Causative bacteria and antibiotic resistance in neonatal sepsis (original) (raw)
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Neonatal sepsis: causative bacteria and their resistance to antibiotics
Journal of Ayub Medical College, Abbottabad : JAMC
Neonatal sepsis is one of the major causes of neonatal morbidity and mortality, particularly in developing countries. The objective of this study was to determine the causative bacteria and level of their resistance to commonly used antibiotics. This descriptive study was carried out at Ayub Teaching Hospital, Abbottabad from April 2009 to January 2010. All neonates of either gender admitted in neonatology unit with clinical sepsis and positive blood culture were included in the study. Neonatal period was defined as 28 days of life at term and up to 44 weeks of gestational age in preterm babies. One hundred and thirty neonates of either gender were studied during the period. Blood sample for culture was taken from a peripheral vein or an artery ensuring standard anti-septic measures. BACTEC technique was used for obtaining bacterial growth and drug sensitivity after incubation of 24-48 hours. Second blood culture was also performed in few cases which were not showing improvement aft...
Journal of clinical neonatology, 2012
To study the bacterial pathogens causing neonatal sepsis and their sensitivity pattern so that guidelines can be prepared for empirical antibiotic therapy. We conducted a prospective analysis of all the cases admitted to the neonatal intensive care unit (NICU) of a tertiary care hospital and studied the culture and sensitivity pattern of organisms isolated. The neonates who presented with signs and symptoms of septicemia, with/without pneumonia and/or meningitis were studied and a detailed record of the maturity, age at onset, sex, birth weight (weight on admission for home deliveries), symptoms and signs along with the maternal risk factors was made. The cases with suspect sepsis were screened using various screening markers. Blood culture was done in all the cases, while cerebrospinal fluid was analysed only in those indicated. Sensitivity of the isolated organism was tested by Kirby Bauer disc diffusion techniques and various drug resistance mechanisms were studied. Out of the 19...
Journal of Rawalpindi Medical College, 2021
Objective: To find out the most common organisms involved in neonatal sepsis origination and observe the pattern of antibiotic sensitivity and resistance of bacterial isolates. Materials and Methods: This descriptive cross-sectional study was conducted at the Department of Paediatrics Izzat Ali Shah Hospital, Wah Cantt. Out of 420 patients admitted with sepsis in NICU, 19.5% of patients with positive blood cultures were included in the study. A consecutive, non-probability sampling technique was used. Results: Out of 82 positive blood cultures gram-positive bacteria were observed in 19 patients (23.2%) and gram-negative bacteria were seen in 63 patients (76.8%). The most common gram-negative pathogens isolated were Acinetobacter (29.3%) and Klebsiella (24.4%). Staphylococcus aureus (12.2%) was the commonest gram-positive organism isolated. Gram-negative organisms showed maximum sensitivity to Tigecycline and Colistin and were resistant to Cefixime, Aztreonam, Amoxicillin, and Ceftri...
Journal of Pharmaceutical Research International
Background: The drug resistance and pathogens are different in various Hospitals of any country. Very high resistance pattern is observed nowadays to the frequently used antibiotics. The important observation has been noted that most of the doctors do not obtain blood cultures before start of the antibiotics, which becomes competent source of resistance. For the same purpose, this study has been done to find out the responsible microbes causing ailment and their susceptibility towards antibiotics to plan early and effective management. Materials and Methods: A number of 100 new borns admitted in the NICU CMC Children Hospital Larkana with signs and symptoms of sepsis were included in this research work. The study will help in provision of a comprehensive record on microorganisms causing sepsis in the neonates and their antibiotic sensitivity. The epidemiology and presence of neonatal sepsis in particular area makes it more easy and convenient to implement the rationale of empirical ...
Sensitivity and Resistance of the Microorganisms Responsible for Neonatal Sepsis to Antibiotics
Archives of Clinical Infectious Diseases, 2020
Background: Sepsis is a major neonatal disease that requires appropriate early treatment. Objectives: The current study aimed to determine the resistance and sensitivity to antibiotics in neonates admitted to the neonatal intensive care unit (NICU) due to sepsis. Methods: In this cross-sectional study, 268 neonates with definitive sepsis (positive blood culture with clinical signs of infection) hospitalized during 2009 - 2019 are investigated. Identification of microorganism and antibiogram test were performed according to the standard microbiological method. Antibiotics susceptibility testing was performed by disk diffusion and microdilution method according to Clinical and Laboratory Standards Institute (CLSI) (2013). A researcher-made questionnaire, including characteristics of neonates and types of microorganisms (Gram-positive or negative) in the neonatal ward, as well as sensitivity and resistance to common microorganisms in neonatal sepsis, was used to collect data. Results: ...
THE PROFESSIONAL MEDICAL JOURNAL, 2017
ORIGINAL PROF-3914 ABSTRACT… Introduction: Neonatal sepsis is a systemic condition characterized by bacteremia that occurs in the first month of life. It is a fatal condition and need to be treated promptly. Bacterial isolates include both gram positive and negative bacteria and the cure of condition is highly dependent on antimicrobial drug sensitivity and resistant patterns. It is there for utmost important to known commonly occurring bacteria in neonatal septic states and their drug sensitivity patterns. Objectives: To determine the frequency of the bacterial isolates in blood and their sensitivity patterns to commonly used antibiotics in neonatal sepsis. Setting: Neonatal intensive care unit(NICU), Department of Shifa International Hospital. (SIH), Islamabad. Study Design: Cross sectional. Duration: This study was conducted between 6 1 st June 2013 to 30 th November 2013. Subject and Methods: A total of 180 neonates, admitted in NICU with evidence of clinical sepsis i.e. with signs and symptoms suggestive of septicemia (fever, lethargy, reluctance to feed, seizures, and irritability) were included in this study. The samples for blood cultures were taken. Identification of bacterial isolates was carried out by the standard bacteriological techniques, which include gram staining and bacterial cultures and antimicrobial sensitivity patterns which was performed by modified Kirby and Bauer disc diffuse method as per CLSI (Clinical and Laboratory StandardsInstitute)guidelines.A predesigned Performa was filled. Results: Culture revealed bacterial growth in 7.2% samples. Gram negative organisms were observed in 6.67% and only 1 were gram positive. In this study, 50% and 100% of E-coli were sensitive to ampicillin, meropenem and amikacin, gentamycin respectively. Sixty to 100% of pseudomonas was sensitive to ceftazidime, tazobactum, meropenem and 100% of enterococcus was sensitive to ampicillin and vancomycin. Conclusion: Antimicrobial drug resistance and constantly changing resistance patterns is emerging issues in various groups of infections and septic states, especially for routinely used antibiotics as found in our study. Thus by prescribing rational use of antimicrobial as per bactriogram, It'll be easier totreat sepsis effectively and economically and reduce the mortality and morbidity related to neonatal sepsis.
Journal of clinical and diagnostic research : JCDR, 2013
Neonatal sepsis is one of the most common causes of neonatal mortality and morbidity, particularly in the developing countries. Its causative bacteria and their respective sensitivity patterns are different in each hospital and region. The objective of this study was to determine the causative bacteria and pattern of susceptibility to antibiotics in NICU of a tertiary care centre, which in turn may help in implementation of empirical therapy. This prospective study was carried out at a medical college during the period from 1st April 2011 to 31st March 2013. A total of 364 cases of suspected sepsis were admitted in our NICU during the mentioned period. Out of which, 137 cases were positive for culture. All the neonates of suspected sepsis were screened by using a panel consisting of CRP, ANC, I/T ratio, micro ESR and culture and sensitivity. A total of 137 cultures were found to be positive out of 364 cases. The most common organism isolated was Staphylococcus aureus (37.22%) follow...
Bacteriological Spectrum of Neonatal Sepsis
2015
Background: To determine the spectrum of causative bacteria and their antibiotics sensitivity and resistance patterns in neonatal sepsis. Methods: In this descriptive study 50 newborns having blood culture proven septicemia were included. Neonates delivered at home or other health facility and consent refused by parents / guardian of neonate were excluded. Information regarding the organisms grown on blood culture (done by BACTEC method) was noted along with the sensitivity and resistance patterns ( checked by standard disc diffusion method) of commonly used antibiotics. During analysis, frequencies and percentages for all categorical variables, i.e. organisms grown on blood culture, their antibiotic sensitivity and resistance patterns, gender, birth weight ( low, very low or normal ), gestational age ( pre, post or term), mode of delivery ( vaginal or caesarean section) and age of onset of illness (early or late ), were calculated. Results: A total of 50 newborns with blood culture...
Bacteriological Profile and Antibiotic Susceptibility Pattern of Isolates in Neonatal Sepsis
Pakistan Journal of Health Sciences
Sepsis in newborns is a serious medical condition having a high mortality. Pakistan and other developing countries have a high burden of neonatal sepsis. Objectives: To determine the bacterial spectrum and antibiotic activity pattern in neonatal sepsis. Methods: This retrospective cross-sectional research was performed at the Pediatrics Unit of Ziauddin University Hospital Karachi from 1st June 2022 till 1st December 2022. A total of 120 medical records of neonates admitted with the clinical suspicion of sepsis were reviewed. Non-probability convenience sampling technique was used. Data regarding clinical characteristics of neonates, type of bacteria isolated and antibiotic susceptibility results were recorded. SPSS version 20 was used for statistical analysis. The results were written as frequencies / percentages. Results: Neonatal sepsis was suspected in 120 newborns but blood culture-proven infection was present in 32 (13.3%) neonates with 23(71.8%) having early -onset sepsis. T...