Hydrogel as drug delivery system (original) (raw)

As A Review on Hydrogels as Drug Delivery in the Pharmaceutical Field

Hydrogel is a network of polymer chains that are water-insoluble, sometimes found as a colloidal gel in which water is the dispersion medium. Hydrogels are crosslinked polymer networks that absorb substantial amounts of aqueous solutions. Due to their high water content, these gels resemble natural living tissue more than any other type of synthetic biomaterial. Several techniques have been reported for the synthesis of hydrogels like co polymerization/crosslinking of co-monomers using multifunctional co-monomer, which acts as crosslinking agent. Chemical initiator initiates the polymerization reaction. Some applications are used of hydrogels in human body. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosens...

Hydrogels for Pharmaceutical and Biomedical Applications

Critical Reviews in Therapeutic Drug Carrier Systems, 2005

Hydrogels are crosslinked hydrophilic polymer structures that can imbibe large amounts of water or biological fl uids. Hydrogels are one of the upcoming classes of polymer-based systems that embrace numerous biomedical and pharmaceutical applications. Th is review discusses various parameters of hydrogels such as surface properties, water content and swelling behavior, eff ect of nature of polymer, ionic content, and thermodynamics, all of which can infl uence the biomedical usage of hydrogels. Meanwhile, intelligent or environment-sensitive hydrogels and bioadhesive hydrogels continue to be important materials for medical applications; therefore, a part of this review is devoted to some of their important classes. Hydrogels are extensively used for various biomedical applications-tissue engineering, molecular imprinting, wound dressings materials, immunoisolation, drug delivery, etc. Th us, this review aims to throw light on immense AU: "THE NUMEROUS"? applications that hydrogels have in the biomedical arena.

Potential Applicabilities of Hydrogels - A Literature Survey

2012

Hydrogels are cross linked polymeric network, which have the ability to hold water within the space available among the polymeric chains. The hydrogels have been used extensively in various biomedical application, viz. drug delivery, cell carriers and/or entrapment, wound management and tissue engineering. Hydrogels are swellable polymeric materials, have been widely as a carrier of drug delivery systems. These biomaterials have gained attention owing to their peculiar characteristics like swelling in aqueous medium, pH and temperature sensitivity or sensitivity towards other stimuli. Hydrogels being biocompatible material have been recognized to function as drug protectors, especially of peptide and proteins, from in vivo environment. Also these swollen polymers are helpful as targetable carriers for bioactive drugs with tissue specificity and environmental sensitive hydrogels have enormous potential for various environmental variables, such as low pH and elevated temperature, are ...

Hydrogels: A Novel Drug Delivery System

Journal of Biomedical Research & Environmental Sciences

Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic polymers. They are made three-dimensional by the creation of the cross-links by joining them through covalent or ionic bonds. Hydrogels have been used in various areas including industry and medicine due to their excellent characteristics such as high swelling capacity, high content of water, compatibility with other biological molecules, controlled chemical and physical properties, high mechanical integrity and biodegradability. They have been the center of attention of researchers from the past 50 years because of their promising applications in industries and other areas. They are used in different fields, in medicine, in the diagnosis of the diseases, in culturing of cells, in injuries as wound healers, in cosmetics, in skin diseases like pruritis, in environmental pollution reduction and other miscellaneous applications such as in diapers for babies and sanitary products. Extensive...

Hydrogels Used As A Potential Drug Delivery System: A Review

International Journal of Pharmaceutical & Biological …, 2011

Hydrogels, the swellable polymeric materials have been widely investigated as the carrier for drug delivery systems. These biomaterials have gained attention owing to their peculiar characteristics like swelling in aqueous medium, pH and temperature sensitivity or sensitivity towards other stimuli. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. Also, these swollen polymers are helpful as targetable carriers for bioactive drugs with tissue specificity. Hydrogels are presently under investigation as a delivery system for bioactive molecules, because of their similar physical properties as that of living tissue, which is due to their high water content, soft and rubbery consistency, and low interfacial tension with water or biological fluids. This review presents an overview to the advances in hydrogel based drug delivery that have became the interest of most researchers.

Hydrogels: Properties and Applications in Biomedicine

Molecules

Hydrogels are crosslinked polymer chains with three-dimensional (3D) network structures, which can absorb relatively large amounts of fluid. Because of the high water content, soft structure, and porosity of hydrogels, they closely resemble living tissues. Research in recent years shows that hydrogels have been applied in various fields, such as agriculture, biomaterials, the food industry, drug delivery, tissue engineering, and regenerative medicine. Along with the underlying technology improvements of hydrogel development, hydrogels can be expected to be applied in more fields. Although not all hydrogels have good biodegradability and biocompatibility, such as synthetic hydrogels (polyvinyl alcohol, polyacrylamide, polyethylene glycol hydrogels, etc.), their biodegradability and biocompatibility can be adjusted by modification of their functional group or incorporation of natural polymers. Hence, scientists are still interested in the biomedical applications of hydrogels due to th...

Hydrogels as potential drug delivery systems

2009

Hydrogels, the swellable polymeric materials, have been widely investigated as the carrier for drug delivery systems. These biomaterials have gained attention owing to their peculiar characteristics like swelling in aqueous medium, pH and temperature sensitivity or sensitivity towards other stimuli. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in vivo environment. Also these swollen polymers are helpful as targetable carriers for bioactive drugs with tissue specificity. This article presents an overview to the advances in hydrogel based drug delivery that have become the interest of most researchers.

A Comprehensive Review on Hydrogels

International Journal of Current Pharmaceutical Research, 2016

Polymers play a vital role in pharmaceutical development. Efforts have been continuously made to search a polymer that act in a controlled& desired way. Hydrogel development has solved many such issues. Hydrogels are hydrophilic, three-dimensional networks. Which are able to imbibe large amounts of water or biological fluids & thus resembles to a large extent, a biological tissue. They are insoluble due to the presence of physical or chemical crosslinks such as entanglements& crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as PH, ionic strength, temperature. The main aim of this article is to give a concise review on introduction, preparation methods, types, & various applications of hydrogels in the pharmaceutical field. Keywords: Hydrogels, Types of hydrogels, Preparation methods, Applications.

Hydrogels for biomedical applications

Advanced Drug Delivery Reviews, 2002

This article reviews the composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices. The most important properties of hydrogels relevant to their biomedical applications are also identified, especially for use of hydrogels as drug and cell carriers, and as tissue engineering matrices.

Hydrogel based drug delivery system: A review

World Journal of Biology Pharmacy and Health Sciences

Hydrogels are the three-dimensional hydrophilic network which is crosslinked physically or chemically. Hydrogels are also called as hydrophilic gels because they absorb considerate amount of water. The characteristic properties of hydrogels are swelling, mechanical properties, biodegradable, elasticity, biocompatible, easy to modify, flexibility, etc. They are classified based on source, polymeric composition, biodegradability, configuration, cross linking, physical appearance, chemical charges, and drug release. Hydrogels can be synthesized from natural, synthetic, semisynthetic polymers via physical, chemical crosslinking, through grafting, coacervation and polymerization. The hydrogels are useful in daily life and their major applications are drug delivery to oral cavity, GI tract, rectal, ocular, protein, subcutaneous, transdermal, controlled drug delivery, preparation of contact lenses, wound healing, tissue engineering, biosensing, bacterial culture preparation, and various ot...