Prevalence of metabolic syndrome among psoriatic patients attending a tertiary care hospital in Western India (original) (raw)
Related papers
International Journal of Research in Dermatology
Background: Psoriasis is a chronic inflammatory skin disease that affects 1-3% of the population. Recent studies have reported that psoriasis is associated with metabolic disorders, including obesity, dyslipidaemia and diabetes. The aim of the present study was to investigate the prevalence of metabolic syndrome (MS) in psoriasis and to evaluate the association with severity and duration of psoriasisMethods: This was a hospital based cross sectional study that involved 60 patients with psoriasis evaluated for MS. Statistical analysis was done by SPSS version 16.0 software. Percentages, mean, standard deviation, correlation, chi-square test, t test were calculated at 5% level of significance.Results: 20% of patients had MS which is comparable to the normal population. 60% of the patients in our study are obese which is directly correlating with MS. There is significant increase in MS as age (p =0.01), duration of psoriasis (p =0.03), BMI (p =0.0001), waist circumference (p =0.0001) i...
https://www.ijhsr.org/IJHSR\_Vol.7\_Issue.10\_Oct2017/IJHSR\_Abstract.03.html, 2017
Background: Psoriasis is a chronic inflammatory and proliferative condition of the skin, characterized by scaly, sharply demarcated, indurated plaques, present particularly over extensor surfaces and scalp. Metabolic syndrome is a cluster of risk factors including central obesity, dyslipidemia, hypertension and glucose intolerance, and is a strong predictor of cardiovascular diseases, diabetes and stroke. Recent studies have shown that the prevalence of metabolic syndrome in psoriasis is significantly elevated. Aim: To evaluate the prevalence of metabolic syndrome among newly diagnosed psoriasis patients. Methods: The study comprised sixty new cases of psoriasis patients attending the outpatient of Department of Dermatology and Venereology from June 2012 to May 2013 and sixty healthy individuals as controls. Venous samples were taken at the first visit after the subjects had fasted overnight (at least 8 hours). Plasma glucose and lipid profile were estimated. Waist circumference and blood pressure were recorded. Participants with 3 or more criteria were defined as having metabolic syndrome according to South Asian Modified National Cholesterol Education Program Adult Treatment Panel III. Results: In the psoriasis group, 16(26.66%) patients had metabolic syndrome, where as in the control group only 5 (8.33%) had metabolic syndrome, which showed a significant association with P= 0.016. Conclusion: There was a significantly higher prevalence of metabolic syndrome in patients with psoriasis, which could play a relevant role in accelerating atherosclerosis. The association was not limited to severe cases but also occurs with mild cases. Therefore, the study emphasized the fact that for the better management and to prevent the future risk of cardiovascular complications, all patients must be screened for cardiovascular risk factors at the disease onset, irrespective of the severity of psoriasis. All patients with psoriasis should be encouraged to correct aggressively their modifiable cardiovascular risk factors.
Metabolic Syndrome in psoriasis: a hospital based cross-sectional study in Central India
International Journal of Medical Research and Review
Background: Psoriasis is a chronic immune-mediated inflammatory disorder, reported to be associated with obesity, dyslipidaemia and diabetes via common immunological mechanisms. All of these components ultimately increase the risk of metabolic syndrome and cardiovascular morbidities. Aims and Objectives: To assess the association of Metabolic Syndrome (MS) and its components in patients suffering from psoriasis. To study the relationship between the duration and severity of psoriasis and MS. Materials and Methods: A hospital based cross-sectional study was conducted involving 100 adult patients with psoriasis and 100 controls. All participants were evaluated forpsoriasis and the components of MS. Psoriasis was categorized as mild, moderate and severe based on Psoriasis Area and Severity Index (PASI) (<7, 8-12 and >12, respectively). In all patients and controls, body mass index was calculated, blood pressure and waist circumference were measured and fasting blood sugar and lipid profile were estimated. Results: In the present study, a higher prevalence of MS in Psoriasis patients than in controls (38% v/s 23%) was observed. Psoriatic patients had higher prevalence of hypertension (36% v/s 14%). It can be concluded that association of MS and psoriasis is independent of the type, duration and severity of psoriasis. Conclusion: The present study suggests that subjects with psoriasis present a greater risk of MS and should trigger a higher clinical suspicion for their coexistence. Psoriasis is a systemic disease with significant morbidity and mortality. This study emphasizes the critical need for providers to screen psoriasis patients for early diagnosis and treatment of associated MS. However, more number of large population based cohort studies are required to establish stronger association between psoriasis and MS.
A study on metabolic syndrome in patients with Psoriasis
IP Innovative Publication Pvt.Ltd, 2017
Objectives To study the association of psoriasis and metabolic syndrome. To evaluate the disease activity and duration in psoriatic patients with and without metabolic syndrome. Materials and Method: The study was conducted at MVJ Medical College, Hoskote, Bangalore. 100 newly diagnosed psoriasis patients who had not received systemic treatment 1 month before enrollment were included in study. A complete lipid profile with fasting blood glucose levels were estimated together with measurement of blood pressure and central obesity. Serum lipids were measured and fasting glucose was analysed. Results: Among the 100 patients studied, a majority of patients were male (56%), while female patients accounted for 44%. 37 out of 100 patients had metabolic syndrome. Impaired HDL levels and fasting triglyceride were the most commonly affected components of metabolic syndrome affecting 59% and 54% respectively. There was a direct relationship between the occurrence of metabolic syndrome and extent of body surface area involved by psoriasis. Patients with psoriasis for more than 73 months had a higher occurrence of metabolic syndrome (37.84%). There was no significant correlation between PASI score and metabolic syndrome. Interpretation and conclusion: Our study correlated with the various Indian and western studies proving an association between psoriasis and metabolic syndrome. This has important implication in aiding the dermatologist to tackle issue of metabolic syndrome in psoriatic patients and in the process prevent the cardiovascular complication that are anticipated.
Metabolic syndrome in patients with psoriasis: A comparative study
Indian Dermatology Online Journal, 2014
Background: Psoriasis patients are at increased risk of developing the metabolic syndrome (MS). Proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6 that are increased in the psoriatic plaques are known to contribute to features of MS such as hypertension, dyslipidemia and insulin resistance. Aims: (1) To establish the frequency of MS in patients with psoriasis. (2) To study the risk factors associated with MS in psoriasis. Materials and Methods: A hospital based comparative study was conducted involving 40 adult patients with psoriasis and 40 age-and sex-matched controls. All participants were evaluated for components of MS. Results: Both groups included 31 males and 9 females. The mean age of the cases and controls were 49.95 years and 49.35 years, respectively. Psoriasis patients with MS had a statistically significant higher mean age (56.31 ± 11.36 years) compared with those without MS (46.89 ± 11.51 years). MS was present in 13 out of 40 (32.5%) patients with psoriasis and 12 out of 40 (30%) controls; this difference was not statistically significant. Higher age and female gender correlated with the presence of MS in psoriasis patients. The presence of MS in psoriasis patients was statistically independent of psoriasis area severity index score, body surface area involvement or psoriatic arthropathy. Conclusion: Our results suggest that there is no close correlation between psoriasis and MS in South Indian patients.
A Case Control Study of Metabolic Syndrome in Psoriasis Vulgaris Patients at Tertiary Care Institute
MVP Journal of Medical Sciences, 2016
Background: Psoriasis is a chronic, disfiguring, inflammatory and proliferative condition of skin influenced by both genetic and environmental factors. The prevalence of psoriasis vary from 0.1% to 3% in different population1. The pathogenesis of psoriasis is interplay of various inflammatory cytokines and chemokines which play an important role in the pathogenesis of various other systemic diseases. Psoriasis has been reported to be associated with metabolic syndrome which increases the risk of Coronary Artery Disease. Aim: To study the prevalence of metabolic syndrome among patients of psoriasis vulgaris. Setting and Study Design: This is a case-control study and was conducted at the out-patient clinic of Department of Dermatology, Venereology and Leprology of a tertiary care centre. Materials and Methods: Study was approved by the Institutional ethical committee. The patients were included in two study groups. 50 patients diagnosed with psoriasis vulgaris were included as cases. ...
Journal of Nepal Medical Association
Introduction: Metabolic syndrome, a constellation of features such as obesity, hypertension, dyslipidemia and insulin resistance is of common occurrence in patients with psoriasis. Systemic inflammation is supposed to play a significant role in both conditions. The co-occurrence of metabolic syndrome and psoriasis can result in clinical consequences. The aim of this study was to find out the prevalence of metabolic syndrome among patients with psoriasis attending the Outpatient Department of Dermatology, Venereology and Leprology in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted in the Outpatient Department of Dermatology, Venereology and Leprology from 4 July 2022 to 4 May 2023. The ethical approval was obtained from Institutional Review Committee (Reference number: CMC-IRC/078/079-300). Patients aged more than 18 years diagnosed with psoriasis who provided written consent were enrolled in the study. Pregnant female patients and those who did not...
Frequency of metabolic syndrome in patients of psoriasis
Journal of Pakistan Association of Dermatology, 2018
Objective To find the frequency of metabolic syndrome in patients of psoriasis. Methods It was an observational study carried out in a tertiary care hospital in Lahore, Pakistan. A total of 100 patients diagnosed as psoriasis both clinically and where needed supplemented by histopathology, were included in the study using non-probability purposive sampling technique. Patients’ data including their body mass index (BMI), waist circumference, systolic and diastolic blood pressure (BP), fasting blood sugar (BSF), fasting triglycerides (FTg) and fasting high density lipoproteins (FHDL) were recorded. Patients were categorized as having metabolic syndrome if their waist circumference was >40cm for males and >35cm for females or their BMI was >30kg/m 2 plus they had any two abnormalities among hypertension, raised fasting plasma triglycerides, reduced HDL and raised fasting blood sugar level. Results There were 73 males and 27 females. Metabolic syndrome was identified in 41 (30 ...
International Journal of Research in Dermatology, 2021
Background: Psoriasis is an immune mediated chronic inflammatory dermatosis and it is associated with high risk of cardiovascular events. Aim of the study was to estimate the prevalence of metabolic syndrome and its association with disease severity in patients with psoriasis.Methods: This was a case control study which included 150 cases of chronic plaque psoriasis and 150 healthy controls. All subjects underwent detailed history and clinical examination including measurement of blood pressure and waist circumference and psoriasis area and severity index (PASI) score. Fasting blood sugar, triglyceride, cholesterol, and high-density lipoprotein cholesterol levels were tested following overnight fasting. Various parameters of metabolic syndrome were compared in two groups using chi square test and fisher’s exact test. Statistical analysis of the data was done using epi-info TM software.Results: Prevalence of metabolic syndrome was more common in patients of psoriasis than in control ...