Clear Cell Variant of Extraosseous Calcifying Epithelial Odontogenic Tumor: Report of a case and Review of Literature (original) (raw)
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Clear cell variant of extraosseous calcifying epithelial odontogenic tumor: a case report
Journal of Oral Science, 2009
Calcifying epithelial odontogenic tumor (CEOT) is a benign epithelial odontogenic tumor occurring most frequently in the posterior part of the lower jaw. Extraosseous CEOT is one of the rarest forms of this tumor, and few such cases involving the maxillary gingiva have been reported in the literature. Here we present a case that showed progressive enlargement in the left maxillary gingival area over a period of 11 years. Clinical examination showed an ulcerated mass measuring 52 × 38 mm located adjacent to the lateral incisor and canine. Histologically, the tumor showed proliferation of sheets and cords of epithelial cells with granular, eosinophilic cytoplasm and round to oval nuclei. In other areas, the epithelial cells exhibited a clear, vacuolated cytoplasm and foci of eosinophilic, homogeneous material representing amyloid deposition. The present case of extraosseous CEOT with clear cells was considered to be a very rare form of this tumor. (J Oral Sci 51, 485-488, 2009)
Clear cell Cystic Variant of Calcifying Epithelial Odontogenic Tumor
Head and Neck Pathology
Calcifying epithelial odontogenic tumor (CEOT) is a solid, locally aggressive, benign odontogenic neoplasm characterized by sheets and nests of polyhedral epithelial cells exhibiting eosinophilic and less often clear cytoplasm, occasional nuclear pleomorphism without mitotic activity, calcifications, and deposits of amyloid. A cystic variant has been reported only twice. Herein, we present an additional example of cystic CEOT occurring in a 31-year-old male and featuring clear cell epithelial lining with deposits of amyloid and osteodentin.
Journal of Oral and Maxillofacial Pathology : JOMFP, 2021
Clear-cell tumors of the head and neck are biologically diverse consisting of benign, malignant and metastatic lesions. These tumors pose a diagnostic challenge. In the oral cavity, these may be derived from odontogenic/nonodontogenic epithelium or from mesenchyme or can be metastatic. Odontogenic tumors with clear-cell change are rare. Calcifying epithelial odontogenic tumor (CEOT) is a rare, benign, locally aggressive odontogenic epithelial tumor affecting the jaw. Here, we report a case of clear-cell variant of CEOT with its histopathological differential diagnosis. A 43-year-old male patient with swelling in his lower right back tooth region showed a well-defined radiolucent lesion with smooth corticated periphery on radiograph. On incisional biopsy, tumor showed small sheets, cords and islands of odontogenic epithelium with nests of clear cells with no evidence of calcification. A final diagnosis of CEOT was established by differentiating other odontogenic and nonodontogenic le...
Clear cell calcifying epithelial odontogenic tumor: A rare case report
Journal of Indian Academy of Oral Medicine and Radiology, 2008
The calcifying epithelial odontogenic tumor (CEOT) is a benign epithelial odontogenic lesion that accounts for less than 1% of all odontogenic tumors. Clear cell variant of CEOT is extremely rare with only fifteen cases documented till date. The occurrences of clear cells may prove to be a sign of increased tumor aggressiveness, indicating the need for a more radical surgical approach.
Clear cell calcifying epithelial odontogenic tumorA case report
Int J Oral Maxillofac Surg, 1992
Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm of the jaws, accounting for less than 3% of all odontogenic tumors. It rarely extends into the maxillary sinus. Till date, six cases involving maxillary sinus have been reported. In this paper, we report the seventh case of a 52-year-old male with CEOT in maxilla extending from distal surface of the right maxillary canine to retromolar area and involving maxillary sinus with no association with impacted teeth. The diagnosis was confirmed by aspiration cytology and histologically, the tumor was composed of sheets of epithelial cells, with areas of clear cell changes. The presence of clear cells in the histological sections, accounts for the aggressive nature of the tumor simulating the clinical appearance. Prevention of recurrence can be achieved by radical resection.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2009
A case of peripheral calcifying epithelial odontogenic tumor, clear cell variant, located on the right gingival maxilla of a 48-year-old woman, presenting as a 2.0-cm solitary, firm nodule was studied. Microscopically, it was composed of polyhedral and clear epithelial cells associated with amyloid-like deposition. The clear epithelial cells exhibited granules that were positive for periodic acid-Schiff, and the amyloid-like deposit stained with Congo red showed a green birefringence in the polarized light. Polyhedral and clear epithelial cells were immunopositive for AE1/AE3 and cytokeratin 14. Immunoexpression of fibronectin and types I and III collagen were different between the amyloid-like deposits and the connective tissue stroma. Tenascin surrounded epithelial cells located inside the amyloid-like deposits. Laminin and type IV collagen were immunodetectable around the strands, cords, and nests of epithelial cells. This report represents the seventh case of peripheral calcifying epithelial odontogenic tumor, clear cell variant. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:198-204)
Calcifying Epithelial Odontogenic Tumor
Case Reports in Pathology, 2013
The calcifying epithelial odontogenic tumor (CEOT) is a rare benign epithelial odontogenic neoplasm of slow growth that is locally aggressive and tends to invade bone and adjacent soft tissue. Here is reported the case of a 21-year-old female patient with a CEOT in the left mandibular posterior region. The computerized tomography in coronal plane revealed a hypodense lesion in the posterior region of the left mandibular body with hyperdense areas inside and was associated with element 37. An incisional biopsy of the lesion was performed and the histopathological analysis revealed the presence of layers of epithelial odontogenic cells that formed prominent intercellular bridges. A large quantity of extracellular, eosinophilic, and amyloid-like material and an occasional formation of concentric calcifications (Liesegang rings) were also found. The histopathological diagnosis was a Pindborg tumor. Resection of the tumor with a safety margin was performed and after 6 months of follow-up there has been no sign of recurrence of the lesion.
Cytologic Findings in Calcifying Epithelial Odontogenic Tumor
Acta Cytologica, 2005
Calcifying epithelial odontogenic tumor (CEOT), or Pindborg's tumor, is a rare, benign, odontogenic neoplasm first described by Pindborg in 1955. It is most commonly seen in the fourth and fifth decades of life, usually arises in the mandibular premolarmolar areas and accounts for approximately 1% of all intraosseous odontogenic tumors. This report describes the cytologic findings in a case of CEOT. Case A 62-year-old woman was referred to the ear, nose and throat clinic with a right maxillary mass. The fine needle aspiration (FNA) smears showed numerous calcifications; amorphous, eosinophilic material; and clusters of round epithelial cells embedded in a bloody background. The smears were diagnosed as suspicious for malignancy. Maxillectomy was done. The histologic sections were diagnosed as CEOT. Conclusion FNA findings of calcifying epithelial odontogenic tumor have been described rarely. The clusters of epithelial cells with prominent nucleoli are mistaken for features of a malignant tumor. (Acta Cytol 2005;49:533-536)
Oral surgery, oral medicine, oral pathology and oral radiology, 2013
To describe the clinicopathologic, immunohistochemical, and scanning electron microscopic features of 19 cases of calcifying epithelial odontogenic tumor (CEOT) in comparison to 4 cases of dental follicles containing CEOT-like areas (DF-CEOT). A collaborative Latin American retrospective study. CEOT and DF-CEOT showed a slight predilection for females, mostly affecting the posterior mandible. CEOTs were classified as epithelium-rich (8 cases), amyloid-rich (4), and calcification-rich (3), and 4 cases showed similar proportion of the 3 components. DF-CEOTs contained odontogenic epithelium, amyloid, calcification, and clear cells. Epithelial cells were positive for cytokeratins CK5 and CK19, E-cadherin, and syndecan 1 (CD138), and focally for amyloid A. In CEOT, amyloid was positive for CD138 and amyloid A, and calcification for CK5, CD138, and amyloid A. In DF-CEOT, calcification was positive for amyloid A. CEOT showed higher Ki-67 protein and minichromosome maintenance complex compo...
Head & Neck, 1994
The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm which was first described by Pindborg in 1955 and accounts for less than 1% of all odontogenic lesions. Recently, a clear cell variant of CEOT has been identified with only eight well-documented cases in the literature. We present an additional case of clear cell CEOT of the mandible and review the salient clinical, radiologic, and histopathologic features of this entity and CEOTs in general. The differential diagnosis of clear cell tumors in the mandible includes: clear cell odontogenic tumor, clear cell ameloblastoma (odontogenic carcinoma), metastatic clear cell adenocarcinoma, primary intraosseous mucoepidermoid carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, clear cell salivary gland tumors, and clear cell variant of squamous cell carcinoma. Because of the belief that clear cell odontogenic tumors are locally aggressive neoplasms, definitive resection of the entire mass with tumor-free surgical margins and long-term follow-up are recommended.