Effect of Glucose and Peripheral Glucose Regulation on Memory in the Elderly (original) (raw)
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Glucose effects on declarative and nondeclarative memory in healthy elderly and young adults
Psychobiology, 1997
Peripheral glucose ingestion enhances performance on explicit declarative verbal memory tasks in healthy elderly people. In the present experiment, healthy young and elderly adults were administered glucose (50 g) or saccharin followed by tests of declarative verbal memory (free recall and recognition of a word list) and a nondeclarative priming test (word-stem completion). In the elderly, glucose significantly enhanced performance on the declarative but not on the nondeclarative portions of the test. Performance by the young subjects was equivalent in the glucose and saccharin conditions. These fmdings, that glucose enhances memory for a declarative/explicit but not nondeclarative/implicit task, support the notion that declarative and nondeclarative memory systems are separate functional and anatomic systems.
Glucose enhancement of performance of memory tests in young and aged humans
Neuropsychologia, 1989
Recent findings indicate that glucose administration enhances memory processes in rodents. This study examined the effects of glucose on memory in humans. After drinking glucose-or saccharin-flavored beverages, college-aged and elderly humans were tested with modified versions of the Wechsler Memory Scale. Beverages and tests were administered in a counter-balanced, crossover design, enabling within subject comparisons.
Effects of glucose on memory processes in young adults
Psychopharmacologia, 1991
Recent studies suggest that glucose enhances memory in rodents and humans. The present experiment investigated the effects of glucose on memory performance and blood glucose changes in young adults (19-25 years). Subjects ingested (300 ml beverage) three doses of glucose (0, 30, 100 g) in a random, double-blind, triple crossover design. Thirty minutes post-glucose, subjects were shown nouns on a computer monitor and then administered recall and recognition memory tests. Blood samples were drawn at regular intervals. There was no effect of glucose on memory performance, and plasma glucose measures did not correlate with memory test scores. Statistical power was adequate to detect a medium effect. The results contradict the hypothesis that glucose enhances memory performance in young, healthy normal adults.
Behavioural Brain Research, 2002
Memory for a list of 20 words can be enhanced by preceding learning by consumption of 25 g of glucose, compared with consumption of an equally sweet aspartame solution (Psychopharmacology 137 (1998) 259; Psychopharmacology 157 (2001) 46). However, using this anterograde administration procedure, it is impossible to separate whether glucose affects encoding, consolidation, or retrieval. The present placebo-controlled, double-blind study investigated the effect of anterograde and retrograde administration on memory performance in healthy young participants. In order to evaluate whether post-acquisition administration of glucose can improve memory performance and to compare possible differences in the size of the effect, participants were administered 25 g of glucose immediately before or immediately after presentation of a word list. Moreover, in order to investigate whether the effect of glucose administration on memory performance is time-dependant, a third group received 25 g of glucose 15 min before learning the word list. Word-list recall was tested 30 min and 24 h after word list presentation. Measures of spatial memory performance and working memory were also evaluated. The results of this study showed that both pre-and postacquisition oral glucose administration (25 g) can improve memory performance. However, as the time interval between anterograde glucose administration and memory encoding increased, the glucose memory facilitation effect decreased. This study provides evidence that glucose enhances memory performance in healthy young people even when it is given after learning has taken place, and that this effect is observed at least up to 24 h after glucose administration. Moreover, it provides evidence that the effect of glucose on memory performance may be time-dependent, as the enhancement of retention was decreased when the administrationlearning interval was increased. #
Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type
Neurobiology of Aging, 1993
MANNING, C. A., M. E. RAGOZZINO AND P. E. GOLD. Glucose enhancement of memory in patients with probable senile dementia of the Alzheiraer's type. NEUROBIOL AGING. 14(6) [523][524][525][526][527][528] 1993.--Attempts to attenuate the severe memory deficits in patients with SDAT have been largely unsuccessful, particularly in patients at advanced stages of the disease. Recent evidence indicates that glucose administration enhances memory in generally healthy aged rodents and humans. The present experiment demonstrates that glucose administration improves memory in moderately to severely demented patients with probable SDAT. Glucose ingestion significantly enhanced performance on several tests including orientation, word recognition and recaU, narrative prose, and face recognition after glucose ingestion. Thus, the results extend enhancement of memory with glucose from generally healthy rodent and human populations to patients with probable SDAT.