FT3 is Higher in Males Than in Females and Decreases Over the Lifespan (original) (raw)

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017

Abstract

Normal changes in Free triiodothyronine (FT3), Free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels over the lifespan and differences between genders are not well documented, mainly because even the largest-scale studies available include relatively small cohorts. The aim of this study was to define age-related trends including gender differences based on reliable data. A large database including serum thyroid tests drawn in community clinics was studied. Free T3 (FT3), free T4 (FT4) and TSH levels from 527,564 sera taken from patients age 1 year or greater were included. After highly extensive exclusion criteria applied in order to remove all samples that may have been taken from unhealthy people, 27,940 samples remained. These were stratified by decades of age and by gender. FT3 decreases throughout life, significantly more so among females, with equalization between genders in the elderly. FT4 declines, to a lesser extent, also more among females than among males. Am...

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