Gastric adenocarcinoma with bone marrow carcinomatosis complicated with cancer related thrombotic microangiopathy: A case report (original) (raw)

Introduction: Thrombotic microangiopathy is a common complication in cancer patients. Thrombotic microangiopathy occurs in association with a variety of malignancies, especially adenocarcinomas. The prognosis is not as favorable as in classical thrombotic thrombocytopenic purpura (TTP). Presentation may be either at an early stage of cancer or associated with disseminated disease. Case Report: We report a case of a 38-yearold male affected by metastatic gastric adenocarcinoma, who first presented with thrombotic microangiopathy and melena. Esophagogastroduodenoscopy revealed advanced gastric cancer (AGC). The signet ring cell gastric cancer was diagnosed by biopsy. He was considered as cancer related thrombotic microangiopathy (CR-TMA). Despite receiving intensive therapy for CR-TMA, his clinical status worsened. Bone marrow biopsy led to a diagnosis of disseminated carcinomatosis of the bone marrow caused by AGC. Conclusion: Cancer related thrombotic microangiopathy is a devastating complication of malignant