Pelagia Research Library Evaluation of anticarcinogenic activity of Clerodendrum serratum leaf extract on liver and kidney of 7, 12-dimethylbenz[a]anthracene (DMBA) induced skin carcinogenesis in mice (original) (raw)
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2013
Investigation of cancer chemopreventive and anti-oxidative property of S.cumini seed extract (SCE) on 7,12-dimethyl benz(a)anthracene (DMBA) induced skin carcinogenesis in mice. Animals were divided into four groups on the basis of their respective treatments wherein mice of Group I & II served as vehicle treated and SCE treated controls respectively. For induction of skin tumors, mice of Group III and IV were applied topically with 7,12-dimethylbenz(a)anthracene (DMBA) followed 2 weeks later by repeated application of croton oil (1% in acetone three times a week) and continued till the end of the experiment (i.e. 16 weeks). Mice of Group IV were administered S.cumini seed extract (SCE) at peri- & post-initiational stage. The results of the study revealed a significant decrease in incidence, cumulative number of papillomas, tumor yield and tumor burden in mice of Group IV as compared with DMBA alone at the end of experiment. A significant reduction in tumor weight and tumor volume w...
Cancer is the second leading cause of death globally. Cassia fistula (CF), a member of Leguminosae family, is Native to India, Amazon and Sri Lanka, is widely used for its medicinal properties in Indian system of medicine for various ailment from the ancient time. The present investigation was undertaken to investigate the anticarcinogenic action of Cassia fistula L. extract on 2-stage skin carcinogenesis model in Swiss albino mice. The papilloma were produced on mice skin by DMBA and promoted by croton oil and one weeks later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks). After 16 weeks at the time of termination of the experiment estimation of GSH from the liver and blood tissue of the animals were also done by the method of Beutler et. al. (1963). the outcomes of the papilloma study and GSH estimation was correlated and it was found to be preventive for the formation as well as persistence of papilloma. 21 no. of papilloma were found in CF treated mice as compared to (35) untreated control mice. Our results suggest that Cassia fistula can be a cost effective future herbal alternative medicine for cancer treatment.
Asian Pacific journal of cancer prevention : APJCP
We report the chemopreventive activity of Acacia nilotica (Linn.) gum, flower and leaf aqueous extracts, on 7,12-dimethylbenz(a)anthracene (DMBA) induced skin papillomagenesis in male Swiss albino mice. Animals were divided into following groups: Group I (Controls) given DMBA and croton oil, with no extract ; Group II (treatment) animals treated with Acacia nilotica gum (Group II-a) (800 mg/kg body weight), flowers (Group II-b) (800 mg/kg body weight), or leaves (Group II-c) (800 mg/kg body weight) during the peri- and post initiation periods of DMBA and croton oil application. A significant reduction in the values of tumor burden, tumor incidence and cumulative number of papillomas was observed in mice treated by oral gavage with the Acacia nilotica gum, flower and leaf extracts as compared with the control group. The latency period in treatment Group-II (b) and Group-II (c) was significantly increased as compared with the control group. A significant reduction in the frequency of ...
Anticarcinogenic effects of an aqueous infusion of cloves on skin carcinogenesis
Asian Pacific journal of cancer prevention : APJCP, 2005
Spices and flavouring agents are now receiving increasing attention as many of them have been shown to have anticarcinogenic properties. Cloves, sun-dried unopened flower buds from the plant Syzygium aromaticum L, are commonly used as a spice and food flavour. The present study was designed to investigate the chemopreventive action of aqueous infusion of cloves on 9,10-dimethyl benz(a)anthracene (DMBA) and croton oil induced skin carcinogenesis in Swiss mice. The results indicate protection against skin papilloma formation in a dose dependent manner. It has been shown that oral administration of aqueous infusions of clove at a dose of 100 microl/mouse/day not only delays the formation of papilloma but also reduces the incidence of papilloma as well as the cumulative number of papillomas per papilloma bearing mouse. Our observations suggest a promising role for cloves in restriction of the carcinogenesis process.
Integrative Cancer Therapies, 2010
The inhibition of tumor incidence by hydro-alcoholic extract of S.cumini seed was evaluated in mice on two stage process of skin carcinogenesis induced by single application of 7, 12-dimethyl benz(a)anthracene (100 µg/100µl of acetone), and 2 weeks later promoted by repeated application of croton oil (1% acetone/thrice in a week) till the end of the experiment (i.e. 16 weeks). Oral administration of extract at a dose of 250mg/kg b.wt./day at the peri-initiational stage (i.e. 7 days before and 7 days after DMBA application), promotional stage (i.e. from the time of croton oil application) and at both the stages (i.e. 7 days prior to DMBA application & continued till the end of experiment) to the mice, recorded a significant reduction in tumor incidence to 37.5, 50 & 25% respectively in comparison to the carcinogen treated control, where tumor incidence was found as 100%. Tumor yield and Tumor burden were also significantly reduced by SCE. Similarly, the cumulative number of papilloma...