No association between the ALDH2 promoter polymorphism rs886205, alcohol dependence, and risky alcohol consumption in a German population (original) (raw)

Susceptibility to the negative effects of alcohol is linked to the ALDH2 enzyme, with rs671 polymorphism providing protection primarily in East-Asian populations. This study evaluates the impact of the noncoding polymorphism rs886205 in a German cohort comprising 352 alcohol-dependent patients and over 6000 controls. Results found no significant associations between rs886205 genotype or allele frequencies and alcohol dependence or risky consumption, suggesting that this polymorphism does not influence alcohol-related risk in this population.