Mung Bean Flour Increases Blood Folate Levels in Pregnant Mice Model of Cleft Lip and Palate (original) (raw)

2021

Abstract

To analyse mung bean flour (MBF) administration to increase blood folate levels in pregnant mice models of cleft lip with or without cleft palate (CL/P). An experimental study was conducted using Balb/C mice. Pregnant mice were randomly separated into five groups. The mice that received distilled water were used as negative control (C), while mice in the other four groups (one positive control group (C+) and three treatment groups) were given with phenytoin of 60 mg/kg at gestational day (GD) 10 intraperitoneally and the three treatment groups were added with MBF 0.25 g, 0.5 g and 1 g/day, respectively. The MBF was given from GD 0 until the sampling data were collected at GD 17. Blood folate levels in T1 (0.25 g/d MBF), T2 (0.5 g/d MBF) and T3 (1 g/d MBF) groups were higher than those in Cand C+ groups. Anova test results on the comparison of the effect of MBF on blood folate levels in mice showed a significant difference with p = 0.037 (p <0.05). There was a significant differen...

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