Superdisintegrant: crucial elements for mouth dissolving tablets (original) (raw)
Related papers
Natural Superdisintegrants for the Formulation of Orally Disintegrating Tablets
https://www.ijrrjournal.com/IJRR\_Vol.8\_Issue.11\_Nov2021/IJRR-Abstract017.html, 2021
Oral route is the most favoured and preferred route for the administration for most of the dosage forms because it offers so many advantages over other routes of administration. Sometimes the oral route is associated with a problem called dysphagia. This condition can be seen in a population of paediatric, geriatric, patients with neurological problems, bedridden patients and so on. In order to overcome such a problem orodispersible tablets will be a better choice, because it will disintegrate within seconds when comes in contact with saliva. Natural agents offers so many advantages like nontoxic, easy availability, low cost, biocompatible and biodegradable in nature over synthetic agents. This superdisintegrants will cause the increase in drug release and decrease the disintegration time. This natural superdisintegrants will be a good option for the preparation of ODTs.
International Journal of Green Pharmacy, 2008
Objective: In the present study, the effects of a natural superdisintegrant gellan gum, karya synthetic gum superdisintegrants like sodium starch glycolate, crospovidone and combination of natural and synthetic superdisintegrant were compared in the formulations of rizatriptan benzoate oral dispersible tablets. Methods: This oral dispersible tablets were prepared by direct compression method and evaluated for weight variation, hardness, disintegration time, drug content, friability and dissolution. Drug compatibility with excipients was checked by FTIR studies. Stability study of the prepared tablets was done at 40±2°/75%±5% RH for a period of 1 mo. Results: FTIR studies showed that no any chemical interaction between drugs and excipients. The in vitro drug release study revealed that formulation F9 combination of both crospovidone and karya gum was the most successful formulation and disintegrate time within 13 seconds and drug release within 10 min. The drug release from the best formulations followed first-order kinetics, which is concentration-dependent. Short terms stability studies of the tablet for three months showed non-significant drug loss. Conclusion: The formulation containing a combination of natural and synthetic superdisintegrant was found to be the best results. Apart from fulfilling all official and other specifications, the tablets exhibited a higher rate of drug release.
In the present study Oral Disintegrating Tablets (ODT's) of Bambuterol Hydrochloride were prepared using different natural and synthetic superdisintegrant. The natural Superdisintegrants used were Banana powder, Isphagula Husk powder and Pregelatinized starch, Crospovidone and Sodium Starch Glycolate were used as synthetic superdisintegrant. A direct compression technique was used to prepare oral disintegrating tablets containing Bambuterol Hydrochloride as a model drug. The precompression parameters of mixed blend were examined for parameters such as angle of repose, bulk density, tapped density, Carr's index and Hausner's ratio. Tablets were subjected to Post-compression parameters such as weight variation, hardness, thickness, and friability, wetting time, water absorption ratio, in vitro disintegration time, drug content and in vitro dissolution study. FTIR studies revealed that there were no incompatibilities of Superdisintegrants with drug. Among all the formulations, the batch prepared with 4% crospovidone (F5) and the batch prepared with 4% Isphagula Husk powder (F14) shows disintegration time 10 sec and 16 sec respectively. The formulation with crospovidone showed more than 99% drug release in 30 min. It was concluded that tablets prepared by addition of Synthetic superdisintegrant has less disintegration time, more water absorption and drug release.
2016
Mouth dissolving tablets are increasing more conspicu-ousness as a novel medication conveyance framework and develops as one of the prevalent and broadly acknowledged measurement shapes, particularly for pe-diatric patients in light of fragmented advancement of solid and sensory system and if there should be an occurrence of geriatric patients experiencing Parkinson's issue or hand tremors, frames like tablets and cases are presently days confronting the issues like dysphagia, bringing about the high incidence of rebelliousness and making the treatment incapable. From both pharmaceutical commercial enterprises as well as patients since they are advantageous to be fabricated and controlled, free of side impacts, offering quick discharge and improve bioavailability, in order to accomplish better patient compliance. Oral course is the most favored course for organization of different medications since it is viewed as most secure, most helpful and temperate course. As of late analys...
Natural Super-Disintegrant Agents Used in Various Oral Solid Dosage Forms
Journal of Drug Delivery and Therapeutics, 2021
Super-disintegrating agents are one of the ingredients used in pharmaceutical solid dosage forms. These substances play a vital role in formulation design. Natural super-disintegrants have gained more popularity due to their oral bioavailability. It disintegrates the tablets into smaller particles to enhance the dissolution rate. Fast dissolving, chewable tablets, and other orally administered dosage forms consist of super-disintegrating agents which shows rapid and quick action. Natural super disintegrating agents in pharmaceutical dosage forms are very effective due to their ecofriendly nature as well as these are biocompatible and biodegradable. These are abundantly and cheaply available from nature.Today the researchers are focusing on naturally available excipients. Keywords: Natural Superdisintegrants, Disintegration, Bioavailability, Biocompatible, Biodegradable.
2011
The objective of the present investigation was to study the influence of Superdisintegrants like sodium starch glycolate (SSG), croscarmelose sodium (CCS), crospovidone (CP), Physical mixture of Superdisintegrants and Co process superdisintegrants as dissolution enhancer on in-vitro dissolution in a model formulation and their different mode of incorporation like intragranular, extra granular and equal distribution between these two. Among the superdisintegrant croscarmelose sodium showed comparatively faster disintegrations time than sodium starch glycolate and crospovidone.The results indicated that Coprocess superdisintegrant was effective in improving the dissolution of the drugs used in the study and generally intragranular mode of addition seemed to be the best mode of incorporation.
Review on Fast Dissolving Tablets Technology and Superdisintegrants
Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 2019
The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. It has more significance to geriatric, Paediatric, bedridden patients because they have a problem in swallowing and the patient with dysphasia. It is more useful for the traveller and busy patients who don"t have easy access to water. Fast dissolving tablets are prepared by various technologies with the aid of superdisintegrants. Fast dissolving tablets are more reliable than conventional dosage forms like tablets, capsules because of better patient compliance. The advancement in this field allows the development of an economic and better way of disease management with avoidance of several problems related to the other delivery systems.
A Review on: Importance of Superdisintegrants on Immediate Release Tablets
Among the different routes of administration, the oral route of administration continues to be the most preferred route due to various advantages including ease of ingestion, avoidance of pain, versatility and most importantly patient compliance. The different dosage forms include tablets and capsules. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better patient compliance. They are also a tool for expanding markets, extending product life cycles and generating opportunities. Immediate drug release dosage forms disintegrate rapidly after administration with enhanced rate of dissolution. The basic approach used in development tablets is the use of superdisintegrants like Cross linked Polyvinylpyrrolidone or crospovidone (Polyplasdone), Sodium starch glycolate (Primogel, Explotab), carboxymethylcellulose (Croscarmellose) etc. These superdisintegrants provide instantaneous disintegration of tablet after administration in stomach.
DISINTEGRATING AGENTS THE BACKBONE OF MOUTH DISSOLVING TABLETS
Mouth dissolving tablets (MDT) show the quick onset of action and are currently in demand because of several advantages like palatability and a pleasant mouthfeel. MDT can be consumed without water and shows effective action in a few minutes. MDT is advantageous particularly in all groups including pediatric, mentally ill, and geriatric patients who are unable to swallow conventional tablets and capsules. Disintegrants has a significant role in quick disintegration thereby enhancing its efficacy. In presence of super disintegrants, the tablet dissolves within 5-30 seconds range. Disintegrants are classified mainly into three categories natural, synthetic, and coprocessed. Various super disintegrants e.g. croscarmellose sodium, crospovidone, and sodium starch glycolate are added in MDT for faster dissolution. Various superdisintegrants are available in the market like ludiflash, fmelt, cellactose 80, microcelac 100 and avicel DG, etc The review describes the various formulation aspects, techniques developed for MDTs, and super disintegrants used, along with evaluation tests, drugs, marketed formulation, and various excipients used for R&D. Keywords: ODT, Mouth dissolving tablets, flash dose tablets, mouth disintegrating tablets, oral disintegrating tablets, super disintegrants