Analogous feature of cemento-ossifying fibroma and bone pathology: a clinico-pathological correlation (original) (raw)
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Benign Fibro-Osteo-Cemental Lesions of the Craniofacial Complex – A Review
IOSR Journal of Dental and Medical Sciences, 2014
Benign fibro-osseous lesions of the craniofacial complex are grouped together under the generic term 'Fibro-osteo-cemental lesions'. These lesions are characterized by pathologic ossifications and calcifications in association with a hypercellular fibroblastic marrow element. The concept of the 'Fibroosseous lesions' of bone has evolved over several decades to include two major entities : Fibrous dysplasia and ossifying fibroma. Other dysplastic bone lesions of the craniofacial complex include florid osseous dysplasia, focal cemento-osseous dysplasia and periapicalcemental dysplasia.
Head and Neck Pathology, 2021
In the cranio-facial skeleton, a heterogeneous group of well characterized fibro-osseous lesions can be distinguished. Whereas fibrous dysplasia can affect any skeletal bone, ossifying fibroma and cemento-osseous dysplasia exclusively develop in the cranio-facial region, with most subtypes restricted to the tooth bearing areas of the jaws. Herein we present a series of 20 fibro-osseous lesions that developed mostly in the frontal bone and in the mandible, presenting as expansile intramedullary tumors with a unique histologic appearance and an indolent clinical course. We provide evidence that these tumors are distinct from the categories included in the WHO classification and are therefore currently unclassifiable. The definition of cemento-ossifying fibroma as an odontogenic neoplasm developing only in close proximity to teeth should be re-considered and incorporate also extragnathic lesions as shown here.
Fibroosseous Lesions of the Craniofacial Region: A 14 Year Experience
West Indian Medical Journal, 2016
Introduction: Fibro-osseous lesion (FOL) is a broad term for a diverse group of jaw and craniofacial disorders that are often painless but grow progressively if uncontrolled. They are characterized by the replacement of normal bone by fibrous connective tissue matrix displaying varying degrees of mineralization in the form of woven bone or cementum-like structures. Patients and Methods: Retrospective survey of the records of all patients seen between 2000 and 2013 at the department of Oral and Maxillofacial Surgery clinic, Ahmadu Bello University Teaching Hospital Zaria, Nigeria was undertaken. Results: A total of 104 patients were seen over the period of study. Of these, males comprised 40 and female, 64 giving a male to female ratio of 1:1.6. The age ranged from 4-66 years, mean 25.8 (13.21) years. There was no gender difference in terms of age (t=1.78; P=0.078). Fibrous dysplasia was the most predominant lesion and accounted for 60 (57.7%) of the cases and this was followed by os...
Ossifying fibromas of the jaws and craniofacial bones
Diagnostic Histopathology, 2015
Fibro-osseous lesions include a large group of pathologic processes in which normal bone is replaced by fibrous tissue containing variable amounts of mineralised material. Due to considerable similarity of features, definitive diagnosis of these lesions requires an accurate correlation of the clinical, radiographic and histopathological findings. Ossifying fibroma is a fibro-osseous neoplasm that commonly affects the jaw bones and comprises three distinct entities, all with overlapping features. We review the clinicopathologic and radiographic features of cemento-ossifying fibroma (COF), juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma (JPOF). Keywords cemento-ossifying fibroma; fibro-osseous lesions; juvenile ossifying fibroma; juvenile psammomatoid ossifying fibroma; juvenile trabecular ossifying fibroma; ossifying fibroma MINI-SYMPOSIUM: PATHOLOGY OF THE JAWS
Fibro-osseous lesions of craniofacial bones in children: case reports
Acta medica Lituanica, 2013
The aim of this article is to present rare clinical cases of craniofacial fibro-osseous lesions in pediatric patients. Materials and methods. In this report we present 3 cases of fibroosseous craniofacial lesions in pediatric patients. Lesions of bones resembled fibrous dysplasia, dysplastic fibroma and chronic osteomyelitis which were confirmed or suspected by clinical signs, radiographic visualization methods and histopathological investigations for these patients. The diagnostic workup, treatment, follow-up procedures and a literature review are presented. Results and conclusions. Fibro-osseous lesions of the jaws and skull manifest in a similar pattern. Conditions are easily revealed upon examination and with the help of conventional diagnostics, however, differential diagnosis using only radiological imaging is impossible. Histological findings remain a tool of choice determining the treatment strategy and outcome of the patients but it is not always available due to anatomical and functional considerations. Treatment of fibro-osseous lesions of the face and skull is highly individualized and depends on various qualities of the lesion and the patient himself. All patients received palliative symptomatic treatment to alleviate their conditions and in all cases obtaining a histology specimen and surgical intervention for treatment of the lesion was considered as a treatment option only if it was seen being safe and as least traumatic as possible because of the functional and psychological importance of the craniofacial region.
Journal of Contemporary Dentistry, 2014
The term, fibro-osseous lesions, is used for a group of pathological disturbances encompassing developmental, reactive or dysplastic lesions and neoplasms characterized by replacement of normal bone architecture by tissue composed of collagen fibers and fibroblasts containing various amount of calcified tissue. The groups of the fibro-osseous lesions are best considered as a spectrum of processes arising from cells in the periodontal ligament. Juvenile ossifying fibroma (JOF) is a benign, but potentially aggressive, fibro-osseous tumor of the craniofacial bones. This uncommon neoplasm is distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation, potential behavior and the high tendency to recur. Clinically presenting as an actively growing lesion. Histopathologically consists cell rich fibrous stroma containing bands of cellular osteoid without osteoblastic lining together with trabeculae of more typical woven bone. Pathogenesis of JOF may be related to mutations of HRPT2 gene which may arises due to haploinsufficiency of the HRPT2 gene. Here, we reported a case of trabecular JOF (TJOF) which had variations in clinical, radiographic features and histopathological characteristics and it's etiopathogenesis in detail.
Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings
Clinical and Experimental Health Sciences, 2020
Cemento-ossifying fibroma, which is considered a benign mesenchymal odontogenic tumour of the jaws, is a type of fibro-osseous lesion characterized by slow growth and proliferation of fibrous cellular stroma containing osteoid, bone or cementum-like tissue. The aim of this study was to report a case of cemento-ossifying fibroma in the mandible with clinical, radiological, and histopathological findings and surgical treatment. A 37-year-old woman was admitted to our clinic with the complaint of gradually growing painless swelling in the right mandibular premolar area. Intra-oral examination revealed a bony hard and non-tender mass with intact overlying mucosa on the buccal and lingual aspects of the mandibular right premolar teeth. Periapical, panoramic, and cone beam computed tomography images revealed the presence of a multilocular hypodense lesion with bicortical destruction and expansion in the relevant area. Excisional biopsy of the lesion was performed and histopathological examination exhibited the definite diagnosis of cemento-ossifying fibroma. Clinical, radiological, and histopathological examination should be considered in the diagnosis and treatment planning of cemento-ossifying fibroma.
Cemento-Ossifying Fibroma- A Case Report
Advances in Cancer Prevention, 2016
Background: Cemento-Ossifying Fibroma (COF) is considered by most as relatively rare, benign, nonodontogenic neoplasm of the jaw bones and other craniofacial bones characterized by replacement of normal bone by fibrous tissue and varying amounts of newly formed bone or cementum-like material, or both. It commonly affects, adults between the third and fourth decade of life and often shows variations in clinical, radiographic, and histopathologic features, hence require different treatment options. Purpose: This paper attempts to diagnose a case of cemento-ossifying fibroma of the jaw not only based on clinical characteristics but also radiographic and histopathologic features as an adjunct. Case: The patient was diagnosed with cemento-ossifying fibroma, presenting its clinical presentation, diagnostic imaging and histopathology features, as well as its surgical treatment. Conclusion: The diagnosis of cemento-ossifying fibroma of the jaw can be established based on clinical, radiographic and histo-pathological features. It is a benign growth, considered to originate from the periodontal ligament and presents as a slow-growing lesion, but may cause deformity if left untreated. However, these tumors may exhibit variations in their neoplastic behaviours. It is often encapsulated and predominantly located in the mandible, and the definitive diagnosis of these lesions requires integration of its clinical, radiological and histological features. We present a case of cemento-ossifying fibroma in relation to the lower left one-third of the face, and its management.
Cemento-Ossifying Fibroma: Study of Radiographic Features of Six Cases
Iranian Journal of Radiology, 2009
HEAD AND NECK IMAGING Cemento-Ossifying Fibroma: Study of Radiographic Features of Six Cases Cemento-ossifying fibroma is an unusual benign non-odontogenic fibro-osseous tumor that is limited to the jaws and facial bones. Microscopically, some times the lesion may be confused with fibrous dysplasia, and in these cases the final definitive diagnosis requires evaluation of the radiographic configuration. In this article, the radiological features of six cases of histopathologically confirmed cementoossifying fibroma are described.