Oral Manifestations Associated to Paracoccidioidomicosis and Histoplasmosis (original) (raw)
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Paracoccidioidomycosis: a series of 66 patients with oral lesions from an endemic area
Mycoses, 2011
America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature. To provide useful information concerning the diagnosis and management of the disease, this study describes demographic and clinical data from the medical records of a consecutive series of 66 Brazilian patients from an endemic area, evaluated in a referral centre for oral diagnosis. In this sample of patients, there was a predominance of middle-aged male patients, who were primarily rural workers. Chronic multifocal disease was prevalent, with lesions also detected in the lungs, lymph nodes, skin or adrenal glands. Most of the cases presented with lesions at the gingival mucosa followed by the palate and lips; these conditions occurring in the oral cavity were frequently associated with pain. Importantly, most of the patients sought professional care for oral lesions. The diagnosis was obtained through exfoliative cytology and ⁄ or biopsy of the oral lesions. Medical treatment was effective, and there were no mortalities in the sample. The present findings not only confirm the importance of oral lesions in the diagnosis and management of PCM but also illustrate that questions still remain unclear, such as the possibility of direct inoculation of the fungus onto oral tissues.
Mycoses, 2003
The present study describes 21 Argentinian patients living in the province of Corrientes, who had developed oral manifestations due to Paracoccidioides brasiliensis infection. Of these, 20 patients were men and one a woman. Patients were of an average age of 39 years (range 25 to 72 years). Approximately, 76.2% of the patients were farmers. Gingival lesions were observed in 76%. Also, the tongue (71%) and the lips (62%) were frequently affected. Cytological smears and histopathology showed the characteristic fungal cells with the characteristic granulomatous inflammatory reaction consisting of lymphocytes, epithelioid cells and giant cells of the Langhans type. All patients except one had detectable pulmonary involvement. Therapy consists of long-term administration of itraconazole. Oral manifestations of paracoccidioidomycosis are characteristic in their clinical presentation. Early diagnosis and adequate therapy may prevent extensive tissue destructions. Long-term follow-up is mandatory.
Rare mycoses of the oral cavity: a literature epidemiologic review
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2009
Stomatologic fungal infections display different etiologies, pathogenesis, and clinical presentations. The incidence of rare mycoses of oral cavity is very low. These infections can involve both immunocompromised and immmunocompetent patients with common predisposing factors, such as diabetes or suffering from diseases causing immune system impairment. Oral mycoses can cause acute, chronic, and mucocutaneous lesions. Candidiasis is the most common mouth mycosis. Although occasionally primary mouth pathogens, Cryptococcus spp. or filamentous fungi (Aspergillus spp. and zygomycetes) can cause oral mycoses, with the oral localization more commonly secondary to a more serious systemic infection. The diagnosis of oral mycoses is based on clinical examination; for yeasts, culture is necessary to identify the etiologic agents; for filamentous fungi, in particular for zygomycetes and dimorphic, a definitive diagnosis can be made by histologic examination and pertinent stains with or without isolation of the fungus from the same site.
Gingival Involvement in Oral Paracoccidioidomycosis
Journal of Periodontology, 2007
Background: Paracoccidioidomycosis, a deep mycosis endemic in parts of Latin America, often presents with oral lesions involving the gingiva. Nevertheless, the periodontal literature is devoid of references to oral paracoccidioidomycosis. The purpose of this study was to characterize the gingival involvement in oral paracoccidioidomycosis and to contrast clinical and histopathologic diagnosis of the disease. Differential diagnosis and management of oral paracoccidioidomycosis were reviewed.
International journal of dermatology, venereology and leprosy sciences, 2022
The oral lesions may be the earliest manifestation of the dermatological diseases or the most significant clinical appearance of some dermatological diseases and occasionally lesions occur simultaneously in the skin as well as mucous membrane. Aims: To study the clinical patterns and frequency of oral lesions. Settings and Design: A descriptive observational study. Methods and Material: It was a hospital based observational study, that was conducted in the department of dermatology of a tertiary care hospital over a period of 24 months. A total number of 100 individuals with oral lesions were included in the study. A detailed history was taken and complete clinical examination was done. Histological and other investigations were done only if essential to establish the diagnosis. Results: In this study, we studied oral lesions in 100 patients, showing female preponderance 53%cases. Most of the patients belonged to 3rd and 4th decade of life 20% and 26% respectively. Among 37 cases of recurrent oral ulcers seen in the study comprised 37.83% cases each of pemphigus group and herpetic stomatitis. The remaining 24.32% were of recurrent aphthae. The 30 cases of oral ulcers seen in the study comprised 33.3% cases, aphthous 30%, neoplastic 23.3%, local trauma 13.3%. The 9 cases of drug induced oral ulcers seen in this study comprised 22.2% each of drug induced cheilitis, SJS, TEN, perioral dermatitis and 11.1% cases of bullous FDE. The 37 cases of oral lesions seen in the study comprised vesiculobullous disorders in 35.13%, reaction pattern in 24.3%, lichen planus in 24.3%, 5.4% each of TEN, SJS, EM and 2.7% of bullous FDE. The 19 cases of infectious etiology leading to oral ulcers comprised of viral infection in 78.9% and fungal infection in 21.1%. The 12 cases of neoplasms comprised of benign in 41.6% cases, premalignant in 33.3% cases, and malignant in 25% of cases. In this study, genodermatosis cases were six in our study cases, four of which were of ectodermal dysplasia, one case of Papillon Lefevre syndrome, one case of neurofibromatosis-1. In this study, most common 58% involved sites were the periodontium, gingivae and buccal mucosa combined. Involvement of the lips 22.2% was the next significant site. Tongue, teeth, salivary glands, palate were 8%, 5%, 4%, 3% respectively. Conclusions: This study brings into focus prevalence of various oral manifestations. Thorough knowledge about oral manifestations is essential to arrive at a specific diagnosis which is a mandate for counselling and management.
Frequency of Oral Mycoses in Patients with Chronic Conditions
The aim of the paper is to highlight the clinical changes (mainly mycoses) in the tongue in patients with general conditions as well as the possible etiopathogenic mechanisms and the correlation between them and local and general risk factors. The method is represented by a rigorous study conducted on 500 patients of both genders between 2010 and 2013. General conditions as well as primary or associated lingual lesions were clinically detected in 221 patients. The results indicated a high rate of primary or associated glossitis as well as a significant number of other types of lingual disorders. The data of the study are presented in graphs and tables. The important conclusion of the paper is the high rate of primary or associated fungal glossitis in patients with a history of chronic disease, as well as the existence of comorbidity-related risk factors and aggravating local-regional factors. The rate of occurrence of other types of glossitis is significantly lower. Cuvinte cheie: a...
Single Oral Paracoccidioidomycosis Mimicking Other Lesions: Report of Eight Cases
Mycopathologia, 2012
Paracoccidioidomycosis is a fungal infection caused by Paracoccidioides brasiliensis. It is an endemic disease, representing a serious health problem in Latin American countries. This infection primarily affects the lungs and is acquired by inhalation of the fungus. It can spread to other organs and tissues, mainly the oral cavity affecting more adult men from 30 to 50 years of age. On clinical presentation, several signs associated with impaired general and nutritional conditions can be noted. Oral manifestation is more common in the soft palate, gingiva, lower lip, buccal mucosa, and tongue. The classical clinical presentation is a superficial ulcer with granular appearance and hemorrhagic points. Usually, the oral lesion is extensive and generalized. Although uncommon, when the oral manifestation is single, others lesions, particularly squamous cell carcinoma, must be included in the differential diagnosis. In this article, the authors discuss the unusual presentation of eight cases of single oral paracoccidioidomycosis and its diagnostic importance.
Rare Infections of the Oral Mucosa
Timisoara Medical Journal
(1) Background: Oral mucosal infections are a commonly encountered clinical pathology in patients who consult dentists, mainly for dental diseases. Currently, the involvement of oral and dental infections in cardiovascular and neurological diseases, among others, is widely discussed in the literature. In the present research, we elaborated a comprehensive report on rare oral mucosal infections, including oral syphilis and head and neck tuberculosis. (2) Methods: The research was performed by the authors using three databases (PubMed, Wiley, and ScienceDirect). Scientific articles published from January 2000 to January 2020 were selected and reviewed to assess the epidemiology, symptoms, and diagnosis of oral syphilis and head and neck tuberculosis. (3) Results: Oral syphilis was mainly noticed as ulcers and secondary types of disease. Tuberculosis of the head and neck was most frequently encountered as cervical lymphadenopathy. (4) Conclusions: Rare oral infections diagnosis may be challenging due to their evolving polymorphic clinical appearance and their ability to mimic various diseases in the oral cavity and head and neck area.
Spectrum of Oral Lesions in A Tertiary Care Hospital
Journal of clinical and diagnostic research : JCDR, 2015
The present study was undertaken to study the spectrum and pattern of various oral cavity lesions in a tertiary care hospital in Rohilkhand region of Uttar Pradesh, India. Oral cavity is one of the most common sites for tumour and tumour like lesions especially in males. It has been observed that benign lesions are more common than malignant ones. A retrospective study was carried out in a tertiary care hospital during the period of two years from June 2012 to May 2014. The study included 133 cases of oral cavity lesions. The parameters included in the study were age, gender, site of the lesion and histopathological diagnosis. Special stains and Immunohistochemical markers were applied as and when required. Data collected were analysed. A total of 133 cases were included in the present study. The age ranged from 8 to 80 years. Males were affected more often than females with a Male: Female ratio of 3.3:1. The most common involved site was tongue 39 (29.32%) followed by tonsil in 30 ...
Journal of Chitwan Medical College
Background: Oral mucosal lesions represent a wide range of anomalies and pathologies that could be attributed to different aetiologies. Awareness about them can help in prevention whereas early detection and prompt treatment minimize impairment and ameliorate symptoms. The objective of the present study was to estimate the prevalence of OML in patients, visiting the dental outpatient department of a tertiary care hospital in Chitwan, Nepal. Methods: The present retrospective cross-sectional study was carried out in the department of Oral Pathology of a tertiary care hospital in Chitwan, Nepal from December 2017 to December 2022. The attributes of the study included the details like age and gender, site, and the histopathological diagnosis of the biopsy specimen. The data extracted were tabulated in excel sheets and were analyzed by the statistical package of social sciences (SPSS) software, version 20. Results: In total 138 cases of OML were included in the present study. The study ...