Study on acute transfusion related adverse reactions in surgery department (original) (raw)
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Asian Journal of Transfusion Science, 2017
BACKGROUND: Use of blood and its components is lifesaving. However, their use is often associated with adverse events. OBJECTIVE: To analyze the pattern of adverse reactions associated with transfusion of blood and its components in pediatric and surgical patients at a tertiary care teaching hospital. MATERIALS AND METHODS: Patients receiving transfusion of blood or its components in a randomly selected unit each from Departments of Pediatrics, including thalassemia OPD and surgery, were monitored intensively for a period of 6 months. Clinical course, management, outcome, causality, severity, seriousness, and preventability of observed transfusion reactions (TRs) were analyzed. RESULTS: A total of 411 pediatric and 433 surgical patients received 594 and 745 transfusions respectively during the study period. Of these, TRs were observed in 69 (11.6%) children and 63 (8.4%) surgical patients. Majority of reactions in children (48, 69.5%) and surgical patients (51, 80.9%) were acute, developing within 24 h of transfusion. TRs were observed with packed cells (13.2%), cryoprecipitate (10%), platelet concentrate (14.3%) and fresh frozen plasma (1.3%) in pediatric patients and with packed cells (7.2%), whole blood (25%) and platelet concentrate (62.5%) in surgical patients. Most common TRs included febrile nonhemolytic TRs (FNHTRs) and allergic reactions. Reactions were more frequent in patients with a previous history of transfusion or those receiving more than one transfusion and in children, when transfusion was initiated after 30 min of issue of blood component. Majority of reactions were managed with symptomatic treatment, were nonserious, moderately severe, probably preventable and probably associated with the suspect blood component in both populations. CONCLUSION: Transfusion reactions in children and surgical patients are commonly observed with cellular blood components. Majority of reactions are acute and nonserious. FNHTRs and allergic reactions are the most common transfusion reactions. Risk of transfusion reactions is more in patients receiving multiple transfusions.
Journal of Evidence Based Medicine and Healthcare
BACKGROUND Blood transfusion is the transfusion of whole blood or blood components (packed cells or plasma only) into the blood stream or directly into the bone marrow. 1 It is carried out between individuals with compatible / identical blood groups, failure of which results in adverse transfusion reactions. An ATR (Adverse Transfusion Reaction) is an unfavourable reaction to the transfused blood/ blood component, the severity of which differs from person to person depending on the patient's susceptibility, degree of incompatibility and the type of reaction. 2
A Study on Adverse Transfusion Reactions in a Secondary Care Hospital of Rural India
Journal of Pharmaceutical Research International
Aims: The study aims to assess the incidence, causality, and severity of adverse transfusion reactions in patients transfused with blood or blood components at a secondary care referral hospital. Study Design: A prospective observational study was conducted in the secondary care referral hospital located in rural settings of Anantapur district, Andhra Pradesh, India. The study was conducted for a period of six months from May 2019 to October 2019 Methodology: All the patients transfused with blood or blood components in the hospital located in Andhra Pradesh during those six months study period were included. The transfusion reactions were reported to the blood bank in the Adverse Transfusion Reaction Report Form (ATRRF). Descriptive statistics were used to represent the adverse transfusion reactions. Results: From 2549 transfusions, 30 adverse transfusion reactions were reported (1.17%).Most of the reactions reported were febrile non-hemolytic transfusion reactions FNHTRs (73.3%) f...
Acute transfusion reactions in a district hospital: A 2-year retrospective review
Acute transfusion reactions in a district hospital; A 2-year retrospective review , 2024
Background: Blood transfusion is a life-saving intervention but carries numerous risks. It is therefore paramount to identify various adverse events associated with the procedure and to take stringent measures to reduce its occurrence. The aim of this study was to determine the incidence and analyse the type of acute transfusion reactions occurring in patients who required blood transfusion. Materials and Methods: This study was a retrospective review and analysis of all acute transfusion reactions reported to the blood bank of Methodist Hospital, Wenchi-Ghana from January 2021 to December 2022. Results: During the study period, a total of 5,857 units of blood were issued, out of which there was an incidence of 0.51% (n=30). Most acute transfusion reactions were observed in females and in patients between 26-45 years. The most common symptom was pruritus/itching (33.3%), followed by skin rash (23.3%) and urticaria (13.3%). Majority of the reactions were allergic (70%) followed by Febrile non-hemolytic transfusion reaction (20%). The frequency of transfusion reactions was significantly higher with packed red blood cell transfusion (50%). Conclusion: Sensitization of all health personnel involved in the transfusion chain and strict hemovigilance program enforcement will help in improving the safety of blood transfusion.
Asian Journal of Transfusion Science, 2017
CONTEXT: Blood transfusion services have achieved newer heights in the last decade, with developments in cellular techniques, component separation, and integration of molecular methods. However, the system of recording and reporting of the adverse events related to blood transfusion is developing countries like India is grossly inadequate and voluntary in nature. AIMS: This study was undertaken to analyze the retrospective data on adverse events related to blood transfusions in our hospital. SUBJECTS AND METHODS: This retrospective study was done to examine all the transfusion related adverse events reported in a Regional Blood Bank Transfusion Centre of North India over a period of 9 years. Adverse transfusion events related to whole blood, red cell concentrates (RCCs), and all other components were analyzed and classified on the basis of their clinical features and laboratory tests. Average rate of transfusion reactions with the components was also assessed. STATISTICAL ANALYSIS USED: Categorical variables were analyzed using the Chi-square test. P < 0.05 was taken to indicate a significant difference. RESULTS: During this period, a total of 1,60,973 blood/blood component units were issued by our blood bank to various departments of the hospital and 314 immediate transfusion events were reported. The rate of immediate transfusion reactions during the study was 0.19%. Average transfusion reaction rate with RCC was 0.25% with febrile nonhemolytic reactions being the most common type of adverse event (37.2%). CONCLUSIONS: Awareness should be increased among clinicians to correctly prevent, identify, and report transfusion-related adverse events. These measures should be implemented to increase blood transfusion quality and safety.
Bangladesh Journal of Medicine, 2021
Background:Transfusion of blood and blood products if employed safely, with intensive care can save manyvaluable lives. But a number of transfusion reactions may develop that are sometimesmore serious and life threatening.So this study was done to find out the most frequent and life threatening reactions that develop during transfusion. Methods: A Cross sectional descriptive observational study was performed at a tertiary care centre. Patients of 18 years and older irrespective of sexes who received blood and blood products due to different reasons between April 2020 to September 2020 were included in this study. A total of 96 patients were included in the study. Results:In thisstudy 11(11.5%) out of 96 patients had transfusion reactions of different types .Febrile non haemolytic reaction was the highest with 8 patients (8.33%),followed by Allergic reaction in 2 patients(2.08%) and Acute haemolytic transfusion reaction in 1 patient (1.04%).Among them 7(63.6%) reactions occurred with...
Acute blood transfusion reaction in a tertiary care hospital in Southern Punjab, Pakistan
International Journal Of Community Medicine And Public Health, 2019
Background: Blood transfusion is a lifesaving process but carries many risks. Majority of these had been reduced with better diagnostic and management strategies. But the risk of non-infectious adverse transfusion reactions though reduced but cannot be eliminated. Hemovigilance is the system to monitor such reactions.Methods: The objective of current study was to know the frequency of adverse transfusion reactions and to compare it with local and international data. Retrospective cross-sectional descriptive study was done in Ibn-e- Sina hospital. Adverse transfusion reactions reported to blood bank was analysed according to hospital protocol.Results: Out of 6050 blood transfusions 23 (0.38%) develop adverse transfusion reactions. Febrile nonhemolytic transfusion reaction was the commonest adverse event and whole blood was the component implicated.Conclusions: Adverse transfusion reactions are non-infectious complications of blood transfusion which in spite of all efforts cannot be a...
Journal of Blood Disorders & Transfusion, 2016
Background: Blood transfusion is the transfer of whole blood or blood components (red blood cells only or blood plasma only) into the bloodstream directly or into the bone marrow. Blood transfusion is carried out between two identical blood groups only, which otherwise (incompatible blood transfusion) results in agglutination or clumping of the blood leading to haemolysis of RBC and releasing the haemoglobin to the blood plasma. Blood and blood components: Blood is a liquid connective tissue that consists of blood plasma (liquid) and formed elements (red blood cells, white blood cells and platelets). Blood components are various parts of blood like Red Blood Cells, Granulocytes and plasma separated from one another by conventional blood bank method by centrifugation because of their different specific gravities. The different cellular components are Red Blood cell (RBC) or Packed Red cells (PCV), Leucocyte depleted Red cells, Platelet concentrate, Platelet Apheresis and Leucocyte depleted Platelet concentrate. The different plasma components are Fresh Frozen Plasma, Cryo-precipitate and Cryo-poor Plasma. Indications for blood and blood component transfusion: Some of the conditions that demand the transfusion of blood and blood components are red cell replacement in anemia, acute or chronic restoration of oxygen carrying capacity, IgA deficiency, Thrombocytopenia, loss of blood during surgery and delivery and clotting factor deficiency. Common problems during blood transfusion: Blood transfusions are associated with adverse reactions during or after the transfusion. The blood transfusion reactions are classified based on the onset of the reaction, acute-immediate and delayeddays to weeks to months. The reactions are as follows:
Asian Journal of Transfusion Science, 2011
Aim: This study was designed to analyze the incidence and spectrum of adverse effects of blood transfusion so as to initiate measures to minimize risks and improve overall transfusion safety in the institute. Materials and Methods: During the period from July 2002 to July 2003 all the adverse events related to transfusion of blood and blood components in various clinical specialties were recorded. They were analyzed and classified on the basis of their clinical features and laboratory tests. Attempt was also made to study the predisposing risk factors. Results: During the study period 56,503 blood and blood components were issued to 29,720 patients. A total of 105 adverse reactions due to transfusion were observed during the study period. A majority of the adverse reactions was observed in hemato-oncology patients 43% (n = 45) and in presensitized patient groups 63% (n = 66). FNHTR 41% (n = 43) and allergic reactions 34% (n = 36) were the most common of all types of adverse transfusion reactions, followed by AcHTR 8.56% (n = 9). Majority of these AcHTR were due to unmonitored storage of blood in the refrigerator of wards resulting in hemolysis due to thermal injury. Less frequently observed reactions were anaphylactoid reactions (n = 4), bacterial sepsis (n = 4), hypervolemia (n = 2), hypocalcemia (n = 2), TRALI (n = 1), DHTR (n = 1), and TAGvHD (n = 1). Conclusion: Analysis of transfusion-related adverse outcomes is essential for improving safety. Factors such as improvement of blood storage conditions outside the blood bank, improvement in cross-matching techniques, careful donor screening, adherence to good manufacturing practices while component preparation, bedside monitoring of transfusion, and documentation of adverse events will help in reducing transfusion-related morbidity and mortality.
Medical Journal of Bakırköy, 2023
Objective: Blood transfusion is a life-saving medical intervention. Transfusion reactions are undesirable consequences of this intervention and may present with various findings. Using data from our hospital and hemovigilance procedures that included electronic recording, our aim was to evaluate non-infectious transfusion reactions. Methods: We present reaction data from electronic recordings of blood products transfused between January 2017 and December 2021. Gender, age, symptoms and findings, blood pressure, fever, respiratory and heart rates before and after transfusion were analyzed according to reaction types. Reactions were classified according to clinicians definition. Analysis of the data was carried out using the SPSS 25 package program. Results: While allergic transfusion reactions and febril nonhemolitic transfusion reactions were common transfusion reactions, the most common reaction products were fresh frozen plasma, erythrocyte suspension and platelet suspension respectively. Chills, restlessness, fever, were common signs and symptoms. While allergic transfusion reactions were higher in pediatric patients, there was no difference between genders. The high number of patients who had a previous transfusion among the patients who developed a reaction suggested that exposure did not reduce the risk. More notifications were made after the use of electronic records than in previous years. Conclusion: Electronically recorded hemovigilance data can contribute to an increase in accurate classification and reporting of transfusion reactions and monitoring of blood processes. Keywords: Transfusion reactions, allergic reactions, febrile reactions, electronic hemovigilance, transfusion related adverse events