Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome (original) (raw)
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Vitamin D and polycystic ovary syndrome: an integrating review
International Archives of Medicine, 2017
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathyin women of reproductive age. It causes a metabolic syndrome characterized by insulin resistance, hyperinsulinemia, and dyslipidemia. Vitamin D deficiency and its association with PCOS still represents a controversial subject in the literature. Objective: In this context, this study aimed to understand the association between polycystic ovary syndrome and vitamin D deficiency, and how it occurs. Method: It was an integrative review conducted in the PubMed, Scopus, LILACS, and CINAHL databases from August 2016 to January 2017, with a sample of 7 articles analyzed in their entirety. Results: The evidences according to the studies conducted and the conclusions they identified. Conclusions: It was concluded that we cannot yet assume that vitamin D deficiency contributes to the pathogenesis of PCOS, nor that the syndrome causes vitamin D deficiency, since the studies are controversial and there is a need for...
Nutrients
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8ā13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecologica...
Role of Vitamin D in the Etiology of Polycystic Ovary Syndrome, A Review
2018
Polycystic ovary syndrome (PCOS) is a common cause of ovarian dysfunction in women suffering from anovulation. It is characterized by chronic anovulation, hyperandrogenism, and/or the presence of polycystic ovaries on ultrasonography. No single etiologic factor fully accounts for the spectrum of abnormalities in PCOS. Interactions between genetic and environmental factors such as genetic, gonadotropins and insulin contribute to the pathogenesis of PCOS. Vitamin D deficiency among PCOS women is prevalent and reaches 67 to 85 percent. The prevalence of vitamin D deficiency has been found to be associated with metabolic syndrome which may have great impact on public health. Low 25(OH)D levels may exacerbate the symptoms of PCOS, including insulin resistance, ovulatory, menstrual irregularities, infertility, hyperandrogenism, obesity and elevate the risk of cardiovascular diseases. Many observational studies suggest a possible role of vitamin D in an inverse association between vitamin ...
2018
Vitamin D deficiency and overweight are common in women suffering from polycystic ovary syndrome (PCOS). Weight gain in PCOS is an important factor for the development of menstrual dysfunction and signs of hyperandrogenism and alopecia. Features of PCOS such as oligomenorrhea can be predicted by anthropometric measurements as body mass index (BMI). Therefore, the aim of this trial was to study the effect of 50,000 IU/week of vitamin Dā supplementation on the body composition and on the anthropometric measurements of overweight women with PCOS and to examine the impact of this effect on ovaries ultrasonography and menstrual cycle regularity. The study design was a prospective randomized, double-blinded placebo-controlled clinical trial conducted on 60 overweight Jordanian women aged (18-49) years with PCOS and vitamin D deficiency. The study participants were divided into two groups; vitamin D group (n = 30) who were assigned to receive 50,000 IU/week of vitamin Dā and placebo group ...
Middle East Fertility Society Journal, 2018
Introduction: Metabolic disturbances are common in women with PCOS. Some studies have suggested that vitamin D deficiency may play a role in metabolic disorders and insulin resistance, although limited clinical trials on this subject have been published with contradictory findings. Therefore, the aim of this study was to investigate the effects of vitamin D on metabolic disorders in women with PCOS and vitamin D deficiency. Methods: This study was a randomized-blinded clinical trial. Eighty-six women diagnosed with PCOS and vitamin D deficiency aged between 18 and 45 were enrolled. They were randomly divided into two groups of interventional (44 women) and control (42 women). In each group, patient assignment was done using randomized blocks of four. Based on the block combination, vitamin D at a dose of 50,000 unit per week (Interventional group) and a dose of 50,000 units per month (Control group) and elemental calcium at a dose of 1000 mg per day were administered by a nurse. Metabolic parameters (i.e., LDL, HDL, total cholesterol, HOMA-IR, serum insulin, FBS, TG) and serum vitamin D were measured at baseline and 2 months after treatment. Results: In vitamin D group, serum levels of 25 (OH) D increased. There was no significant difference in the metabolic parameters before and after treatment in each group (P > .05). At the end of the study, the metabolic parameters and HOMA-IR did not show a significant difference. Conclusion: This study showed that vitamin D replacement in women with PCOS and vitamin D deficiency has no effect on the improvement of metabolic parameters and HOMA-IR.
The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review
European Journal of Endocrinology, 2013
ContextMetabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS.ObjectiveThe aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS.Design and methodsA systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature.ResultsWe found 29 eligible trials with inconsistency in ...
Hormone and Metabolic Research
This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. The inclusion criteria were women 18ā45 years of age with polycystic ovary syndrome and comparing the metabolic or endocrine parameters between placebo and vitamin D supplementation groups. A total of ten studies were selected for this review. We found that vitamin D supplementation had a significant effect on insulin metabolism, total serum testosterone, hirsutism, C-reactive protein, and total antioxi...
Vitamin D in the aetiology and management of polycystic ovary syndrome
Clinical Endocrinology, 2012
Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS), with the 67-85% of women with PCOS having serum concentrations of 25-hydroxy vitamin D (25OHD) <20 ng/ml. Vitamin D deficiency may exacerbate symptoms of PCOS, with observational studies showing lower 25OHD levels were associated with insulin resistance, ovulatory and menstrual irregularities, lower pregnancy success, hirsutism, hyperandrogenism, obesity and elevated cardiovascular disease risk factors. There is some, but limited, evidence for beneficial effects of vitamin D supplementation on menstrual dysfunction and insulin resistance in women with PCOS. Vitamin D deficiency may play a role in exacerbating PCOS, and there may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomized controlled trials are required to confirm the potential benefits of vitamin D supplementation in this population.
PCOS (polycystic ovarian syndrome), the most frequent hormonal condition in reproductiveage women, is the most common. Having polycystic ovaries, anovulation, and clinical and/or biochemical signs of high testosterone describe the disease. Few foods naturally contain fatsoluble vitamin D3. A supplement may help if required. Its extensive impacts are due to its steroid hormone status. High or low vitamin D3 levels in women with polycystic ovaries and those who have trouble becoming pregnant are the focus of this investigation. Our study found that vitamin D3 levels in infertile women drop significantly compared to healthy controls, stratified by age. Compared to healthy persons in particular age groups, polycystic ovarian syndrome females had a statistically significant increase in vitamin D3 levels. Vitamin D3 levels are similar in PCOS and infertile women. Our study found that vitamin D3 levels in women who cannot conceive and those with polycystic ovary syndrome (PCOS), whether high or low, may regulate ovulation and improve fertility.
Metabolism, 2011
Both vitamin D deficiency and polycystic ovary syndrome (PCOS) are associated with aspects of metabolic syndrome, but it is unclear whether vitamin D deficiency contributes to the metabolic disturbances commonly found in women with PCOS. This study sought to investigate (1) the prevalence of vitamin D deficiency in PCOS women in Scotland and (2) the relationship between vitamin D status and metabolic risk factors. This was an observational study on 52 women (25 in PCOS group and 27 in control group). Serum 25-hydroxyvitamin D concentrations less than 25 nmol/L were classified as severe vitamin D deficiency and were found in 44.0% and 11.2% of subjects in the PCOS and control groups, respectively (P = .047).