Polymeric Transdermal Drug Delivery System of Ramipril and Repaglinide: In-Vitro and Ex-Vivo Evaluation (original) (raw)

2017

Abstract

The current project was designed with the aim to develop a transdermal drug delivery system in the form of matrix type transdermal patches integrated with Ramipril and Repaglinide. Different formulations were prepared by varying concentrations of HPMCK4M and Eudragit L100 (EL100) by solvent casting method. Oleic acid and Propylene glycol were employed as penetration enhancers and Polyethylene glycol 400 was used as plasticizer. Formulated patches were subjected to various evaluating parameters including pre-formulation studies FTIR, SEM and UV analysis and post formulation studies such as organoleptic evaluation, thickness, folding endurance, weight uniformity, flatness, pH determination, percentage moisture loss, drug content and permeation studies. FTIR revealed no interaction between drug and polymers. X-ray diffractometry (XRD) studies showed was that both drugs were of crystalline nature which was further confirmed by SEM. Surface (SEM) showed smooth surface of the patches. The...

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