Lipid Nanoparticles at the Current Stage and Prospects – A Review (original) (raw)
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Research in Pharmaceutical Sciences, 2018
During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.
A SHORT-TERM REVIEW ON SOLID LIPID NANOPARTICLES
IJPSM, 2022
In recent years, Solid lipid nanoparticles (SLNs) have been given a lot of attention as a potential drug distribution alternative to existing colloidal dispersion technologies. The use of SLNs as a pharmaceutical carrier has gotten a lot of focus in recent years. Nanostructure lipid carriers and SLNs are non-toxic since they are biodegradable. SLNs have various distinct properties in terms of therapeutic uses. SLNs are lipid-based nanocarriers with sizes ranging between 10 to 1000 nanometers. Decomposition of the drug can be protected by the drug entrapped in a lipid, physical stability; controlled drug release and remarkable acceptability are all benefits of SLNs over traditional drug carriers. The capacity to incorporate pharmaceuticals into nanocarriers opens up a new paradigm in drug delivery that could hold enormous promise in terms of improving bioavailability while also allowing for controlled and sitespecific drug delivery. This article covers the manufacture and characterization of SLNs, as well as the administration and medicinal uses.
Solid lipid nanoparticles are at the forefront of the speedily developing field of nanotechnology with numerous potential applications in drug delivery, clinical medicine and research as well as in other diverse sciences. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. Lipid nanoparticles offer the possibility to develop new therapeutics along with applicability for various routes such as oral, topical and parenteral. It acts as colloidal drug carriers for hydrophilic or lipophilic drugs. SLNs unite the advantages of polymeric nanoparticles, fat emulsions and liposomes. The ability to incorporate drugs into nanocarriers offers an innovative prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting.
Current Drug Delivery, 2008
In the past decade, research in the area of nanodrug delivery has reached a new height with the advent of lipid based nanodrug delivery systems. Lipids being biocompatible and possessing diverse physicochemical properties have tremendous potential to enhance oral bioavailability of water insoluble drugs. Incorporation of a drug in lipid carriers is a smart approach to overcome problems related with conventional oral therapy. In recent years, two lipid based nanoparticles, namely solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are widely explored. SLN are spherical nanoparticles with a drug-containing solid lipid core stabilized with surfactants and formulated mainly to improve bioavailability of the drug molecules. Despite several advantages of SLNs, their major drawbacks include limited drug loading, drug leakage, and crystallization during storage. These drawbacks were avoided or reduced by the development of a new generation of lipid nanoparticles, the NLC, wherein a solid lipid is blended with liquid lipid. Modulation of drug release was added advantage with NLC formulations. The present review focuses on production techniques, characterization, release characteristics, stability, toxicity and potential applications of SLNs and NLCs.
A review of the preparation, characterization and application of nanostructured lipid carriers
International Journal of Research in Pharmaceutical Sciences
Lipid Nanoparticles have gained increased attention during the last few decades. These carrier systems offer many advantages over conventional drug delivery system, including protection of the entrapped active ingredient from environmental (pH) or physiological (immune system, enzymes) degradations, improved bioavailability, prolonged circulation time, sustained release of drug and site specific drug delivery, reduced dose and side effects. Solid Lipid Nanoparticles (SLN), has been reported as an alternative carrier system to liposomes. However, SLN show some disadvantages such as drug expulsion during storage, low drug loading and aggregation of the particles. Nanostructured lipid carriers are evolved as second generation lipid nanoparticles to overcome the limitations of SLN, by modifying SLN by incorporating liquid lipid to the solid matrix for better drug accommodation to increase drug loading and prevent drug leakage while preserving the physical stability of the formulation....
International Journal of Drug Delivery, 2016
Solid lipid nanopaticles (SLNs) emerged in early 1990s as a next-generation drug delivery system, an alternative to traditional colloidal carriers like liposomeÊs, polymeric nanoparticles, emulsions etc. Their size range is between 1 to 1000 nm and their biodegradable and inacceptable nature make them less toxic and thus better suited to patients. SLNs have got potential applications in pharmaceutical field, cosmetics, clinical medicine and other allied sciences. Presently, formulation scientists have been focusing on SLNs as colloidal drug carriers for incorporating hydrophilic as well as lipophilic drugs. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery which can be used for drug targeting. They hold great promise for reaching the goal of controlled and site specific drug delivery. Furthermore, SLNs have got advantage of being introduced in the body by oral, parenteral and topical routes. So the present review attempts to enlighten various lipids used in SLNs, manufacturing techniques as well as the potential applications through various routes for a variety of disorders. Furthermore, the manuscript also focuses on the fate of these lipids (constituents of SLNs) in the body and their way out (i.e. elimination).
LIPID BASED NANOPARTICLES: SLN/NLCS - FORMULATION TECHNIQUES, ITS EVALUATION AND APPLICATIONS
IJCIRAS`, 2019
This review represents the usage of SLN and NLCs regarding their advantages, formulation methodology, characterization and applications. If suitably investigated, SLNs/NLCS may open new prospects in therapy of complex diseases. Solid lipid nanoparticles (SLN) were formulated at the emergence of the 1990s as a replaced carrier system to emulsions, liposomes and polymeric nanoparticles. SLN are aqueous colloidal dispersions, the matrix of which consists of solid biodegradable lipids. Nanostructured lipid carriers (NLCs) are drug-delivery systems consists of both solid and liquid lipids as a core matrix. It was shown that NLCs has some advantages for drug therapy over conventional carriers, including higher solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery. SLN and NLCs are manufactured by techniques like high pressure homogenization, solvent diffusion method ultrasonication, solvent emulsification etc. Both SLN/NLCs have applications in for parenteral, nasal, respiratory, ocular, rectal, and topical, in chemotherapy, etc.
Solid Lipid Nanoparticle (SLN): A Modern Approach for Drug Delivery
Lipid nanoparticles were developed in the last decade of the last century as alternative carrier system to emul sions, liposomes and polymeric nanoparticles. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are the two main types of li pid nanoparticles. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization and applications. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers.
A Technical Review: Solid- Lipid Nanoparticle (SLN), Their Characteristics and Their Preparation
Asian Journal of Pharmaceutical Research and Development
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their struc...
Solid Lipid Nanoparticles: A Critical Appraisal
2014
A new concept in nanotechnology is that of Solid lipid nanoparticles (SLNs), i.e. lipid nanocrystals in water possessing a solid core into which drugs are incorporated. The SLNs combine the virtues of more traditional drug carriers such as liposomes or polymeric nanoparticles while eliminating some of their disadvantages, e.g. the issues of burst release and long term stability in the case of liposomes as well as the problems of residual solvents and bulk production in the case of polymeric nanoparticles. The use of nanoparticles as drug-carrier system is a very attractive possibility to achieve controlled drug release. A clear advantage of SLNs over polymeric nanoparticles is the fact that the lipid matrix is made from physiological lipids, which decreases the danger of acute and chronic toxicity. There are various types of solid lipid nanoparticles and can be prepared using several methods. The present review covers all the aspects of solid lipid nanoparticles including their hist...