Nuclear phosphoinositidase C during growth factor stimulation (original) (raw)
Nuclear phosphoinositidase C (PIC) plays a significant role during growth factor stimulation, specifically in the metabolism of polyphosphoinositides within the nucleus of Swiss 3T3 cells. This study provides evidence that the 13 isoform of PIC is localized in the nucleus and is stimulated by insulin-like growth factor I (IGF-I), which correlates with changes in nuclear diacylglycerol and inositol phosphates. The findings suggest that nuclear polyphosphoinositide turnover is an essential mechanism for initiating DNA synthesis in response to growth factors.