COVID-19 Prophylaxis Efforts Based on Natural Antiviral Plant Extracts and Their Compounds (original) (raw)
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Journal of Advances in Medicine and Medical Research, 2021
The menace of COVID-19 continues to ravage the world despite deployment of vaccines, and the development of oral antiviral pills whose effectiveness are still being evaluated. As the problems persist, Scientists are continuously searching for new resources and re-evaluating old ones that be used to effectively contain the pandemic. A search through literature has shown a huge amount of scientific resources in medicinal plant research which could be leverage. Many medicinal plants have been demonstrated to possess various antiviral activities against influenza virus, SARS-CoV, herpes simplex virus, vesicular stomatitis virus, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, simian immunodeficiency virus, echovirus, adenovirus, Newcastle disease virus, duck plague virus, measles virus, polio viruses, yellow fever viruses, Sindbis virus, human cytomegalovirus, Rift valley fever virus, feline herpesvirus, lumpy skin disease virus, and canine distemper virus. Medicina...
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In the recent years, there was an increasing demand for discovering antiviral agents from medicinal plants having high activity and economically cheap. The medicinal plants have become very important because they have a main importance for determination, isolation and purification of natural chemical compounds in order to use them in many medicinal application. The scientific researches proved that plants extracts have antiviral activity against corona virus . The explanation of this activity belongs to presence of active chemical compounds act to stop the viruses in living body by multi different mechanisms. This review will provide an overview about the perspective of used some various medicinal plants against corona virus as antiviral drug and compared with antibiotics to reduce/prevent corona virus risk. In conclusion of this review, some medicinal herbs required urgent extensive work to develop natural antiviral agents to fight corona virus (COVID-19). ...
Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities
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Today, the coronavirus epidemic, which caused the death of 79 million cases and 1743 thousand people in 218 countries around the world, continues to increase its impact all over the world. Researchers are still trying to develop an effective solution against covid-19, including vaccines and drugs. However, there are few studies that determine the effect of natural products obtained from plants on covid-19. Medicinal and aromatic plants have been used for therapeutic purposes since the existence of humanity. In this study, the effects of some important medicinal plants including Licorice (Glycyrrhiza glabra), Saffron (Crocus sativus L.), Nigella (Nigella sativa L.), Laurel (Lauris nobilis), Karabaş (Lavandula stoechas), and Zahter (Thymbra spicata L. var. Spicata) against Covid-19 were investigated in vitro conditions. The six plants were evaluated for cytotoxic effect on Vero cells and determining inhibition of viral replication in Vero-E6 cells at concentrations of broad-spectrum a...
Coronavirus disease (COVID-19): a review of antiviral potential herbal medicines
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In Wuhan, China, severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2) has emerged, causing serious symptoms in patients such as fever, dry cough, and exhaustion. This fatal pandemic spreads over the globe, causing significant infections in humans, mainly in the respiratory tract. COVID-19 is still without a treatment. Until date, researchers have paid close attention to new therapeutic methods, particularly promising antiviral medicines and vaccines. Especially, existing synthetic antivirals have been used against viruses that prevent replication, entry into the cell, and transmission of the virus. These antiviral agents have been the subject the basis of drug discovery studies that directly affect COVID 19. Therefore, we investigated on the potential herbal medicines against various RNA, and DNA viruses, including SARS-CoV-2. Finally, we recommend that natural substances and plants be investigated further, including clinical trials, for the treatment of COVID-19.
The antiviral properties of edible medicinal plants: potential remedies against coronaviruses
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SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is an unparalleled challenge for the international community. Subsequently, an extraordinary effort has been made to contain SARS-CoV-2. However, this has been largely limited to behavioral changes and vaccination. To make the containment strategies effective, behavioral changes and vaccination need to be complemented with alternative prevention methods and curative treatments. This work reports the antiviral properties of some of the commonly known edible medicinal plants that can be used as potential remedies to suppress coronaviruses. A growing body of evidence substantiates that edible medicinal plants with antiviral properties that have been proven effective against sibling coronaviruses likely contain the spread of SARS-CoV-2, and they may also suppress the fatality of COVID-19 (coronavirus disease 2019). The secondary metabolites found in herbal medicines do not cause pathogens to develop drug resistance, which is a...
Therapeutic opportunities of edible antiviral plants for COVID-19
Molecular and Cellular Biochemistry, 2021
The pandemic of Serious Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) that produces corona virus disease (COVID-19) has challenged the entire mankind by rapidly spreading globally in 210 countries affecting over 25 million people and about 1 million deaths worldwide. It continues to spread, afflicting the health system globally. So far there is no remedy for the ailment and the available antiviral regimens have been unsatisfactory for the clinical outcomes and the mode of treatment has been mainly supportive for the prevention of COVID-19-induced morbidity and mortality. From the time immortal the traditional plant-based ethno-medicines have provided the leads for the treatment of infectious diseases. Phytopharmaceuticals have provided potential and less toxic antiviral drugs as compared to conventional modern therapeutics which are associated with severe toxicities. The ethnopharmacological knowledge about plants has provided food supplements and nutraceuticals as a promise for prevention and treatment of the current pandemic. In this review article, we have attempted to comprehend the information about the edible medicinal plant materials with potential antiviral activity specifically against RNA virus which additionally possess property to improve immunity along with external and internal respiration and exhibit anti-inflammatory properties for the prevention and treatment of the disease. This will open an arena for the development of novel nutraceutical herbal formulations as an alternative therapy that can be used for the prevention and treatment of COVID-19.
has been the most devastating pandemic in human history. Despite the highest scientific efforts and investments, a reliable and certified medication has yet to be developed regarding to immune or cure this virus. However, while synthetic medications are gaining the focus of attentions, it appears from a significant number of recent studies that plant-based substances could also be potential candidates for developing effective and secure remedies against this novel disease. Citing such recent works, this review primarily demonstrates the antiviral potentials of medicinal plants for inhibiting human coronaviruses. It also shows the importance of antiviral plants substances, particularly in the development of a broad spectrum medication for coronaviruses including SARS-CoV-2 responsible for COVID-19.
In-vitro Antiviral Activity of Natural Products against Coronavirus Strains: A Systemic Review
2020
Coronavirus is a non-segmented, positive-sense RNA genome belonging to the family coronaviridae in the order Nidovirales Corona viral infections have created serious threats in the last couple of decades and recently claiming the death of thousands of human beings. Natural products provide a valuable and powerful resource of chemical compounds alkaloids, tannins, caffeine, biopterin, actinophnine, etc. displaying antiviral properties. The data was reviewed from various databases or search engines: PubMed, Science Direct, MedLine, Google Scholar, and Biomed central for published articles. The data inclusion criteria was natural products and their isolated and different synthetic compounds. Data duplication and titles or contents that do not meet the inclusion criteria and Reports on antiviral activities of natural products or their derivatives against other than CoV strains were excluded. We encountered 49 plants and 19 compound chemically defined natural molecules reported in the li...