Improved hematocompatibility of the inner surface of capillary PE tubing by microplasma surface modification (original) (raw)

Abstract

A hollow-cathode microplasma modified the lumenal surface of small diameter (0.28 and 0.8 mm) up to 1 meter long polyethylene (PE) tubing. PE glycol was grafted to the lumenal surface using O2 plasma followed by Ar plasma. Feedstock gases and reaction products drift along the tubing which may cause nonuniform treatment. Emitted light from the plasma was fed into a monochromator at various positions to assess uniformity. Effectiveness was evaluated using capillary-rise, which is related to contact angle. Uniformity of the atomic surface composition along the length of the inner surface of the PE tubing was analyzed by XPS and transmission FTIR. To test hematocompatibility, a flow loop circulated heparinized human blood for various times at 37 C. Plasma-treated and untreated tubing were then examined with a scanning SEM to assess the morphology of adhering platelets. By modifying plasma parameters, uniformity along the tubing and proximity to the peristaltic pump can be optimized.

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