Mesenchymal Stem Cell's in Therapy- a Review (original) (raw)

Stem cells are relatively unique and charecteristic in comparision with the rest of mammalian cells especially in terms of lacking tissue speceficity and undifferentiated phenotype unless exposed to specefic selective signals. Mesenchymal stem cells are multipotent stromal cells derived from the mesoderm of embryonic connective tissue. Mesenchymal stem cells which are found and isolated from bone marrow, adipose tissue, umbilical cord blood are the precursors of any tissues of mesenchymal lineage including bone, tendon, cartilage, fat and muscle. Though many aspects of these cells such as commitment, differentiation, transdifferentiation and plasticity of cell population are not yet decoded and are yet to be brought into limelight, a broad spectrum of therepeutic potential and clinical applications seems to be transparent. Currently mesenchymal stem cell therapy is being assessed and analysed for numerous disease targets which are presently under pre-clinical and clinical trials. Th...