Center, South Gujarat. Result: In study the parameters Fasting blood sugar (FBS), Glycated hemoglobin (HB1AC), triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low-density lipoprotein (VLDL)were studied. LDL, TC, were high in poor glycemic control group (HB1C>7) as compared to good glycemic control group (HB1C<7), HDL is significantly low in poor glycemic control group. Conclusion: HB1AC is significantly correlated with lipid profiles. Type 2 diabetic patients are more prone to dyslipidaemia. Hba1c is significantly correlated with lipid profiles. So hba1c can be used as an indirect indicator of dyslipidaemia in type 2 diabetes in addition to as glycemic control biomarker.
Acta Diabetologica, 2007
Diabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths. An early intervention to normalize circulating lipids has been shown to reduce cardiovascular complications and mortality. Glycated hemoglobin (HbA 1c) is a routinely used marker for long-term glycemic control. This investigation is an attempt to evaluate the diagnostic value of HbA 1c in predicting diabetic dyslipidemia. Venous blood samples were collected from 2,220 type 2 diabetic patients (ages, 35-91 years; male/female ratio, 1.07). The sera were analyzed for HbA 1c , fasting blood glucose (FBG), total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL). The levels of HbA 1c did not differ significantly between males (8.33 ± 0.06%) and females (8.47 ± 0.07%), whereas female patients had significantly higher FBG (10.01 ± 0.13 mmol/l) than males (9.31 ± 0.11 mmol/l). HbA 1c showed direct and significant correlations with cholesterol, triglycerides and LDL and inverse correlation with HDL. Female diabetic patients had significantly higher levels of serum cholesterol (5.42 ± 0.03 vs. 5.18 ± 0.03 mmol/l) and HDL (1.32 ± 0.01 vs. 1.12 ± 0.01 mmol/l) as compared to males. There was no significant difference in triglycerides and LDL between the two genders. Older patients ([70 years) had significantly lower FBG, cholesterol, triglycerides and LDL. There was a linear and significant increase in triglycerides in the patients of both genders with impaired glycemic control. Both male and female patients with worse glycemic control (HbA 1c [ 9%) had significantly high cholesterol and LDL levels. Serum HDL showed a significant and inverse relationship with uncontrolled hyperglycemia in females but not in males. These findings clearly suggest that HbA 1c can provide valuable supplementary information about the extent of circulating lipids besides its primary role in monitoring long-term glycemic control. Further studies are warranted to reinforce the potential of HbA 1c as a biomarker for screening of high-risk diabetic patients. Keywords Type 2 diabetes Á Dyslipidemia Á Glycemic control Á HbA 1c Á Serum lipids Á Biomarker
HbA1c – A predictor of dyslipidemia in type 2 Diabetes Mellitus
Pakistan Journal of Medical Sciences, 2020
Objective: This study was aimed to determine the predictive value of HbA1c in detecting dyslipidemia in patients with Type-2 Diabetes Mellitus. Methods: A total of 142 consecutive patients of Type-2 diabetes mellitus were recruited in this study after informed consent. The study was conducted for 6 months from January 2019 – June 2019 in Creek General Hospital, Korangi, Creek, Karachi. Demographic data and detailed history was taken. A complete systemic examination was done for any complications or co-morbids present and related investigations were performed including Fasting lipid profile (CHO, TG’s, HDL, LDL, CHO/HDL), serum HbA1c, Creatinine and ECG. Data is analyzed on SPSS 16 for mean, frequencies and correlations. Pearsons Chi square test is used for analyses of Correlation Results: In a total of 142 Type-2 diabetic patients 39(27.5%) were Males and 103(72.5%) were females with a male to female ratio of 1: 2.6. Mean age was 54.9yrs ± 10.7SD. Mean duration of diabetes was 7.37y...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Background: To investigate the association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus (T2DM) at a tertiary care hospital in Jeddah, Saudi Arabia (SA). Methods: The present retrospective cross-sectional study was accomplished at the Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, SA, between April and July 2018. There were 206 T2DM patients selected for the study (141 females and 65 males), and the data were collected through a review of the electronic profiles of patients by using the medical electronic file system used at the KAU Hospital. Biochemical data such as fasting plasma glucose (FPG), HbA1c and lipid profile, along with the patient's age, BMI and gender, were also taken from the electronic file system. The inclusion criteria allowed for only patients who were regularly seeing their physician and whose electronic file was up to date. Results: The participants' data were analyzed gender-wise. The females had significantly higher values for BMI (p=0.002), HbA1c (p=0.009), triglycerides (TGs) (p<0.001), high-density lipoprotein cholesterol (HDL-C) (p=0.002) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) compared to the males. The study subjects were grouped according to their level of HbA1c (good glycemic index <7%, and poor glycemic index >7%). In both groups, no significant differences were found in any of the parameters other than TGs (p=0.020) and HbA1c (p<0.001). An analysis of the correlation between HbA1c and other parameters exhibited a significant correlation with TG (r=0.16, p=0.020), while no significant relationship was observed with the other variables. The linear regression results indicated that HbA1c values were associated with TGs (p=0.020) and were independent of age, BMI, TC, LDL-C, HDL-C and FPG levels. Conclusion: The glycated Hb was associated with TGs, and no significant association was found with age, BMI, TC, LDL-C, HDL-C and FPG levels.
Cureus
Introduction: An unusually high blood glucose level is a hallmark of diabetes mellitus, with an imbalance between insulin levels and insulin sensitivity leading to an insulin functional deficit. Since it serves as both a risk indicator and a gauge of long-term glycemic control, the HbA1c concentration is a crucial component of standard diabetes treatment. The use of the HbA1c concentration in the diagnosis of diabetes is expanding as the test's accuracy increases. Dyslipidemic profiles can appear before type 2 diabetes manifests itself and are independent risk factors for the disease. Additionally, dyslipidemia, especially in diabetics, might affect pancreatic beta-cell survival and activity. This study was undertaken with the aim to find out any correlation between HbA1c and lipid profile among diabetics, prediabetics, and non-diabetics. Methods: A total of 1,000 individuals with age 18-60 years were included in the study (non-diabetics = 186, prediabetics = 238, diabetics = 576). HbA1c was estimated by capillary electrophoresis and a lipid profile was done using a fully automatic chemistry analyzer. Result: Diabetes was found to be significantly associated with dyslipidemia. In diabetics, a statistically significant increase in the level of triglyceride and very low-density lipoprotein (VLDL) was seen as compared to prediabetics. Diabetic women were found to be significantly more dyslipidemic as compared to diabetic males. The mean HbA1c among diabetics was found to be 8.3. Conclusion: In hyperglycemia-induced dyslipidemia, raised triglyceride and VLDL were the most common findings, and combined lipid abnormalities were more commonly seen as compared to a single abnormality in the lipid profile. Patients with poor glycemic control more commonly develop dyslipidemia, which may be a reason for an increased incidence of cardiovascular catastrophes in such patients.
2017
Background: Diabetes mellitus (type 2 DM) is now ranked first in health problems and its prevalence tends to increase worldwide. The Diabetes Control and Complication Trial (DCCT) study showed that lowering HbA1c rates may delay or prevent chronic complications. One of the risk factors for CHD in type 2 DM is dyslipidemia, i.e lipid metabolism disorders in the form of elevated total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and decreased levels of high-density lipoprotein (HDL). This study aimed to determine the correlation between HBA1C and blood sugar, as well as lipid profile in patients with type 2 DM. Subject and Methods: This was an analytic observational study with a cross-sectional design. The study was conducted at the Endocrinology and Metabolic polyclinic Pirngadi Hospital, Medan, North Sumatera, from January to February 2018. A total sample of 10 patients diagnosed as type 2 diabetes mellitus with obesity was selected for this study. The independent ...
Correlation observation between HbA1C and Lipid profile in Type II Diabetes Mellitus Out-Patients
International Journal of Pharma Research & Review, 2016
Diabetes mellitus the ticking bomb has multifaceted impact on the lifestyle of a patient. Apart from physical limitations and stress, Diabetes adds to economic burden for the patients. Diagnosis of diabetes mostly do not happen at the right time and many live with it till it was explored through the lab tests done when the patient goes for the treatment of some other ailment. This study was intended to look into the correlation between HbA1c and Lipid profile, so as if any correlation exists the same can lead to a decrease in the economic burden as well as can save many punctures done to the body of the already suffering patient using correlation coefficient. Many studies in the past had been done with the same objective and there are mixed results. In this southern part of India, where people are still not so cohesive with the health advisory of going for regular health check-ups after one reaches the age of 40 yrs., it was necessary to understand the correlation between HbA1c and ...
The correlation of HbA1c with body mass index and HDL-cholesterol in type 2 diabetic patients
Biomedical Research-tokyo, 2016
Glycosylated haemoglobin (HbA1c) is a routinely used marker for long-term glycaemic control. This study aimed to reveal the correlation of HbA1c with BMI and HDL-cholesterol in Type 2 diabetic Saudi patients. This is an observational hospital based-case control study that was conducted in Najran University Hospital (Najran, Saudi Arabia). Patient’s sera were used to measure the concentration of HbA1c and lipid profile. Significant differences between groups were assessed by one-way ANOVA and t-test. Pearson correlation was done and the r values were calculated at level of (p<0.05) significance. HDL-cholesterol was significantly lower in diabetic patients than in healthy non-diabetic control group. Pearson correlation coefficient of HbA1c in diabetic patients with BMI was statistically significant (in spite of being weak) at the 0.0001 level. Moreover, there was a statistically significant positive correlation between HbA1c and LDL-cholesterol (r=0.271, p<0.0001), between BMI a...