A Historical Tale of Two Lymphomas: Part II: Non-Hodgkin lymphoma (original) (raw)
Related papers
Non-hodgkin's lymphoma.A study of the evolution of the disease based upon 92 autopsied cases
Cancer, 1979
The evolution of the disease process in 92 patients with non-Hodgkin's lymphoma has been analyzed by comparing the initial histopathologic material with that obtained at autopsy. The distribution of lymphoma did nat differ substantially among the subtypes, but the gross appearance of the lesions was different among certain subtypes, particularly between the "small cell" and "large cell" types. The diffuse lymphomas showed a remarkable constancy of subtype in the same patient, whereas the nodular lymphomas showed a high frequency of change to a diffuse pattern and/or a larger cell type. Diffuse histiocytic lymphomas with plasmacytoid features showed a striking propensity for involvement of the gastrointestinal tract. The Occurrence and significance of bizarre pleomorphic giant cells, epithelioid histiocytes, a "starry-sky" pattern, erythrophagocytosis, hemosiderosis and extramedullary hematopoiesis are reported. All patients received anti-lymphomatous chemotherapy and/or radiotherapy. A second malignancy was observed in 8 patients. Thirteen patients showed no residual lymphoma at autopsy. The cause of death was considered to be related to lymphoma in all 92 patients; 67 had infections identified. Cancer 44:529-542, 1979. HE EXTENSIVE pretreatment evaluation of T large numbers of patients with non-Hodgkin's lymphomas has substantially increased our knowledge of these diseases.8*16 Previous reports have confirmed the usefulness of the classification of Rappaport by demonstrating correlations between histologic subtype and age, stage and p r o g n~s i s. '~~'~ The architectural pattern and cytologic type have usually been constant in multiple biopsies from the same patient.20 Whereas early reports often referred to a u t o p~i e s , '~~~~~~~ most recent reports have focused upon the initial biopsy material and have not considered changes in architectural pattern and/or cell type as a function of time and treatment. This
Tumeur évoluée du tronc d’origine lymphomateuse
The Pan African Medical Journal, 2018
Les lymphomes malins constituent un groupe de cancers du tissu lymphoide, ganglionnaire ou extra ganglionnaire, lies a la transformation neoplasique d'une cellule lymphocytaire. On distingue dans cette categorie les lymphomes malins non hodgkiniens. Nous rapportons le cas d'une localisation cutanee evoluee et extremement agressive d'un lymphome malin non hodgkinien diffus. Il s'agit d'un patient âge de 30 ans, marie et pere d'un enfant, chauffeur de profession, suivi en hemato-oncologie depuis 2 ans pour lymphome malin non hodgkinien diagnostique devant des poly adenopathies axillaires et inguinales, ayant beneficie de 13 seances de chimiotherapie. Le patient a ete admis au service de chirurgie plastique, reparatrice, esthetique et des brules du CHU Mohammed VI de Marrakech, pour prise en charge d'une localisation cutanee de son lymphome sous la forme d'une tumeur evoluee de la region latero-thoracique gauche augmentant rapidement de taille. A l'e...
Lymphomas: complexity, not chaos
Current Opinion in Oncology, 2000
Albert Einstein said that in explaining phenomena, things should be made as simple as possible but not simpler. For many years, lymphoma classifications oversimplified the true complexity of this group of tumors. The Working Formulation was designed to be able to include all lymphoid tumors. It was apparent from the outset that a number of the categories could include heterogeneous kinds of tumors that were probably not the same, despite sharing a common name. The Kiel Classification also contained errors (eg, naming a B-cell tumor derived from non-germinal center B cells "centrocytic lymphoma" and others). Both of these schemes, which dominated the field for 15 years, and those that went before them (Rappaport, World Health Organization [WHO], Lukes-Collins, etc.) relied entirely on the histologic appearance of tumors stained with hematoxylin and eosin.
Clinical Manifestations and Natural History of Hodgkin's Lymphoma
Hodgkin's lymphoma usually presents with typical lymphadenopathy that has been detected either incidentally by the patient or by imaging procedures performed for assessment of other conditions. Occasionally, it may be detected when investigation of nonspecific symptoms, such as fever, fatigue, or unexplained pain prompt assessment that, in turn reveals a mass lesion. The diagnosis must be confirmed with an appropriate biopsy. Nowadays, clinicians usually have little difficulty making the diagnosis of Hodgkin's lymphoma. Knowledge of the usual pattern of spread of this lymphoma, with its orderly progression through lymph node groups and its typical forms of extranodal involvement, facilitates timely diagnosis, staging, and treatment planning. Rare manifestations due to involvement of unusual sites or presentation with paraneoplastic organ dysfunction can prove challenging but a search for mass lesions and an appreciation of these uncommonly encountered findings as potential clues to the presence of Hodgkin's lymphoma usually prompts appropriate investigation and correct diagnosis. Finally, an understanding of the usual pattern and timing of relapse and knowledge of the typical types of late toxicity expected after successful eradication of the lymphoma allow the patient's physicians to detect recurrence in a timely fashion and to identify or prevent secondary complications enabling appropriate management plans to be developed.
journal of medical science and clinical research, 2017
Context: Diagnosis of lymphoma constitutes a difficult task in context to subtyping. Accurate diagnosis is essential because the treatment options, responses to therapy and prognosis vary widely depending on the diagnosis. However to make a definitive diagnosis of a lymphoma based solely on the H & E light microscopy, findings may be exceedingly difficult because of frequent absence of distinguishing features. IHC represents a tool that can provide a clear distinction among the different types of lymphoma. The purpose of IHC is to categorize the patient in order to ensure appropriate and specific treatment, as well as to identify tumours at higher risk of recurrence and fatal outcomes. Aims: To study histomorphology of different lymphomas and correlation of it with immunohistochemical findings. Settings and Design: The present study is a retrospective as well as prospective study of lymphoma cases diagnosed based on routine histopathology as well as correlation of it with immunohistochemistry in surgical pathology section of the Central Diagnostic Laboratory, Shree Krishna Hospital, Karamsad from September 2010 to August 2015. Materials and Methods: A detail clinical history, nature of specimen and other investigations were noted in the proforma. Macroscopic and microscopic findings or any incidental findings were documented in the final report. Results: Total 47 cases of lymphoma were diagnosed in study period among them 42 cases were of B cell lymphoma and 7 cases were of T cell lymphoma. All B cell lymphoma were positive immunihistochemically for CD 20 and LCA. Out of 47 cases 25(53.19%) were of lymphoid origin and 22(46.81%) were of extralymphoid site. Conclusion: From this study it was concluded that: In all the cases diagnosis of hematoxyllin and eosin stained sections were correlated with immunohistochemical findings Non Hodgkin's Lymphoma were most common than Hodgkin's lymphoma Lymphnodes are the most common site of origin.