Rare findings in a common tumor: A case of complex fibroadenoma with secondary changes in a young female (original) (raw)
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Cystic fibroadenoma of the breast: a case report
Turkish Journal of Pathology, 2011
Fibroadenoma is the most common breast tumor in adolescent and young women. Fibroadenomas that consist of sclerosing adenosis, papillary apocrine metaplasia, epithelial calcifications, and/or cysts greater than 3 mm are considered as complex fibroadenoma. The relative risk of developing breast cancer in patients with complex fibroadenoma is increased, compared to women with noncomplex fibroadenoma. Extensive cystic degeneration in a fibroadenoma, so called "cystic fibroadenoma" is very rare. Herein, we present a case of such a lesion in a 43-year-old female who has been on follow-up for fibrocystic changes of the breast, and discuss both radiological and histopathologic differential diagnosis of this lesion with other cystic lesions of the breast, including cystic papilloma. The patient is free of disease after 17 months of clinical follow-up.
Complex fibroadenoma – A case report
International Journal of Biomedical Research, 2015
Fibroadenoma is the most common benign biphagic breast tumour which usually occurs in young women under 30 years of age. Fibroadenoma is termed as complex fibroadenoma when it contains cysts larger than 3 mm & there is presence of sclerosing adenosis, epithelial calcification or papillary apocrine changes. The reported case is a 26 years old unmarried girl from Majuli, Jorhat who presented with left sided painless mobile breast lump of 2 years duration. The lump showed presence of coarse calcification on chest Xray. FNAC of the lump revealed mostly calcified material with occasional ductal element. Histopathological study revealed occasional tubules lined by cuboidal epithelium, numerous cystic spaces of varying sizes with abundant connective tissue stroma showing hyalinization & extensive calcification. Histopathological diagnosis was made as 'complex fibroadenoma'. There is recurrence free follow up till date.
Histological changes associated with fibroadenoma breast
IP Archives of Cytology and Histopathology Research, 2018
Introduction: Being the most common benign tumor of the breast, fibroadenoma show considerable histologic changes. It is important to highlight them as some of the changes are associated with increased risk of breast cancer. Aims and Objectives: To study the pattern and histologic changes in fibroadenoma breast. Materials and Methods: Retrospective analysis of histopathology of 55 cases of fibroadenoma breast diagnosed between Jan 2017 to Jun 2018. The pattern, epithelial and stromal changes were examined. Result: Commonest age group involved was in 3rd decade. Pericanalicular pattern was the predominant pattern. Apocrine and cystic change was the commonest change in epithelium. Two cases (3.6%) showed features of complex fibroadenoma. Three (5.5%) cases showed foci of tubular adenoma. Epithelial hyperplasia was seen in 5(9%) of cases of which 2 were mild, 2 were moderate and one was atypical hyperplasia. Inflammatory infiltrate in stroma was frequently observed. Conclusion: Fibroadenoma showed variety of histological changes of which complex fibroadenoma and epithelial hyperplasia are significantly important which requires appropriate management and follow up.
2015
Fibroadenomas are the most common benign tumor of the br but the peak incidence seen in young adolescent women during the second and third decades of life. Fibroadenoma is a biphasic tumor, composed of an epithelial and a stromal component. Even though they are solitary le sions, multiple fibroadenomas can also occur especially in the older age group. Breast fibroadenomas seemed to display a wide spectrum of proliferative and non proliferative histologic changes. Of all these changes, carcinoma arising from fibroadenoma is a occurrence. Here, we have present standing multiple fibroadenoma in a postmenopausal women. Clinical and radiological features are not helpful in identifying carcinoma arising from fibroad the excised specimen should be done for the confirmation of the diagnosis.
Unusual Variants of Fibroadenoma Breast
Journal of Evolution of medical and Dental Sciences, 2013
UNUSUAL VARIANTS OF FIBROADENOMA BREAST DIAGNOSED ON CYTOLOGY Fibroadenomas are common benign breast tumours that display a characteristic morphology, although several epithelial and stromal variations exist which may pose a diagnostic difficulty. We are discussing a case series of four cases of benign fibroadenoma with morphological variations as observed on cytology smears in the department of Pathology, KGMU, Lucknow, UP. Juvenile fibroadenoma constitutes only 4% of the total fibroadenomas with incidence of 0.5% per year. Another very rare histological finding is the presence of multinucleated giant cells throughout the stroma of a benign fibroadenoma, more commonly found incidentally within the interlobular stroma of breast tissue. Similarly apocrine metaplasia has been found to be 28% in a case series (Arno Kuijper et.al) of 396 cases of fibroadenoma. It is important to identify these variants as they may be misinterpreted as malignancy.
Multiple Fibroadenomas in Single Breast
Journal of Case Reports, 2014
Fibroadenomas usually present as single lesion in breast and there are few reports in literature of multiple fibroadenomas in both breasts. Multiple lesions in single breast are seldom reported. We report a rare case of multiple fibroadenomas, 12 in number, in a young girl in left breast. Diagnosis was made ultrasonographically and with aspiration cytology. We managed to remove all lesions with 2 submammary incisions. There was no recurrence seen on follow up of 3 years. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (creativecommons.org/licenses/by/3.0) Conflict of interest: None declared | Source of funding: Nil | DOI: http://dx.
Multiple fibroadenomas in bilateral breasts of a 46-year-old Indian woman – A case report
International Journal of Surgery Case Reports, 2014
INTRODUCTION: Fibroadenomas are among the most common tumours of the female breast, occurring most frequently in women of child-bearing age, especially those under 30 years. PRESENTATION OF CASE: We report a case with a total of 27 fibroadenomas presenting bilaterally of a 46-year-old woman. The histopathologic and immunophenotypic features of the fibroadenomata are described. DISCUSSION: Most fibroadenomas are present as single mass, however the presence of multiple fibroadenomata can be seen in 15-20% of the patients. It has been reported that the average number of masses in cases of multiple fibroadenomas is 3-4 in a single breast but occurrence of more than five fibroadenomas in an individual patient is much less common. CONCLUSION: There are few reports of multiple fibroadenomas. We report this case hoping to expand the literature and to provide insight to aetiology of multiple fibroadenoma formation and advice on management.
Fibroepithelial Lesions in the Breast of Adolescent Females: A Clinicopathological Study of 54 Cases
The Breast Journal
Fibroepithelial lesions (FELs) are the most frequent breast tumors in adolescent females. The pubertal hormonal surge could impact the growth and microscopic appearance of FELs in this age group. In this study, we evaluate the morphology and clinical behavior of FELs in adolescents. We searched the 1992-2012 pathology data base for FELs in females 18 years old or younger (F ≤18 years). Seven FELs from 1975 to 1983 were also included. Three pathologists reviewed all available material. Patient (pt) characteristics and follow-up information were obtained from electronic medical records. Forty-eight F ≤18 years had 54 FELs with available slides. Thirty (67%) pts were Caucasian, 12 (27%) African-American, two (4%) Hispanic, one (2%) Asian; three were of unknown race/ethnicity. Median age at diagnosis was 16 years. Median age at menarche was 12 years; most (96%) FELs occurred after menarche (median interval 48 months). All patients underwent lumpectomy; one required subsequent mastectomy. The FELs were 34 fibroadenomas (FAs) (11 usual, 23 juvenile), and 20 phyllodes tumors (PTs) (16 benign, one borderline and three malignant). Eight (35%) juvenile FAs showed slight intratumoral heterogeneity. The mean mitotic rate was 1.3 mitoses/10 high-power fields (HPFs) (range, 0-6) in usual FAs, 1.8/10 HPFs in juvenile FAs, 3.1/10 HPFs in benign PTs, 10/10 HPFs in the borderline PT and 17/10 HPFs in malignant PTs. The mean follow-up for 29 pts with 33 FELs was 44 months. Two (10%) PTs recurred locally (a benign PT at 18 months, and a borderline PT at 11 months). Both recurrent PTs had microscopic margins <1 mm. Mitotic activity in FAs from adolescents can be substantial and this finding should be interpreted cautiously. Awareness of the morphologic features of FELs in adolescents is important to avoid overdiagnosis of PTs, which can lead to additional unnecessary and potentially disfiguring surgery. n
Incidental Detection of Carcinoma in Situ in Fibroadenoma of Breast in a Young Woman: A Rare Finding
Asian Journal of Pharmaceutical and Clinical Research, 2019
Fibroadenoma is the most common benign tumor of the breast in young females. Breast cancer arising within a fibroadenoma is a rare phenomenon. The incidence of carcinoma within a fibroadenoma is reported to be between 0.1% and 0.3% in a screened population, with a peak age of occurrence between the 4 th and 5 th decade. We present a case of 29-year-old female with ductal carcinoma in situ in a background of fibroadenoma. There is a low percentage of fibroadenomas harboring carcinoma; however, all breast lumps should be seriously managed; extirpation and histological examination is recommended.