Hypoglycemic and Hypolipidaemic Effect of Allium Cepa in Streptozotocin-Induced Diabetes (original) (raw)

Abstract

Type 2 diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. It is generally characterized by hyperglycaemia and hyperlipidaemia culminating in severe morbidities. Epidemiologic studies and randomized clinical trials show that type 2 diabetes is largely preventable through diet and lifestyle modifications without major recourse to pharmacological measures. This study aimed to assess the antidiabetic and antilipidaemic activities of Allium cepa (onions) in streptozotocin-induced diabetic male Wistar rats. Adult male Wistar rats were randomly divided into eight (8) groups of five rats each (n=5). Groups 1a and 2a served as the control groups. Diabetes was induced in the rats by an intraperitoneal injection of streptozotocin (60mg/kg). The normoglycaemic groups (1b, 1c and 1d) and the streptozotocin-induced diabetic groups (2b, 2c and 2d) were treated with graded doses of A. cepa extract (ACE) (0.4g/100gbw, and 0.6g/10...

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