Vitamin D binding protein is lower in infertile patients compared to fertile controls: a case control study (original) (raw)
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Nutrients
Background: Infertility and fecundability problems have been linked with lower 25-hydroxyvitamin D (25(OH)D) concentrations, but studies conducted with small, heterogenous or selected populations have shown inconsistent results. Methods: This study included women at age 31 from prospective population-based Northern Finland Birth Cohort 1966. Serum 25(OH)D concentrations were evaluated between women with or without previous infertility examinations or treatments (infertility group, n = 375, reference group, n = 2051) and time to pregnancy (TTP) of over 12 months (decreased fecundability group, n = 338) with a wide range of confounders. Furthermore, 25(OH)D concentrations were also compared among reproductive outcomes. Results: The mean 25(OH)D concentration was lower and 25(OH)D < 30 nmol/L was more frequent in women with a history of infertility compared to reference group. Moreover, 25(OH)D > 75 nmol/L was more frequent in the reference group. The mean 25(OH)D concentration w...
IMPLICATIONS OF SERUM VITAMIN D LEVELS IN FEMALE INFERTILITY: A REVIEW (Atena Editora)
IMPLICATIONS OF SERUM VITAMIN D LEVELS IN FEMALE INFERTILITY: A REVIEW (Atena Editora), 2022
Vitamin D is a fat-soluble vitamin with several physiological functions and has been related as a possible factor of influence on the reproductive process and, especially, on the female reproductive physiology. However, despite the increasing number of studies in the area, its influence on reproductive health has not been clarified, with conflicting results in responding if there is an association between low serum vitamin D levels and female infertility. The aim of this review is to elucidate the effect of vitamin D on female infertility, presenting current evidence of the association of serum levels of vitamin D in the face of several causes of infertility. A bibliographic search was performed in the MEDLINE (Pubmed), Google Academics, Scielo, Cochrane Central, Research Gate and Public Domain databases, using the word combinations: “vitamin D intertility”, “vitamina D infertilidade”, “vitamin d infertility polycystic ovary syndrome”. The selected articles were from January 2018 to April 2019. Selected studies show that low vitamin D levels are associated with impaired fertility in women diagnosed with endometriosis and polycystic ovarian syndrome, as well as an association with successful in vitro fertilization. However, although there are suggestions and physiological evidence to support a relation of vitamin D deficiency and infertility, randomized controlled trials are still required in different populations to confirm that variations ins serum vitamin D concentrations compromises the health and fertility of women. Determination of serum vitamin D concentration in the reproductive period and the vitamin D supplementation would have important implications for the public health of different communities.
Vitamin D deficiency and infertility: insights from in vitro fertilization cycles
Context: Vitamin D deficiency has been proven to affect fertility in mammals but data in human is less convincing. In particular, data on in vitro fertilisation (IVF), an attractive model to draw information on this topic, are sparse and conflicting. Objective: To investigate IVF outcome in women with deficient 25-hydroxy-vitamin D [25(OH)D] serum levels (<20 ng/ml). Design: Prospective cross-sectional study. Setting: Infertility Unit of an academic setting. Patients: The main inclusion criteria were as follows: 1) indication to IVF, 2) age 18-42 years, 3) BMI 18-25 Kg/m 2 , 4) adequate ovarian reserve according to Bologna criteria. Eligible women provided a serum sample for 25(OH)D measurement at the time of cycle preparation. Subjects were subsequently excluded if the cycle was cancelled or if the attempt was excessively delayed. Intervention: Quantitative detection of serum 25(OH)D. Main outcome measure: Clinical pregnancy rate. Results: The number of recruited women with serum 25(OH)D <20 ng/ml and ≥20 ng/ml was 154 and 181, respectively. The clinical pregnancy rates were 20% (30/154) and 31% (56/181), respectively (p=0.02); the adjusted Odds Ratio for clinical pregnancy in women with vitamin D ≥20 ng/ml was 2.15 (95%CI: 1.23-3.77). Subgroup analyses showed that the group of women with the highest serum levels (>30 ng/ml) had the highest chances of pregnancy. Conclusions: Vitamin D is an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.
High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
Nutrients, 2015
A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associat...
Archives of Medical Science
IntroductionFollicular and serum vitamin D are considered potential markers of the oocyte and embryos' quality and predictors of IVF outcomes.Material and methodsThis retrospective cross-sectional study correlated vitamin D in sera and follicular fluid of women with unexplained infertility mutually and with IVF outcomes. ELISA was used for measuring Vitamin D.ResultsResults show only a positive correlation between follicular and serum levels of Vitamin D (Rho=0.615, p=0.025) and between follicular levels of Vitamin D with the percentage of embryo fragmentation (Rho=0.544; p=0.036).ConclusionsResults suggests that serum and follicular fluid vitamin D measurements could be complementary tools to the routine assessment of embryos.
Fertility and sterility, 2017
To evaluate the role of vitamin D intake and serum levels on conception of clinical pregnancy and live birth. Prospective cohort study. Academic medical centers. Healthy, nulliparous women, age 18-39 years, and their male partners. None. Clinical pregnancy and live birth were compared between those who did or did not meet the vitamin D estimated average requirement (EAR) intake (10 μg/d) and with serum 25-hydroxyvitamin D (25(OH)D) considered at risk for inadequacy or deficiency (<50 nmol/L) or sufficient (≥50 nmol/L). Among 132 women, 37.1% did not meet the vitamin D EAR and 13.9% had serum levels at risk for inadequacy or deficiency. Clinical pregnancies were significantly higher among women who met the vitamin D EAR (67.5% vs. 49.0%) and with sufficient serum 25(OH)D (64.3% vs. 38.9%) compared with those who did not. Live births were higher among those who met the vitamin D EAR (59.0% vs. 40.0%). The adjusted odds ratio (AOR) of conceiving a clinical pregnancy was significantl...
Vitamin D and Vitamin D Receptor in Female Infertility
Journal of Aziz Fatimah Medical & Dental College, 2021
Objective: To investigate the possible association of serum and follicular fluids(FF) Vitamin D levels with reproductive outcomes after assisted reproductive techniques (ART). Secondly, to detect Vitamin D Receptors (VDR) in serum and follicular fluid (FF) of ovarian follicle and explore its relationship with Vitamin D levels as well as reproductive outcomes. Methodology: This study was conducted on May 2019 in Aga Khan Hospital, Karachi, Pakistan. A total of 8 infertile female subjects were conveniently recruited. Serum was collected and follicular fluid(FF) was obtained by transvaginal-guided follicular puncture; 34 hours after intramuscular administration of Human Chorionic Gonadotrophin (HCG). Vitamin D and VDR was assessed in serum as well as in FF by Paired Sample t-test. Results: Females 2 out of 8 acquired clinical pregnancy, whereas 3 had pre-clinical abortion or no pregnancy. Vitamin D and VDR were detected highest in those female patients that acquired pregnancy in compar...
The role of vitamin D in impaired fertility treatment
Neuro endocrinology letters, 2013
Vitamin D is currently in the scope of research in many fields of medicine. Despite that its influence on health remains uncertain. This paper presents the review of the publications concerning the role of calciferol in reproduction processes and its significance in infertility therapy covering topics of polycystic ovary syndrome, endometriosis infertility, myoma infertility, male infertility, premature ovary failure and in vitro fertilization techniques. The results of latest research articles in those fields has been discussed and summarized. The deficiency of vitamin defined as the concentration of 25-hydroxycalciferol <20 ng/ml is frequently noted in patients of fertility clinics. Serum vitamin D concentration in healthy women is higher comparing to PCOS patients. The supplementation with vitamin D should be applied in the schemes of PCOS treatment both due to an improved insulin resistance and the results of infertility treatment. The explanation of vitamin D activity mechan...
Journal of Human Reproductive Sciences
Context: Human and animal data suggest that low vitamin D (25-hydroxyvitamin D) status is associated with impaired fertility, endometriosis, and polycystic ovary syndrome. Vitamin D regulates antimullerian hormone (AMH), FSH, mRNA, and expression of genes in reproductive tissues, implicating a role in female reproduction. Aims: To study the vitamin D levels in infertile females and to know the correlation of vitamin D deficiency (VDD) with serum AMH in infertile females compare to fertile females. Settings And Design: This prospective study was conducted in department of Maternal and Reproductive Health in between April 2014 and April 2016. Materials and Methods: After matching inclusion and exclusion criteria out of total 70 infertile females, 45 were found to have VDD. Of these 35 patients were identified as cases; in whom, the AMH levels were assessed. As control 35 fertile normal females were taken, in which vitamin D and AMH were taken. In both groups, correlation of VDD with AMH was studied. Statistical Analysis Used: To analyze the correlation between vitamin D and AMH linear regression test and for comparison of both the groups, two sample t tests were used. Results: The VDD was present in 64.28% of infertile females. In vitamin D deficient cases, the mean for vitamin D was 6.18 ± 2.09 and AMH was 1.94 ± 1.30. In vitamin D deficient controls, the mean for vitamin D was 4.85 ± 3.02 and AMH was 3.47 ± 2.59. On comparison, the vitamin D levels were lower in fertile than infertile females, which was significant (P = 0.04), and AMH levels were lower in cases than control group (P = 0.003). Conclusion: The VDD was present in 64.28% of infertile females. No significant correlation was found in between VDD and AMH levels in both the groups.
The effect of serum vitamin D levels on ovarian reserve markers: a prospective cross-sectional study
Human Reproduction, 2016
Is there any association between serum 25-OH vitamin D levels and ovarian reserve markers in infertile women? SUMMARY ANSWER: Vitamin D is not associated with the ovarian reserve markers, anti-mullerian hormone (AMH) and antral follicle count (AFC), in infertile women. WHAT IS KNOWN ALREADY: The mechanism underlying the relationship between vitamin D deficiency and reproduction is still unclear; however, evidence indicates a potential direct negative impact on ovarian function. This is mainly due to the fact that gonadal function may be altered by vitamin D deficiency, as observed by the expression of vitamin D receptor mRNA in human ovaries, mixed ovarian cell cultures and granulosa cell cultures. On the other hand, results from clinical studies are conflicting, with some suggesting that vitamin D status is associated with ovarian reserve, whereas other cross-sectional studies have not found any significant correlation between vitamin D and AMH levels. STUDY DESIGN, SIZE, DURATION: This study was a prospective cross-sectional study from the Centre for Reproductive Medicine at the University Hospital of Brussels. The duration of the study was one year. PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, the study included 283 consecutive infertile women younger than 42 years old and undergoing their first treatment cycle in our institution. All patients were recruited within a time interval of 12 months from the initiation of the study, before undergoing infertility treatment. Women consuming vitamin D supplements or taking medication for systematic disease or women who had undergone ovarian surgery were excluded from the study. All infertile women had serum AMH and vitamin D sampled on the same day. AFC was measured on the second or third day of the first cycle following the blood sampling for the determination of AMH and 25-OH vitamin D levels. MAIN RESULTS AND THE ROLE OF CHANCE: Among all patients, 30.7% (n = 87) were vitamin D deficient (<20 ng/mL) whereas 69.3% (n = 196) had normal vitamin D levels (≥20 ng/mL). The mean AMH and AFC levels did not differ significantly between the two groups: AMH 3.9 μ/L (±3.8) versus 4.3 μ/L (±4.8), (P value = 0.5) and AFC 13.9 (±13.3) versus 12.7 (±11.4), (P = 0.7), respectively. No correlation was observed between 25-O H vitamin D and AMH (spearman's r = 0.02, P value = 0.7) or AFC (spearman's r = −0.02, P value = 0.7). In multiple linear regression analysis, after adjusting for potential confounders (age, BMI, smoking status, infertility cause and season of blood sampling), the regression slope in all participants for total 25OH-D predicting log 10 AMH was 0.006 [standard error (SE) = 0.07, P value = 0.9]. Similarly, no significant association was observed between AFC and vitamin D levels, even after controlling for relevant co-variants (regression coefficient −0.09. SE 0.08, P value = 0.2). WIDER IMPLICATIONS OF THE FINDINGS: Although data from basic research indicate that vitamin D deficiency may have an effect on steroidogenesis and follicular development, our study, by prospectively recruiting a large number of infertile women, clearly demonstrates that vitamin D deficiency is highly unlikely to have a detrimental effect on ovarian reserve. Ongoing prospective and translational research projects are currently being conducted in order to evaluate the potential effect of vitamin D deficiency on reproductive outcome mediated through either an effect on the oocyte quality or on endometrial receptivity and embryo implantation.