Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA (original) (raw)
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Viral Hepatit Dergisi, 2014
Objectives: Hepatitis A is the most common type viral hepatitis in the world. We aimed to detect the incidence of acute hepatitis A (HAV) infection in Kırıkkale province in Turkey, which is placed among the developing countries. Materials and Methods: IgM Anti-HAV test were studied in serum samples collected from 4.088 children aged 0-18 years, who received a pre-diagnosis of acute hepatitis between January 2006 and December 2013. The cases were divided into the three age groups as 0-5, 6-11, and 12-18 years. Results: Out of 4.088 serologic examination samples, 299 (7.31%) were found to be positive for IgM anti-HAV. Seropositivity rate among the age groups were as follows: 7.69% in the 0-5 age group, 39.80% in the 6-11 age group, and 52.51% in the12-18 age group. Conclusion: Hepatitis A appears to predominantly infect adolescents and young adults in our country as in countries of intermediate hepatitis A endemicity. These kinds of studies will create a data source for studies evaluating vaccine efficacy throughout our country.
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Akademik Gastroenteroloji Dergisi, 2022
Background and Aims: Hepatitis A virus is a cause of acute viral hepatitis that infects millions of people worldwide each year and maintains its prominence in both adults and in childhood. The aim of this study was to determine the hepatitis A seroprevalence in different age groups in Çorum which is the reference center for northern part of central Anatolia and to make recommendations for hepatitis A vaccine according to age groups. Materials and Methods: This retrospective study was conducted between January 2017 and January 2020. Patients tested for anti-hepatitis A virus for any reasons were enrolled from the data of all patients admitted to our hospital which is the reference center of the region. Serum samples were analyzed by ELISA. S/CO values of ≥ 1.00 were considered positive for anti-hepatitis A virus immunoglobulin G and immunoglobulin M, respectively; results below this value were considered negative. Anti hepatitis A virus immunoglobulin G and anti-hepatitis A virus imm...
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Journal of Medical Virology, 2004
Hepatitis A is a common disease in developing countries and Albania has a high prevalence of this disease associated to young age. In spite of the occurrence of a unique serotype there are different genotypes classified from I to VII. Genotype characterisation of HAV isolates circulating in Albania has been undertaken, as well as the study of the occurrence of antigenic variants in the proteins VP3 and VP1. To evaluate the genetic variability of the Albanian hepatitis A virus (HAV) isolates, samples were collected from 12 different cities, and the VP1/2A junction amplified and sequenced. These sequences were aligned and a phylogenetic analysis performed. Additionally, the amino half sequence of the protein VP3 and the complete sequence of the VP1 was determined. Anti-HAV IgM were present in 66.2% of all the sera. Fifty HAV isolates were amplified and the analysis revealed that all the isolates were sub-genotype IA with only limited mutations. When the deduced amino acid sequences were obtained, the alignment showed only two amino acids substitutions at positions 22 and 34 of the 2A protein. A higher genomic stability of the VP1/2A region, in contrast with what occurs in other parts of the world could be observed, indicating high endemicity of HAV in Albania. In addition, two potential antigenic variants were detected. The first at position 46 of VP3 in seven isolates and the second at position 23 of VP1 in six isolates.
The epidemiology of hepatitis a virus infection in children, in Edirne, Turkey
European Journal of Epidemiology, 2000
Turkey is a middle endemic area with respect to Hepatitis A virus (HAV) infection. However, the frequency of this infection varies due to socioeconomic differences in various regions. The aim of this study was to detect the most likely age of exposure to HAV and factors affecting infection rates among children living in Edirne. A sample of 645 children between the ages of 0-19 living in Edirne were tested for total anti-HAV levels using ELISA method. A questionnaire on socio-economic status (SES), possible risk factors, and place of residence was completed for each child. Anti-HAV seropositivity was found to be 4.4, 25, 37.3 and 43.2%, in 2-5, 6-10, 11-14 and 15-19 age groups, respectively. Seropositivity was found to be increasing with age (p < 0.05). According to logistic regression analysis results; mother's education, SES of family, history of hepatitis in primary family members and the number of brothers or sisters were determined as factors increasing the seropositivity of HAV. Furthermore, HAV infection risk was found to be a decreasing function of income that is higher the income less likely the infection. These results showed that HAV infection rate in Edirne is in middle endemicity and the most likely way of exposure is transmission from family members. Although it requires further costeffectiveness studies, our results indicate that applying the HAV vaccination in early childhood would be beneficial to decrease the prevalence of the infection and prevent HAV epidemics.
Epidemiological shift of hepatitis A in central Adana, Turkey
The Turkish Journal of Gastroenterology, 2015
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Seroprevalence of hepatitis a and associated factors among 1-15 year old children in Eastern Turkey
International journal of clinical and experimental medicine, 2015
Hepatitis A is a common infectious disease during childhood worldwide. Recently, great deal of changes in the epidemiology has been reported. The seroepidemiologic studies of this infection are not sufficient in Eastern region of Turkey. To investigate the seroprevalence and association with socio-demographic variables of hepatitis A in 1-15 year old children in Van. This study was performed on 510 one to fifteen year old children from outpatient pediatric clinics in Yüzüncü Yıl University, Faculty of Medicine during last three months of 2009. Anti-HAV IgG was measured in sera by enzyme-linked immunosorbent assay. The information about subjects was recorded on standardized forms and a chart review survey was performed. The overall ratio for seropositivity was 54.9%. Statistical significance was found between hepatitis A seroprevalence and age, collective use of domestic items, fresh water resources, localization and type of toilet and the number of households. This study provided th...
Orvosi hetilap, 2005
Hepatitis A virus (HAV) is the most important cause of acute infectious hepatitis worldwide. In Hungary, the reported number of HAV infections decreasing in the last decades, however, in every year approximately 500-800 new cases occur. In Hungary, particularly in North East region not only sporadic cases but also outbreaks of HAV are happen from time to time. Serology is routinely used laboratory method for diagnosis of HAV infections, although, there was no direct molecular detection and sequence analysis for the circulating HAV strains in Hungary. Author's aims were to detection and genetic characterization of hepatitis A virus in outbreaks of hepatitis by molecular methods for reason of molecular epidemiology in Hungary. Sera samples from symptomatic patients were tested from two acute hepatitis outbreaks in two settlements (Hajdúböszörmény and Kázsmárk) in North East Hungary in 2004 by enzim-immunoassay (EIA) and reverse transcription-polymerase chain reaction (RT-PCR). Ser...
Seroprevalence of antibodies to Hepatitis A and E viruses in pediatric age groups in Turkey
Acta Microbiologica et Immunologica Hungarica, 2002
Hepatitis A and hepatitis E are enteric transmitted viral diseases occurring in epidemic and sporadic forms especially in developing countries. Previous studies in Turkey showed that most residents are infected with HAV by the second decade of life. Since HEV is generally transmitted by the same route as HAV we conducted a community-based seroprevalence study for HAV and HEV infection in Ahatli area in Antalya, Turkey where socioeconomic conditions are low. Anti-HAV total immunoglobulin was tested by using a microparticle EIA (Axsym-Abbott Lab). Anti-HEV IgG was assayed by a micro ELISA method (Genelabs-Singapore). Of the 338 sera tested, 112 (33.1%) were positive for anti-HAV total antibody. Anti-HEV Ig G was detected in three (0.89%) of the serum samples. Seropositivity rates of HAV in preschool and school children were 19.9% and 43.9% respectively (p<0.001). No antibody to HEV was detected in preschool children, while the prevalence of anti-HEV Ig G was 1.6% in children attending school. Our data showed that seroprevalence of anti-HAV is high among children samples but HEV infection appears to be relatively rare in pediatric age groups.