Análisis epidemiológico y molecular de la virulencia y la antibiorresistencia en acinetobacter baumannii (original) (raw)

2016

Abstract

Acinetobacter baumannii is a pathogen implicated in infecting critically ill patients. CRAB isolates are increasing in frequency worldwide, forcing clinicians to use colistin. A. baumannii has numerous intrinsic resistance mechanisms, virulence determinants, and can acquire resistance to almost all antibiotics. OXAs among clinically significant ICs are the most common cause of carbapenem resistance. A. baumannii can differentially express virulence determinants and the cause of this is not extensively investigated. In this Doctoral Thesis, the relationship between clonality, virulence, and antimicrobial resistance is investigated in two sets of isolates obtained from hospitals from Spain and Lebanon. Our aim is providing clinicians and infection control specialists with tools that could be used to improve therapy and limit the spread of CRAB isolates; and to better understand the interaction between virulence and antibiotic resistance. Fifty nine clinical A. baumannii isolates were ...

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