Transport Properties of Aqueous Solutions of (1 R ,2 S )-(−)- and (1 S ,2 R )-(+)-Ephedrine Hydrochloride at Different Temperatures (original) (raw)
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2015
A new, sensitive, accurate, and precise spectrophotometric method for the determination of ephedrine-hydrochloride (ephedrine-HCl) was developed. The method based on charge transfer reaction between ephedrine-HCl and chloranil reagent to form a colored complex absorbs at 387nm. The optimum conditions of charge transfer complex forms were investigated by (1) univariable method, by optimizing the effect of experimental variables (pH, reagent volume, temperature and time), (2) central composite design (CCD) including the effect of three experimental factors (reagent volume, temperature and time). The linearity ranges of ephedrine-HCl are (4-20 & 20-200) µg.mL -1 at 387 nm with molar absorptivity (3.1867 ×10 3 - 1.6941 × 10 3 ) L.mol -1 .cm -1 , Sandell's sensitivity index (0.0633 - 0.1230) μg.cm -2 and detection limit of (0.0098 – 0.0546) µg.mL -1 . The results showed there is no interferences of excipients on the determination of the drug. The proposed method has been successfully...