Antihyperglycemic and hypolipidemic effects of Hibiscus schizopetalus (Mast) Hook in alloxan-induced diabetic rats (original) (raw)
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Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats
GSC Biological and Pharmaceutical Sciences
Plants are known to possess relatively high efficacy in the treatment of several chronic diseases with fewer adverse effects. In the recent years, numerous medicinal plants have been reported to be effective in treating diabetes. Hence, the present study aims to evaluate the antidiabetic property of hydroalcoholic extract of Hibiscus sabdariffa (HS) calyces in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg, b.w), in male Wistar rats. Diabetic rats were administered daily oral doses of HS (100, 200 and 400 mg/kg body weight) and Glibenclamide (10 mg/kg) for 21 days. Then, blood glucose levels, oral glucose tolerance test and lipid profiles were determined. Treatment with HS resulted in a significant dose dependent reduction of blood glucose levels accompanied by a significant improvement in body weight. The extract also enhanced the glucose tolerance and significantly decreased cholesterol, triglycerides, and low-density lipoproteins lev...
GSC Biological and Pharmaceutical Sciences
This study investigates the phytochemicals, antidiabetic and hypolipidemic activities of Hibiscus sabdariffa methanol leaves extract in alloxan induced diabetic wistar rat by administering graded oral doses (100, 200 and 400 mg/kg body weight) for 21 days. Results revealed that the methanol leaf extract of Hibiscus sabdariffa contains 51.90±3.89 mg/100g of tannins, 102.56±6.89 mg/100g of saponins, 54.78±3.89 mg/100g of alkaloids, 67.45±3.87 mg/100g of flavonoids and 121.54±5.67 mg/100g of phenols. The extract showed dosed dependent significant (p<0.05) antidiabetic activity with significant improvement in body weight. The extract also resulted in significant (p<0.05) reduction serum cholesterol, triglycerides. LDL-cholesterol level and increase HDL-cholesterol when compared with untreated control. In conclusion, this study demonstrates, for the first time, that Hibiscus sabdariffa is effective in inhibiting hyperglycemia and dyslipidemia in diabetes condition.
International journal of biomedical research, 2016
Aim and Objective: The present study was designed to assess antidiabetic, hypolipidimic, antioxidant and histopathological effects of hydroalcoholic extract of Hibiscus rosa-sinensis (EHBS) root on alloxan-induced diabetes in rats. Materials and Methods: Study was conducted on six groups with six wistar rats in each group for the period of 4 weeks. Group I: served as normal control (NC), rats administered with gum acacia 1 ml daily, group II: consider as diabetic control (DC) treated with alloxon 150 mg/kg body wt. Whereas Hibiscus rosa-sinensis roots extract was given orally in group III (DE1), group IV (DE2), group V (DE3) at doses of 50, 100 and 200 mg/kg body weight dissolved in distilled water respectively. Group VI (DG) was given glibenclamide (5 mg/kg) as a standard drug and results were compared in reference to it.Results: Administration of root extract for 28 days resulted in significant decreased in the levels of blood glucose, plasma lipids but increases in HDL levels, al...
— Diabetes mellitus is one of the common metabolic disorders across the globe. Many lipoprotein abnormalities are seen in the untreated, hyperglycemic diabetic patients. This disease affects around 2.8% of the world's population and is likely to cross 5.4% by the year 2025. The use of herbal medicines for curing various ailments have been known since time in memorial and the herbal extracts have become a growing part of modern medicine. H. rosa sinensis has been used for the treatment of a variety of diseases. It is an easily available plant for natural remedies. The present study was undertaken to investigate the antidiabetic effects of the ethanolic Hibiscus flower extract in diabetes induced Wister rats which have been made hyperlipidaemic by feeding them with high fat diet. The serum blood glucose levels and lipid profile was found to be significantly increased in the hyperlipidaemic diabetic rat models while the level of plasma insulin was lowered. Treated groups administered with Hibiscus flower extract showed changes in the above biochemical parameters and it was found that among the three doses, 500 mg/kg showed the best result when compared to the other two doses. HRSFE exhibited potential antidiabetic against HFD fed alloxan induced diabetic Wister rats.
Diabetes is chronic diseases spread worldwide in all type of age group. This research work show anti-diabetic activity of Hibiscus mutabilis in the form of methanolic extract. The methanolic extract of leaf of Hibiscus mutabilis (Malvaceae) were tested for anti-diabetic activity in alloxan induced diabetes wistar rats and compared with standard. Methanolic extract has shown significant protection and maximum reduction in glucose. The maximum reduction in glucose was observed after 6 hours at a dose level of 200 mg/kg of body weight. Blood sugar level was determined using digital glucometer. The results of this comprehensive study reveal that Hibiscus mutabilis leaf shown statistically significant anti-diabetic activity in comparison to the standard glibenclamide.
Effect of Red Hibiscus Aqueous Extract on Alloxan-Induced Diabetes in Adult Male Albino Rats
Al-Azhar Medical Journal, 2015
Background: Diabetes mellitus is a growing metabolic disorder at a fast rate throughout the world, and it is the 16 th leading cause of global mortality. The significant anti-dyslipidemic effect of red Hibiscus extract may be safe and better alternative available over other agents in diabetic-associated dyslipidemia. Objective: Demonstrating the antioxidant property of Hibiscus in the role of reduction of blood glucose level. Material and Methods: Sixty adult male albino rats were used in this study. The rats were divided into six equal groups, i.e. control, alloxan-treated, hot red Hibiscus extract-treated cold red Hibiscus extract-treated, alloxan-treated plus hot red Hibiscus extract-treated and alloxan-treated plus cold red Hibiscus extracttreated groups. Blood samples were obtained for determination of serum glucose, insulin, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol as well as histopathological changes of the pancreas. Results: Treatment with red Hibiscus (hot and cold) extract was found to be effective in ameliorating lipid profile, blood glucose and insulin levels. Conclusion: The hypoglycemic, hypolipidemic and antioxidant properties of red Hibiscus were valuable in treatment of diabetes mellitus, and great consideration should be taken toward the use of Hibiscus as a complementary therapy beside ordinary anti-diabetic and hypolipidemic drugs.
Aim and Objective: Aim of the present research was to evaluate various biological activities of Hibiscus Rosa Sinensis flower extract in alloxan induced diabetes in rabbits. Materials and Methods: Albino rabbits of either sex weighing between 1.5 to 2.5 kg were chosen for the study and divided into 6 groups of 6 animals each. The hydroalcoholic extract of Hibiscus Rosa Sinensis flowers (HEFHR) was used as test extract. Glibenclamide was administered as drug for comparison. Diabetes was induced by alloxan (150 mg/kg body weight). Group I served as normal control and group II as diabetic control. Group III, IV, V received HEFHR in the doses of 50, 100, 200 mg/kg orally respectively whereas group VI received glibenclamide 5mg/kg body weight for a period of 72 hrs. Results: HEFHR was found to be more effective in antidiabetic activity than glibenclamide, as flower extract produced a gradual fall in blood sugar level in 72 hour whereas glibenclamide has shown sudden fall in blood sugar level within 24 hours which remains constant up to 72 hour. The oral administration of flower extract has significantly improved dyslipidemia by reducing raised level of lipids and it was more efficacious in lipid lowering effect, when compared to glibenclamide. Flower extract of hibiscus was more effective in antioxidative activity than glibenclamide. Conclusion: Significant anitidiabetic effect of flower extract in rabbits may be due to antioxidant properties and significant antidyslipidemic effect protects the cardiac complications especially ischemic heart disease. Hence, it may be a safe and better alternative available over the antidiabetic agents.
Impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats
Journal of Nephropharmacology, 2016
Introduction: Hibiscus esculentus is capable to produce various molecules including phenolic and flavonoid compounds, phytosteroids with antioxidant property. Therefore, it has the potential to show antidiabetic activities. Objectives: This study was aimed to evaluate the impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats. The flavonoid, flavonol and phenolic components, as well as antioxidant activity of Hibiscus esculentus was also evaluated. Materials and Methods: In a preclinical study, 40 male Wistar rats were designated into four 10-member groups, i.e., control, diabetic control, diabetic Hibiscus esculentus, and diabetic glibenclamide. The Alloxan-induced diabetic rats received extracts orally for four weeks. Then, the serum biochemical factors were measured and compared by analysis of variance (ANOVA). Results: Serum glucose, triglyceride (TG), cholesterol, and low density lipoprotein cholesterol (LDL-C) were significantly decreased and high...
Bangladesh Pharmaceutical Journal, 2013
Diabetes associated dyslipidemia is one of the major causes of disability in western as well as in developing countries. The present study was designed to investigate the effect of ethanolic extract of Hibiscus rosa sinensis (EHBS) leaves on alloxan-induced diabetes with dyslipidemia in rats. Treatment of alloxan-induced diabetes with most effective observed dose (2.0 mg/kg body weight) of EHBS for 1 week significantly reduced glucose level, TC, TG and LDL-C, with the increase of HDL-C and weight of kidney, pancreas and liver when compared with diabetic rats. The observation was also made for consecutive 4 weeks to confirm the results obtained in one week model. Like one week, we got similar results when the treatment of alloxan-induced rats was done with the EHBS for 4 weeks. The results indicated that the EHBS leaves, in comparison with metformin, had profound hypoglycemic and hypolipidemic activities.
Global Journal of Pure and Applied Sciences
Background: Diabetes is a disease condition of metabolism clinically expressed by chronic hyperglycemia and protein disorder; it has a link to several complications that cause morbidity and mortality and native plants with antidiabetic properties can be used to avoid further progression of the disease Objective: To investigate the antidiabetic properties of combined extract of hibiscus sabdariffa l., zingiber officinale roscoe and piper nigrum l. as well as its effect on selected hematological parameters in alloxan induced diabetic wistar rats Methods: Thirty (30) male wistar rats aged between 8-10 weeks, weighing 130g to 138g were divided into five groups of six rats each and acclimatized for a week prior to the commencement of the treatments. Of the 5 groups, 4 were induced with 170mg/kg body weight of alloxan. Diabetic rats were treated with 250mg/kg and 500mg/kg of the combined extract as well as 500mg/kg of metformin. The last diabetic group was left untreated and served as the...