Photodynamic Therapy, a new approach in the treatment of oral cancer Terapia Fotodinámica, un nuevo acercamiento en el tratamiento del cáncer oral (original) (raw)

Photodynamic therapy, a new approach in the treatment of oral cancer: [review]

Revista De La Universidad Industrial De Santander Salud, 2010

Photodynamic Therapy, a new approach in the treatment of oral cancer Terapia Fotodinámica, un nuevo acercamiento en el tratamiento del cáncer oral RESUMÉN La incidencia del cáncer de cabeza y cuello es aproximadamente 640.000 casos nuevos por año. El cáncer oral representa un tercio de todos los cánceres y es el octavo más diagnosticado en hombres. Los tratamientos más usados para estos tumores son la cirugía, radioterapia, quimioterapia, o una combinación de estas modalidades terapéuticas. Debido al gran deterioro estructural, funcional y estético que causan los tratamientos convencionales, muchos estudios buscan nuevos métodos para remplazar o asistir el tratamiento del cáncer oral. La terapia fotodinámica (PDT) es una nueva modalidad promisoria en el tratamiento del cáncer que apenas está siendo usada clínicamente. Este artículo describe el uso de PDT como una alternativa para el tratamiento del cáncer oral. Salud UIS 2010; 42: 167-174 Palabras clave: Terapia fotodinámica, cáncer oral, tratamiento

PROSPECTS OF APPLICATION OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF ORAL CANCER

International Journal of Current Research , 2019

Surgery, chemotherapy and radiotherapy are the prime treatment options when it comes to treatment of malignant lesions. Photodynamic therapy (PDT) is a new treatment modality against cancer with special emphasis on the physical and biochemical principles. PDT is also known as photoradiation therapy, phototherapy or photochemotherapy. It is been more than 25 yrs since PDT was proposed as a useful tool in oncology. But now it is clinically approved and more widely used. PDT was developed as a therapy for several diseases such as tumor, periodontitis, other oral lesions and premalignant diseases. It is a minimally invasive treatment with great promise in malignant diseases. It is not only well tolerated but also simple and quick to execute. It has proved to show less morbidity and better function; it also shows excellent cosmetic outcome. Soon PDT has the potential to become integrated into the mainstream of cancer treatment.

photodynamic therapy as a treatment option for oral cancer and dysplasia

The challenge in cancer management is to find a balance between the intended therapeutic outcomes whilst preserving and maintaining function and aesthetics. This dilemma initiated ongoing efforts focusing on PDT which is now considered a historical re-utilized technique showing promising results but with many limitations. PDT has emerged as a successful and clinically acceptable therapeutic approach to the management of malignant and benign diseases. It is important to understand that PDT cannot completely replace other treatment modalities but can be used as a useful adjunct or as additional treatment.

Photodynamic Therapy of Head and Neck Cancers

Methods in molecular biology, 2010

Over 1,500 patients have been treated with PDT using Photofrin, HPD, ALA, or Foscan for head and neck cancers. These patients include a mixture of presentations including primary, recurrent, and metastatic lesions. The predominant histology is squamous cell carcinoma, but other histologies treated include mucosal melanoma, Kaposi's sarcoma, adenocarcinoma, metastatic breast carcinoma, and adenoid cystic carcinoma. Several multi-institutional phase II clinical trials evaluating PDT treatment of head and neck cancers have demonstrated the efficacy of this minimally invasive therapy in the treatment of early oropharyngeal primary and recurrent cancers as well as the palliative treatment of refractory head and neck cancers. Patients with early stage cancers or early recurrences in the oral cavity and larynx (Cis, T1, T2) tend to have an excellent response to PDT. Of 518 patients treated with Cis, T1, or T2 cancers of the oral cavity, larynx, pharynx, and nasopharynx, 462 (89.1%) obtained a complete clinical response after one PDT treatment. Laryngeal cancers, comprising 171 patients in this group, obtained a durable complete response rate of 89% with up to a 16-year follow-up. Photodynamic therapy is as effective as conventional therapies for the treatment of early (Cis, T1, T2) squamous cell cancers of the head and neck. It is also a promising therapy to be used in association with surgery to increase tumor-free margins and therefore increase cure rates.

Photodynamic Therapy as a Treatment Option for Oral Cancer and Dysplasia Ra ’ ed

2018

The challenge in cancer management is to find a balance between the intended therapeutic outcomes whilst preserving and maintaining function and aesthetics. This dilemma initiated ongoing efforts focusing on PDT which is now considered a historical re-utilized technique showing promising results but with many limitations. PDT has emerged as a successful and clinically acceptable therapeutic approach to the management of malignant and benign diseases. It is important to understand that PDT cannot completely replace other treatment modalities but can be used as a useful adjunct or as additional treatment.

Advances in photodynamic therapy for the treatment of head and neck cancers

Lasers in Surgery and Medicine, 2006

Photodynamic therapy (PDT) is an FDA-approved minimally invasive medical treatment modality that utilizes light in the presence of oxygen to activate photosensitizing agents that are relatively selectively concentrated in abnormal or neoplastic cells resulting in cell death. At the present time, PDT has been approved for clinical treatment in the United States, European Union, Canada, Russia, and Japan. In the United States, US Food and Drug administration approval has been given for the use of PDT in the treatment of Barrett's esophagus, obstructing esophageal carcinoma and early and obstructing tracheobronchial carcinoma using the photosensitizer Photofrin; actinic keratosis using the photosensitizer Levulan (aminolevulinic acid); and macular degeneration using the photosensitizer BPD. In the EU the above noted indications have also been approved in addition to the treatment of early head and neck cancers and palliative treatment of head and neck cancer using the photosensitizer Foscan; and treatment of basal and squamous cell skin cancers using the photosensitizer Metvix.

Photodynamic Therapy Treatment of Early Oral and Laryngeal Cancers

Photochemistry and Photobiology, 2007

Photodynamic therapy (PDT) is a nonsurgical, minimally invasive treatment that uses a light source to activate lightsensitive drugs or photosensitizers in the treatment of cancer and other diseases. PDT has been successfully employed to treat early carcinomas of the oral cavity and larynx preserving normal tissue and vital functions of speech and swallowing. Two hundred seventy-six patients with early carcinomas of the oral cavity and larynx were treated from 1990 to 2006. Cure rates with a single treatment for early laryngeal and oral cancers were 91% and 94%, respectively. PDT is an effective primary and alternative treatment modality for early oral cavity and laryngeal cancers.

Photodynamic therapy: the imminent milieu for treating oral lesions

Journal of clinical and diagnostic research : JCDR, 2013

Photodynamic therapy (PDT) is used in curative and palliative treatment of head and neck squamous cell carcinoma (HNSCC) and other oral lesions. Oral infections (such as mucosal and endodontic infections, periodontal diseases, caries, and peri-implantitis) are among the specific targets where PDT can be applied Photodynamic therapy (PDT) efficacy depends on the local dose deposited in the lesion as well as oxygen availability in the lesion. Further long-term clinical studies are necessary in establishing a more specific place of the technique in the field of dentistry.

Photodynamic therapy for head and neck cancer

Diagnostic and therapeutic endoscopy, 1996

Photodynamic therapy (PDT) is a recently developed treatment involving the use of a photosensitizer and low power light, usually from a laser, to selectively destroy tumor cells. At present, we perform PDT for head and neck cancer using argon or excimer dye lasers with hematoporphyrin derivative as a photosensitizer. This study attempted to assess the utility and safety of PDT and to investigate the long-term outcome. All 24 patients had squamous cell carcinoma: 15 with laryngeal, 5 with lingual or oral, and 4 with pharyngeal cancer and were treated by PDT. Data were obtained from records from February 1988 through April 1995. After PDT, 12 of 15 laryngeal cancer patients were classified as having a complete remission (CR), as were 2 of the 5 lingual or oral and one of the 4 pharyngeal cancer patients. The patients were followed for 8 to 153 months. The longest duration of CR in patients treated by PDT alone was 148 months. Photosensitivity was experienced by all patients, but requi...