Peptide Nanotube Nematic Phase (original) (raw)

Abstract

The self-assembly of the trifluoroacetate salt of the short peptide (ala) 6 -lys (A 6 K) in water has been investigated by cryo-transmission electron microscopy and small-angle X-ray scattering. For concentrations below ca. 12%, the peptide does not self-assemble but forms a molecularly dispersed solution. Above this critical concentration, however, A 6 K self-assembles into several-micrometer-long hollow nanotubes with a monodisperse crosssectional radius of 26 nm. Because the peptides carry a positive charge, the nanotubes are charge-stabilized. Because of the very large aspect ratio, the tubes form an ordered phase that presumably is nematic. (16) Knaapila, M.; Svensson, C.; Barauskas, J.; Zackrisson, M.; Nielsen, S. S.; Toft, K. N.; Vestergaard, B.; Arleth, L.; Olsson, U.; Pedersen, J. S.; Cerenius, Y.

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (19)

  1. Merrifield, R. B. J. Am. Chem. Soc. 1963, 85, 2149-2154.
  2. Howl, J. Peptide Synthesis and Applications; Humana Press: Totawa, NJ, 2005.
  3. Gazit, E. Chem. Soc. Rev. 2007, 36, 1263-1269.
  4. Ulijn, R. V.; Smith, A. M. Chem. Soc. Rev. 2008, 37, 664-675.
  5. Zhao, X. A.; Zhang, S. G. Macromol. Biosci. 2007, 7, 13-22.
  6. Pouget, E.; Dujardin, E.; Cavalier, A.; Moreac, A.; Valery, C.; Marchi- Artzner, V.; Weiss, T.; Renault, A.; Paternostre, M.; Artzner, F. Nat. Mater. 2007, 6, 434-439.
  7. Reches, M.; Gazit, E. Science 2003, 300, 625-627.
  8. Harper, J. D. BMC Chem. Biol. 1997, 4, 119-125.
  9. Walsh, D. M.; Lomakin, A.; Benedek, G. B.; Condron, M. M.; Teplow, D. B. J. Biol. Chem. 1997, 272, 22364-22372.
  10. Dong, H.; Paramonov, S. E.; Aulisa, L.; Bakota, E. L.; Hartgerink, J. D. J. Am. Chem. Soc. 2007, 129, 12468-12472.
  11. Soto, P.; Griffin, M. A.; Shea, J. E. Biophys. J. 2007, 93, 3015-3025.
  12. Zhang, S. G.; Holmes, T.; Lockshin, C.; Rich, A. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 3334-3338.
  13. Valery, C.; Paternostre, M.; Robert, B.; Gulik-Krzywicki, T.; Nar- ayanan, T.; Dedieu, J. C.; Keller, G.; Torres, M. L.; Cherif-Cheikh, R.; Calvo, P.; Artzner, F. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 10258-10262.
  14. Krysmann, M. J.; Castelletto, V.; McKendrick, J. E.; Clifton, L. A.; Hamley, I. W.; Harris, P. J. F.; King, S. M. Langmuir 2008, 24, 8158.
  15. Aggeli, A.; Nyrkova, I. A.; Bell, M.; Harding, R.; Carrick, L.; McLeish, T. C. B.; Semenov, A. N.; Boden, N. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 11857-11862.
  16. Hamley, I. W.; Krysmann, M. J.; Castelletto, V.; Noirez, L. Adv. Mater. 2008, 20, 4394-4397.
  17. Onsager, L. Ann. N.Y. Acad. Sci. 1949, 51, 627.
  18. Stroobants, A.; Lekkerkerker, H. N. W.; Odijk, T. Macromolecules 1986, 19, 2232-2238.
  19. Vauthey, S.; Santoso, S.; Gong, H. Y.; Watson, N.; Zhang, S. G. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 5355-5360.