Participation of ER and ER in glucose homeostasis in skeletal muscle and white adipose tissue (original) (raw)

Barros RP, Gabbi C, Morani A, Warner M, Gustafsson JA. Participation of ER and ER in glucose homeostasis in skeletal muscle and white adipose tissue. Am J Physiol Endocrinol Metab 297: E124–E133, 2009. First published April 14, 2009; doi:10.1152/ajpendo.00189.2009.—Glucose uptake and homeostasis are regulated mainly by skeletal muscle (SM), white adipose tissue (WAT), pancreas, and the liver. Participation of estradiol in this regulation is still under intense investigation. We have demonstrated that, in SM of male mice, expression of the insulinregulated glucose transporter (GLUT)4 is reduced by estrogen receptor (ER) agonists. In the present study, to investigate the relative contributions of ER and ER in glucose homeostasis, we examined the effects of tamoxifen (Tam) on GLUT4 expression in SM and WAT in wild-type (WT) and ER / mice. ER / mice were characterized by fasting hypoglycemia, increased levels of SM GLUT4, pancreatic islet hypertrophy, and a belated rise in plasma insuli...